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Helicobacter pylori infection found during upper endoscopy performed for the diagnosis of celiac, inflammatory bowel diseases, and eosinophilic esophagitis: A multicenter pediatric European study
K. Kotilea, C. Romano, E. Miele, A. Kindermann, Y. Dolstra, Z. Misak, V. Urbonas, J. Sykora, P. Urruzuno, A. Krauthammer, M. Rogalidou, K. Dimakou, T. Zangen, E. Roma, A. Zellos, ML. Cilleruelo, M. M'Rini, P. Bontems, Y. Sahin, M. Tavares, T....
Language English Country England, Great Britain
Document type Journal Article, Multicenter Study
PubMed
38790089
DOI
10.1111/hel.13092
Knihovny.cz E-resources
- MeSH
- Celiac Disease * diagnosis epidemiology MeSH
- Child MeSH
- Eosinophilic Esophagitis * epidemiology diagnosis MeSH
- Endoscopy, Gastrointestinal MeSH
- Helicobacter pylori * isolation & purification MeSH
- Inflammatory Bowel Diseases * epidemiology diagnosis microbiology MeSH
- Helicobacter Infections * diagnosis epidemiology drug therapy MeSH
- Humans MeSH
- Adolescent MeSH
- Child, Preschool MeSH
- Prevalence MeSH
- Retrospective Studies MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Adolescent MeSH
- Male MeSH
- Child, Preschool MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Multicenter Study MeSH
- Geographicals
- Europe MeSH
BACKGROUND: Helicobacter pylori may be found during upper gastrointestinal endoscopy (UGE) performed to diagnose celiac disease (CeD), inflammatory bowel disease (IBD), and eosinophilic esophagitis (EoE). We aimed to describe the frequency of H. pylori in children undergoing UGE for CeD, IBD, and EoE and the number of children receiving eradication treatment. MATERIALS AND METHODS: A retrospective multicenter study from 14 countries included pediatric patients diagnosed with CeD, IBD, and EoE between January 2019 and December 2021. DATA COLLECTED: age, gender, hematologic parameters, endoscopic, histologic, and H. pylori culture results, and information on eradication treatment. RESULTS: H. pylori was identified in 349/3890 (9%) children [167 (48%) male, median 12 years (interquartile range 8.1-14.6)]. H. pylori was present in 10% (173/1733) CeD, 8.5% (110/1292) IBD and 7.6% (66/865) EoE patients (p = NS). The prevalence differed significantly between Europe (Eastern 5.2% (28/536), Southern 3.8% (78/2032), Western 5.6% (28/513)) and the Middle East 26.6% (215/809) [odds ratio (OR) 7.96 95% confidence interval (CI) (6.31-10.1) p < 0.0001]. Eradication treatment was prescribed in 131/349 (37.5%) patients, 34.6% CeD, 35.8% IBD, and 56.1% EoE. Predictors for recommending treatment included erosions/ulcers [OR 6.45 95% CI 3.62-11.47, p < 0.0001] and nodular gastritis [OR 2.25 95% CI 1.33-3.81, p 0.003]. Treatment rates were higher in centers with a low H. pylori prevalence (<20%) [OR 3.36 95% CI 1.47-7.66 p 0.004]. CONCLUSIONS: Identifying H. pylori incidentally during UGE performed for the most common gastrointestinal diseases varies significantly among regions but not among diseases. The indications for recommending treatment are not well defined, and less than 40% of children received treatment.
Arabkir Institute of Child and Adolescent Health Yerevan Armenia
Clinic of Children's Diseases of Vilnius University Faculty of Medicine Vilnius Lithuania
Division of Paediatric Gastroenterology and Hepatology Mitera Children's Hospital Athens Greece
Faculty of Medical sciences Department of Pediatrics University of Kragujevac Kragujevac Serbia
Faculty of Medicine Hebrew University of Jerusalem Jerusalem Israel
Faculty of Medicine in Pilsen Charles University Prague Prague Czech Republic
Faculty of Medicine Tel Aviv University Tel Aviv Israel
Paediatric Division Kaplan Medical Centre Rehovot Israel
Paediatric Gastroenterology Kaplan Medical Centre Rehovot Israel
Paediatric Gastroenterology Unit Hospital 12 de Octubre Madrid Spain
Pediatric Gastroenterology Division Wolfson Medical Center Holon Israel
Pediatric Gastroenterology Unit Puerta de Hierro Majadahonda Hospital Madrid Spain
References provided by Crossref.org
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