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Sleep Disorders and Cognitive Aging Among Cognitively Impaired Versus Unimpaired Older Adults

S. Lee, ME. Nelson, F. Hamada, ML. Wallace, R. Andel, OM. Buxton, DM. Almeida, C. Lyketsos, BJ. Small

. 2024 ; 64 (5) : . [pub] 20240501

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, Research Support, U.S. Gov't, Non-P.H.S., Research Support, N.I.H., Extramural, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc24014208

Grantová podpora
P30 AG066507 NIA NIH HHS - United States
RF1 AG056331 NIA NIH HHS - United States
R44 AG056250 NIA NIH HHS - United States
P30 AG062429 NIA NIH HHS - United States
R56AG065251 NIH HHS - United States
P30 AG072959 NIA NIH HHS - United States
U24 AG072122 NIA NIH HHS - United States
F31 AG077865 NIA NIH HHS - United States
R56 AG065251 NIA NIH HHS - United States
R01 HL163226 NHLBI NIH HHS - United States
R43 AG056250 NIA NIH HHS - United States
P30 AG066468 NIA NIH HHS - United States
P30 AG062421 NIA NIH HHS - United States
P30 AG066509 NIA NIH HHS - United States
P30 AG066514 NIA NIH HHS - United States
P30 AG066530 NIA NIH HHS - United States
P30 AG066444 NIA NIH HHS - United States
P30 AG066518 NIA NIH HHS - United States
P30 AG066512 NIA NIH HHS - United States
P30 AG066462 NIA NIH HHS - United States
P30 AG072979 NIA NIH HHS - United States
P30 AG072972 NIA NIH HHS - United States
P30 AG072976 NIA NIH HHS - United States
P30 AG072975 NIA NIH HHS - United States
P30 AG072978 NIA NIH HHS - United States
P30 AG072977 NIA NIH HHS - United States
P30 AG066519 NIA NIH HHS - United States
P30 AG062677 NIA NIH HHS - United States
P30 AG072980 NIA NIH HHS - United States
P30 AG062422 NIA NIH HHS - United States
P30 AG066511 NIA NIH HHS - United States
P30 AG072946 NIA NIH HHS - United States
P30 AG062715 NIA NIH HHS - United States
P30 AG072973 NIA NIH HHS - United States
P30 AG066506 NIA NIH HHS - United States
P30 AG066508 NIA NIH HHS - United States
P30 AG066508 NIA NIH HHS - United States
P30 AG066515 NIA NIH HHS - United States
P30 AG072947 NIA NIH HHS - United States
P30 AG072931 NIA NIH HHS - United States
P30 AG066546 NIA NIH HHS - United States
P20 AG068024 NIA NIH HHS - United States
P20 AG068053 NIA NIH HHS - United States
P20 AG068077 NIA NIH HHS - United States
P20 AG068082 NIA NIH HHS - United States
P30 AG072958 NIA NIH HHS - United States
P30 AG072959 NIA NIH HHS - United States

BACKGROUND AND OBJECTIVES: Sleep disorders often predict or co-occur with cognitive decline. Yet, little is known about how the relationship unfolds among older adults at risk for cognitive decline. To examine the associations of sleep disorders with cognitive decline in older adults with unimpaired cognition or impaired cognition (mild cognitive impairment and dementia). RESEARCH DESIGN AND METHODS: A total of 5,822 participants (Mage = 70) of the National Alzheimer's Coordinating Center database with unimpaired or impaired cognition were followed for 3 subsequent waves. Four types of clinician-diagnosed sleep disorders were reported: sleep apnea, hyposomnia/insomnia, REM sleep behavior disorder, or "other." Cognition over time was measured by the Montreal Cognitive Assessment (MoCA) or an estimate of general cognitive ability (GCA) derived from scores based on 12 neuropsychological tests. Growth curve models were estimated adjusting for covariates. RESULTS: In participants with impaired cognition, baseline sleep apnea was related to better baseline MoCA performance (b = 0.65, 95% confidence interval [95% CI] = [0.07, 1.23]) and less decline in GCA over time (b = 0.06, 95% CI = [0.001, 0.12]). Baseline insomnia was related to better baseline MoCA (b = 1.54, 95% CI = [0.88, 2.21]) and less decline in MoCA over time (b = 0.56, 95% CI = [0.20, 0.92]). Furthermore, having more sleep disorders (across the 4 types) at baseline predicted better baseline MoCA and GCA, and less decline in MoCA and GCA over time. These results were only found in those with impaired cognition and generally consistent when using self-reported symptoms of sleep apnea or insomnia. DISCUSSION AND IMPLICATIONS: Participants with sleep disorder diagnoses may have better access to healthcare, which may help maintain cognition through improved sleep.

Citace poskytuje Crossref.org

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$a BACKGROUND AND OBJECTIVES: Sleep disorders often predict or co-occur with cognitive decline. Yet, little is known about how the relationship unfolds among older adults at risk for cognitive decline. To examine the associations of sleep disorders with cognitive decline in older adults with unimpaired cognition or impaired cognition (mild cognitive impairment and dementia). RESEARCH DESIGN AND METHODS: A total of 5,822 participants (Mage = 70) of the National Alzheimer's Coordinating Center database with unimpaired or impaired cognition were followed for 3 subsequent waves. Four types of clinician-diagnosed sleep disorders were reported: sleep apnea, hyposomnia/insomnia, REM sleep behavior disorder, or "other." Cognition over time was measured by the Montreal Cognitive Assessment (MoCA) or an estimate of general cognitive ability (GCA) derived from scores based on 12 neuropsychological tests. Growth curve models were estimated adjusting for covariates. RESULTS: In participants with impaired cognition, baseline sleep apnea was related to better baseline MoCA performance (b = 0.65, 95% confidence interval [95% CI] = [0.07, 1.23]) and less decline in GCA over time (b = 0.06, 95% CI = [0.001, 0.12]). Baseline insomnia was related to better baseline MoCA (b = 1.54, 95% CI = [0.88, 2.21]) and less decline in MoCA over time (b = 0.56, 95% CI = [0.20, 0.92]). Furthermore, having more sleep disorders (across the 4 types) at baseline predicted better baseline MoCA and GCA, and less decline in MoCA and GCA over time. These results were only found in those with impaired cognition and generally consistent when using self-reported symptoms of sleep apnea or insomnia. DISCUSSION AND IMPLICATIONS: Participants with sleep disorder diagnoses may have better access to healthcare, which may help maintain cognition through improved sleep.
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$a Nelson, Monica E $u Department of Psychology, University of Michigan, Ann Arbor, Michigan, USA $1 https://orcid.org/0000000303955868
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