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Molecularly defined sinonasal malignancies: an overview with focus on the current WHO classification and recently described provisional entities
A. Skálová, A. Agaimy, M. Bradova, VV. Poorten, E. Hanna, O. Guntinas-Lichius, A. Franchi, H. Hellquist, RHW. Simpson, F. Lopéz, S. Nuyts, C. Chiesa-Estomba, SP. Ng, A. Homma, Y. Teng, I. Leivo, A. Ferlito
Jazyk angličtina Země Německo
Typ dokumentu časopisecké články, přehledy
NLK
ProQuest Central
od 2003-01-01 do Před 1 rokem
Medline Complete (EBSCOhost)
od 2011-01-01 do Před 1 rokem
Nursing & Allied Health Database (ProQuest)
od 2003-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2003-01-01 do Před 1 rokem
- MeSH
- lidé MeSH
- nádorové biomarkery * genetika analýza MeSH
- nádory vedlejších dutin nosních * patologie genetika klasifikace diagnóza MeSH
- Světová zdravotnická organizace MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Classification of tumors of the head and neck has evolved in recent decades including a widespread application of molecular testing in tumors of the sinonasal tract, salivary glands, and soft tissues with a predilection for the head and neck. The availability of new molecular techniques has allowed for the definition of multiple novel tumor types unique to head and neck sites. Moreover, an expanding spectrum of immunohistochemical markers specific to genetic alterations facilitates rapid identification of diagnostic molecular abnormalities. As such, it is currently possible for head and neck pathologists to benefit from a molecularly defined tumor classification while making diagnoses that are still based largely on histopathology and immunohistochemistry. This review covers the principal molecular alterations in sinonasal malignancies, such as alterations in DEK, AFF2, NUTM1, IDH1-2, and SWI/SNF genes in particular, that are important from a practical standpoint for diagnosis, prognosis, and prediction of response to treatment.
Bioptic Laboratory Ltd Pilsen Czech Republic
Coordinator of the International Head and Neck Scientific Group Padua Italy
Department of Anatomical Pathology University of Calgary Calgary AB Canada
Department of Head and Neck Surgery The University of Texas MD Anderson Cancer Center Houston TX USA
Department of Otorhinolaryngology Jena University Hospital Jena Germany
Department of Pathology Turku University Hospital Turku Finland
Department of Translational Research School of Medicine University of Pisa Pisa Italy
Faculty of Medicine and Biomedical Sciences University of Algarve Faro Portugal
Institute of Biomedicine Pathology University of Turku Turku Finland
Citace poskytuje Crossref.org
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