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Fine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes
Z. Chen, X. Guo, R. Tao, JR. Huyghe, PJ. Law, C. Fernandez-Rozadilla, J. Ping, G. Jia, J. Long, C. Li, Q. Shen, Y. Xie, MN. Timofeeva, M. Thomas, SL. Schmit, V. Díez-Obrero, M. Devall, F. Moratalla-Navarro, J. Fernandez-Tajes, C. Palles, K....
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem, Research Support, N.I.H., Extramural
Grantová podpora
U01 CA206110
NCI NIH HHS - United States
R01 CA263318
NCI NIH HHS - United States
001
World Health Organization - International
R37CA227130
U.S. Department of Health & Human Services | National Institutes of Health (NIH)
R01CA188214
U.S. Department of Health & Human Services | National Institutes of Health (NIH)
P30 CA008748
NCI NIH HHS - United States
U01 CA272529
NCI NIH HHS - United States
NLK
Directory of Open Access Journals
od 2015
Free Medical Journals
od 2010
Nature Open Access
od 2010-12-01
PubMed Central
od 2012
Europe PubMed Central
od 2012
ProQuest Central
od 2010-01-01
Open Access Digital Library
od 2015-01-01
Open Access Digital Library
od 2015-01-01
Medline Complete (EBSCOhost)
od 2012-11-01
Health & Medicine (ProQuest)
od 2010-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2010
Springer Nature OA/Free Journals
od 2010-12-01
- MeSH
- Asijci * genetika MeSH
- běloši * genetika MeSH
- celogenomová asociační studie * MeSH
- genetická predispozice k nemoci * MeSH
- jednonukleotidový polymorfismus * MeSH
- kolorektální nádory * genetika MeSH
- lidé MeSH
- lokus kvantitativního znaku * MeSH
- mapování chromozomů MeSH
- sekvenování exomu MeSH
- studie případů a kontrol MeSH
- transkriptom MeSH
- východní Asiaté MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
Genome-wide association studies (GWAS) have identified more than 200 common genetic variants independently associated with colorectal cancer (CRC) risk, but the causal variants and target genes are mostly unknown. We sought to fine-map all known CRC risk loci using GWAS data from 100,204 cases and 154,587 controls of East Asian and European ancestry. Our stepwise conditional analyses revealed 238 independent association signals of CRC risk, each with a set of credible causal variants (CCVs), of which 28 signals had a single CCV. Our cis-eQTL/mQTL and colocalization analyses using colorectal tissue-specific transcriptome and methylome data separately from 1299 and 321 individuals, along with functional genomic investigation, uncovered 136 putative CRC susceptibility genes, including 56 genes not previously reported. Analyses of single-cell RNA-seq data from colorectal tissues revealed 17 putative CRC susceptibility genes with distinct expression patterns in specific cell types. Analyses of whole exome sequencing data provided additional support for several target genes identified in this study as CRC susceptibility genes. Enrichment analyses of the 136 genes uncover pathways not previously linked to CRC risk. Our study substantially expanded association signals for CRC and provided additional insight into the biological mechanisms underlying CRC development.
Biomedicine Institute University of León León Spain
Broad Institute of Harvard and MIT Cambridge MA USA
Broad Institute of MIT and Harvard Cambridge MA USA
Cancer Center University of Hawaii Honolulu HI USA
Cancer Epidemiology Division Cancer Council Victoria Melbourne VIC Australia
Cancer Epidemiology Program H Lee Moffitt Cancer Center and Research Institute Tampa FL USA
Cancer Immunology Program Dana Farber Harvard Cancer Center Boston MA USA
Cancer Research Institute Seoul National University Seoul South Korea
Candiolo Cancer Institute FPO IRCCS Candiolo Italy
Case Comprehensive Cancer Center Case Western Reserve University Cleveland OH USA
Center for Gastrointestinal Biology and Disease University of North Carolina Chapel Hill NC USA
Central Finland Health Care District Jyväskylä Finland
Centre for Global Health Usher Institute University of Edinburgh Edinburgh UK
City of Hope National Medical Center Translational Genomics Research Institute Phoenix AZ USA
Clalit Health Services Personalized Genomic Service Lady Davis Carmel Medical Center Haifa Israel
Clalit National Cancer Control Center Haifa Israel
Colorectal Cancer Group ONCOBELL Program Bellvitge Biomedical Research Institute Barcelona Spain
Comprehensive Cancer Center University of Puerto Rico San Juan Puerto Rico
Consortium for Biomedical Research in Epidemiology and Public Health Madrid Spain
Department of Biomedical Informatics Vanderbilt University School of Medicine Nashville TN USA
Department of Biostatistics School of Public Health University of Washington Seattle WA USA
Department of Biostatistics University of Washington Seattle WA USA
Department of Biostatistics Vanderbilt University Medical Center Nashville TN USA
Department of Biostatistics Yale School of Public Health New Haven CT USA
Department of Clinical Genetics Karolinska University Hospital Stockholm Sweden
Department of Clinical Pathology University of Melbourne Melbourne VIC Australia
Department of Clinical Sciences Faculty of Medicine University of Barcelona Barcelona Spain
Department of Community Medicine and Epidemiology Lady Davis Carmel Medical Center Haifa Israel
Department of Computer Science Stanford University Stanford CA USA
Department of Epidemiology and Population Health Albert Einstein College of Medicine New York NY USA
Department of Epidemiology Harvard T H Chan School of Public Health Harvard University Boston MA USA
Department of Epidemiology Johns Hopkins Bloomberg School of Public Health Baltimore MD USA
Department of Epidemiology Nagoya University Graduate School of Medicine Nagoya Japan
Department of Epidemiology University of Washington School of Public Health Seattle WA USA
Department of Epidemiology University of Washington Seattle WA USA
Department of Family Medicine and Public Health University of California San Diego La Jolla CA USA
Department of General Surgery University Hospital Rostock Rostock Germany
Department of Genetics and Genome Sciences Case Western Reserve University Cleveland OH USA
Department of Genetics Stanford University Stanford CA USA
Department of Genetics Yale School of Medicine New Haven CT USA
Department of Health and Welfare Finnish Institute for Health and Welfare Helsinki Finland
Department of Hygiene and Epidemiology University of Ioannina School of Medicine Ioannina Greece
Department of Internal Medicine University of Utah Salt Lake City UT USA
Department of Laboratory Medicine and Pathology Mayo Clinic Arizona Scottsdale AZ USA
Department of Medical and Clinical Genetics University of Helsinki Helsinki Finland
Department of Medicine 1 University Hospital Dresden Technische Universität Dresden Dresden Germany
Department of Medicine and Epidemiology University of Pittsburgh Medical Center Pittsburgh PA USA
Department of Medicine Boston University School of Medicine Boston MA USA
Department of Medicine Keck School of Medicine University of Southern California Los Angeles CA USA
Department of Medicine Memorial Sloan Kettering Cancer Center New York NY USA
Department of Medicine Weill Cornell Medical College New York NY USA
Department of Molecular Medicine and Surgery Karolinska Institutet Stockholm Sweden
Department of Nutritional Sciences School of Public Health University of Michigan Ann Arbor MI USA
Department of Oncology University of Oxford Oxford UK
Department of Pathology Brigham and Women's Hospital Harvard Medical School Boston MA USA
Department of Pathology Central Finland Health Care District Jyväskylä Finland
Department of Pathology University of Michigan Ann Arbor MI USA
Department of Preventive Medicine Chonnam National University Medical School Gwangju South Korea
Department of Preventive Medicine Seoul National University College of Medicine Seoul South Korea
Department of Public Health and Primary Care University of Cambridge Cambridge UK
Department of Public Health and Welfare Finnish Institute for Health and Welfare Helsinki Finland
Department of Public Health Richard Doll Building University of Oxford Oxford UK
Department of Radiation Sciences Oncology Unit Umeå University Umeå Sweden
Department of Surgery Abdominal Centre Helsinki University Hospital Helsinki Finland
Department of Surgery University of Tennessee Health Science Center Memphis TN USA
Division of Biomedical Sciences Memorial University of Newfoundland St John ON Canada
Division of Cancer Epidemiology and Prevention Aichi Cancer Center Research Institute Nagoya Japan
Division of Cancer Epidemiology German Cancer Research Center Heidelberg Germany
Division of Gastroenterology Massachusetts General Hospital and Harvard Medical School Boston MA USA
Division of Genetics and Epidemiology Institute of Cancer Research London UK
Division of Human Nutrition and Health Wageningen University and Research Wageningen The Netherlands
Division of Human Nutrition Wageningen University and Research Wageningen The Netherlands
Division of Molecular and Clinical Epidemiology Aichi Cancer Center Research Institute Nagoya Japan
Division of Research Kaiser Permanente Northern California Oakland CA USA
Faculty of Medicine and Biomedical Center in Pilsen Charles University Pilsen Czech Republic
Faculty of Social Sciences Tampere University Tampere Finland
Folkhälsan Research Centre University of Helsinki Helsinki Finland
Fred Hutchinson Cancer Center Seattle WA USA
Genome Scale Biology Research Program University of Helsinki Helsinki Finland
Genomic Medicine and Family Cancer Clinic Royal Melbourne Hospital Parkville VIC Australia
Genomic Medicine Group Instituto de Investigacion Sanitaria de Santiago Santiago de Compostela Spain
Genomic Medicine Institute Cleveland Clinic Cleveland OH USA
German Cancer Consortium German Cancer Research Center Heidelberg Germany
Institute of Cancer Research Department of Medicine 1 Medical University Vienna Vienna Austria
Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden
Institute of Medical Genetics Cardiff University Cardiff UK
Institute of Nutritional Science University of Potsdam Potsdam Germany
Instituto de Investigación Sanitaria de Santiago de Compostela Santiago de Compostela Spain
Italian Institute for Genomic Medicine Candiolo Cancer Institute FPO IRCCS Candiolo Italy
Kaiser Permanente Washington Health Research Institute Seattle WA USA
Leeds Institute of Medical Research at St James's University of Leeds Leeds UK
Lothian Birth Cohorts group Department of Psychology University of Edinburgh Edinburgh UK
Lunenfeld Tanenbaum Research Institute Mount Sinai Hospital University of Toronto Toronto ON Canada
Menzies Institute for Medical Research University of Tasmania Hobart TAS Australia
MRC Clinical Trials Unit Medical Research Council Cardiff UK
MRC Human Genetics Unit Institute of Genomics and Cancer University of Edinburgh Edinburgh UK
Nuffield Department of Population Health University of Oxford Oxford UK
Oncology Data Analytics Program Catalan Institute of Oncology Barcelona Spain
Ontario Institute for Cancer Research Toronto ON Canada
Population and Cancer Prevention Program Case Comprehensive Cancer Center Cleveland OH USA
Preventative Medicine University of Southern California Los Angeles CA USA
Program in Computational Biology and Bioinformatics Yale University New Haven CT USA
Public Health Sciences Division Fred Hutchinson Cancer Center Seattle WA USA
Radcliffe Department of Medicine University of Oxford Oxford UK
Research Centre for Hauora and Health Massey University Wellington New Zealand
Ruth and Bruce Rappaport Faculty of Medicine Technion Israel Institute of Technology Haifa Israel
School of Public Health Sun Yat sen University Guangzhou China
School of Public Health University of Washington Seattle WA USA
Service de Génétique Médicale Centre Hospitalier Universitaire Nantes Nantes France
Slone Epidemiology Center at Boston University Boston MA USA
State Key Laboratory of Oncology in South China Cancer Center Sun Yat sen University Guangzhou China
Taipei Medical University Taipei Taiwan
University Medical Centre Hamburg Eppendorf University Cancer Centre Hamburg Hamburg Germany
Van Andel Research Institute Grand Rapids MI USA
Vanderbilt Genetics Institute Vanderbilt University Medical Center Nashville 37232 TN USA
Wallenberg Centre for Molecular Medicine Umeå University Umeå Sweden
Citace poskytuje Crossref.org
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- 700 1_
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- 700 1_
- $a Pai, Rish K $u Department of Laboratory Medicine and Pathology, Mayo Clinic Arizona, Scottsdale, AZ, USA
- 700 1_
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- 700 1_
- $a Haile, Robert W $u Division of Oncology, Department of Medicine, Cedars-Sinai Cancer Research Center for Health Equity, Los Angeles, CA, USA $1 https://orcid.org/0000000169021836
- 700 1_
- $a Gallinger, Steven $u Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada $1 https://orcid.org/0000000269989414
- 700 1_
- $a Woods, Michael O $u Division of Biomedical Sciences, Memorial University of Newfoundland, St. John, ON, Canada
- 700 1_
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- 700 1_
- $a Duggan, David $u City of Hope National Medical Center, Translational Genomics Research Institute, Phoenix, AZ, USA
- 700 1_
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- 700 1_
- $a Kaplan, Richard $u MRC Clinical Trials Unit, Medical Research Council, Cardiff, UK $1 https://orcid.org/0000000201898348
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- 700 1_
- $a Kerr, David $u Radcliffe Department of Medicine, University of Oxford, Oxford, UK $1 https://orcid.org/0000000178116722 $7 xx0260260
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Knekt, Paul $u Department of Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Cajuso, Tatiana $u Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland $u Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland $1 https://orcid.org/0000000263545572
- 700 1_
- $a Hänninen, Ulrika $u Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland $u Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland $1 https://orcid.org/0000000315580450
- 700 1_
- $a Kondelin, Johanna $u Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland $u Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland
- 700 1_
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- 700 1_
- $a Tanskanen, Tomas $u Department of Medical and Clinical Genetics, University of Helsinki, Helsinki, Finland $u Genome-Scale Biology Research Program, University of Helsinki, Helsinki, Finland
- 700 1_
- $a Renkonen-Sinisalo, Laura $u Department of Surgery, Abdominal Centre, Helsinki University Hospital, Helsinki, Finland
- 700 1_
- $a Männistö, Satu $u Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Helsinki, Finland $1 https://orcid.org/0000000286683046
- 700 1_
- $a Albanes, Demetrius $u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
- 700 1_
- $a Weinstein, Stephanie J $u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA $1 https://orcid.org/0000000238341535
- 700 1_
- $a Ruiz-Narvaez, Edward $u Department of Nutritional Sciences, School of Public Health, University of Michigan, Ann Arbor, MI, USA $1 https://orcid.org/0000000203395824
- 700 1_
- $a Palmer, Julie R $u Department of Medicine, Boston University School of Medicine, Boston, MA, USA $u Slone Epidemiology Center at Boston University, Boston, MA, USA
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Ulrich, Cornelia M $u Huntsman Cancer Institute and Department of Population Health Sciences, University of Utah, Salt Lake City, UT, USA
- 700 1_
- $a Siegel, Erin $u Cancer Epidemiology Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA $1 https://orcid.org/0000000317792510
- 700 1_
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- 700 1_
- $a Gsur, Andrea $u Institute of Cancer Research, Department of Medicine I, Medical University Vienna, Vienna, Austria $1 https://orcid.org/0000000297951528
- 700 1_
- $a Campbell, Peter T $u Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, NY, USA
- 700 1_
- $a Chang-Claude, Jenny $u Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany $u University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg, Hamburg, Germany $1 https://orcid.org/0000000189191971
- 700 1_
- $a Hoffmeister, Michael $u Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany $1 https://orcid.org/0000000283073197
- 700 1_
- $a Brenner, Hermann $u Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany $u Division of Preventive Oncology, German Cancer Research Center and National Center for Tumor Diseases, Heidelberg, Germany $u German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany $1 https://orcid.org/0000000261291572
- 700 1_
- $a Slattery, Martha L $u Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA
- 700 1_
- $a Potter, John D $u Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA $u Research Centre for Hauora and Health, Massey University, Wellington, New Zealand $1 https://orcid.org/0000000154391500
- 700 1_
- $a Tsilidis, Kostas K $u Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK $u Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
- 700 1_
- $a Schulze, Matthias B $u Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany $u Institute of Nutritional Science, University of Potsdam, Potsdam, Germany $1 https://orcid.org/0000000208305277
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Castellví-Bel, Sergi $u Gastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University of Barcelona, Barcelona, Spain $1 https://orcid.org/0000000312175097
- 700 1_
- $a Moreira, Leticia $u Gastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University of Barcelona, Barcelona, Spain $1 https://orcid.org/0000000245188591
- 700 1_
- $a Arndt, Volker $u Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany $1 https://orcid.org/0000000193208684
- 700 1_
- $a Shcherbina, Anna $u Department of Genetics, Stanford University, Stanford, CA, USA
- 700 1_
- $a Bishop, D Timothy $u Leeds Institute of Medical Research at St James's, University of Leeds, Leeds, UK $1 https://orcid.org/0000000287528785
- 700 1_
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- 700 1_
- $a Southey, Melissa C $u Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia $u Precision Medicine, School of Clinical Sciences at Monash Health, Monash University, Clayton, VIC, Australia $u Department of Clinical Pathology, University of Melbourne, Melbourne, VIC, Australia $1 https://orcid.org/0000000263139005
- 700 1_
- $a Idos, Gregory E $u Department of Medical Oncology and Center For Precision Medicine, City of Hope National Medical Center, Duarte, CA, USA
- 700 1_
- $a McDonnell, Kevin J $u Clalit National Cancer Control Center, Haifa, Israel $u Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel $u Department of Medical Oncology and Center For Precision Medicine, City of Hope National Medical Center, Duarte, CA, USA
- 700 1_
- $a Abu-Ful, Zomoroda $u Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel
- 700 1_
- $a Greenson, Joel K $u Clalit National Cancer Control Center, Haifa, Israel $u Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel $u Department of Pathology, University of Michigan, Ann Arbor, MI, USA
- 700 1_
- $a Shulman, Katerina $u Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel
- 700 1_
- $a Lejbkowicz, Flavio $u Clalit National Cancer Control Center, Haifa, Israel $u Department of Community Medicine and Epidemiology, Lady Davis Carmel Medical Center, Haifa, Israel $u Clalit Health Services, Personalized Genomic Service, Lady Davis Carmel Medical Center, Haifa, Israel
- 700 1_
- $a Offit, Kenneth $u Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA $u Department of Medicine, Weill Cornell Medical College, New York, NY, USA
- 700 1_
- $a Su, Yu-Ru $u Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA
- 700 1_
- $a Steinfelder, Robert $u Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA $1 https://orcid.org/0000000342048013
- 700 1_
- $a Keku, Temitope O $u Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, NC, USA
- 700 1_
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- 700 1_
- $a Hudson, Thomas J $u Ontario Institute for Cancer Research, Toronto, ON, Canada
- 700 1_
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- 700 1_
- $a Pearlman, Rachel $u Division of Human Genetics, Department of Internal Medicine, Ohio State University Comprehensive Cancer Center, Columbus, OH, USA
- 700 1_
- $a Berndt, Sonja I $u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA
- 700 1_
- $a Hayes, Richard B $u Division of Epidemiology, Department of Population Health, New York University School of Medicine, New York, NY, USA $1 https://orcid.org/000000020918661X
- 700 1_
- $a Martinez, Marie Elena $u Department of Family Medicine and Public Health, University of California San Diego, La Jolla, CA, USA $u Population Sciences, Disparities and Community Engagement, University of California San Diego Moores Cancer Center, La Jolla, CA, USA
- 700 1_
- $a Thomas, Sushma S $u Fred Hutchinson Cancer Center, Seattle, WA, USA
- 700 1_
- $a Pharoah, Paul D P $u Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
- 700 1_
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- 700 1_
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- 700 1_
- $a Lenz, Heinz-Josef $u Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA $1 https://orcid.org/0000000321789568 $7 xx0115135
- 700 1_
- $a White, Emily $u Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA $u Department of Epidemiology, University of Washington School of Public Health, Seattle, WA, USA
- 700 1_
- $a Li, Li $u Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH, USA
- 700 1_
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- 700 1_
- $a Pugh, Elizabeth $u Center for Inherited Disease Research, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
- 700 1_
- $a Shelford, Tameka $u Center for Inherited Disease Research, Department of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
- 700 1_
- $a Chan, Andrew T $u Broad Institute of Harvard and MIT, Cambridge, MA, USA $u Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA $u Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA $u Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA $u Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA $u Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA $1 https://orcid.org/0000000172846767
- 700 1_
- $a Cruz-Correa, Marcia $u Comprehensive Cancer Center, University of Puerto Rico, San Juan, Puerto Rico
- 700 1_
- $a Lindblom, Annika $u Department of Clinical Genetics, Karolinska University Hospital, Stockholm, Sweden $u Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden
- 700 1_
- $a Hunter, David J $u Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA $u Nuffield Department of Population Health, University of Oxford, Oxford, UK
- 700 1_
- $a Joshi, Amit D $u Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA $u Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA
- 700 1_
- $a Schafmayer, Clemens $u Department of General Surgery, University Hospital Rostock, Rostock, Germany
- 700 1_
- $a Scacheri, Peter C $u Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA
- 700 1_
- $a Kundaje, Anshul $u Department of Genetics, Stanford University, Stanford, CA, USA $u Department of Computer Science, Stanford University, Stanford, CA, USA $1 https://orcid.org/0000000330842287
- 700 1_
- $a Schoen, Robert E $u Department of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA $1 https://orcid.org/0000000171532766
- 700 1_
- $a Hampe, Jochen $u Department of Medicine I, University Hospital Dresden, Technische Universität Dresden, Dresden, Germany $1 https://orcid.org/0000000224216127
- 700 1_
- $a Stadler, Zsofia K $u Department of Medicine, Weill Cornell Medical College, New York, NY, USA $u Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, USA $1 https://orcid.org/0000000269852864
- 700 1_
- $a Vodicka, Pavel $u Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic $u Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic $u Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic
- 700 1_
- $a Vodickova, Ludmila $u Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic $u Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic $u Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic
- 700 1_
- $a Vymetalkova, Veronika $u Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic $u Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic $u Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic
- 700 1_
- $a Edlund, Christopher K $u Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
- 700 1_
- $a Gauderman, W James $u Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
- 700 1_
- $a Shibata, David $u Department of Surgery, University of Tennessee Health Science Center, Memphis, TN, USA
- 700 1_
- $a Toland, Amanda $u Departments of Cancer Biology and Genetics and Internal Medicine, Comprehensive Cancer Center, Ohio State University, Columbus, OH, USA $1 https://orcid.org/0000000202711792
- 700 1_
- $a Markowitz, Sanford $u Departments of Medicine and Genetics, Case Comprehensive Cancer Center, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH, USA $1 https://orcid.org/0000000153695254
- 700 1_
- $a Kim, Andre $u Department of Preventive Medicine, USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
- 700 1_
- $a Chanock, Stephen J $u Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA $1 https://orcid.org/0000000223243393
- 700 1_
- $a van Duijnhoven, Franzel $u Division of Human Nutrition and Health, Wageningen University and Research, Wageningen, The Netherlands
- 700 1_
- $a Feskens, Edith J M $u Division of Human Nutrition, Wageningen University and Research, Wageningen, The Netherlands $1 https://orcid.org/0000000158192488
- 700 1_
- $a Sakoda, Lori C $u Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA $u Division of Research, Kaiser Permanente Northern California, Oakland, CA, USA $1 https://orcid.org/0000000209005735
- 700 1_
- $a Gago-Dominguez, Manuela $u Genomic Medicine Group, Galician Public Foundation of Genomic Medicine, Servicio Galego de Saude, Santiago de Compostela, Spain $u Instituto de Investigación Sanitaria de Santiago de Compostela, Santiago de Compostela, Spain
- 700 1_
- $a Wolk, Alicja $u Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden $1 https://orcid.org/0000000173876845
- 700 1_
- $a Pardini, Barbara $u Candiolo Cancer Institute FPO-IRCCS, Candiolo, (TO), Italy $u Italian Institute for Genomic Medicine, Candiolo Cancer Institute FPO-IRCCS, Candiolo, (TO), Italy $1 https://orcid.org/0000000195714257
- 700 1_
- $a FitzGerald, Liesel M $u Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, VIC, Australia $u Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS, Australia
- 700 1_
- $a Lee, Soo Chin $u National University Cancer Institute, Singapore, Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore
- 700 1_
- $a Ogino, Shuji $u Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA $u Broad Institute of MIT and Harvard, Cambridge, MA, USA $u Cancer Immunology Program, Dana-Farber Harvard Cancer Center, Boston, MA, USA $u Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA $1 https://orcid.org/0000000239092323
- 700 1_
- $a Bien, Stephanie A $u Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA
- 700 1_
- $a Kooperberg, Charles $u Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA $1 https://orcid.org/0000000279868560
- 700 1_
- $a Li, Christopher I $u Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA
- 700 1_
- $a Lin, Yi $u Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA
- 700 1_
- $a Prentice, Ross $u Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA $u Department of Biostatistics, University of Washington, Seattle, WA, USA
- 700 1_
- $a Qu, Conghui $u Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA
- 700 1_
- $a Bézieau, Stéphane $u Service de Génétique Médicale, Centre Hospitalier Universitaire Nantes, Nantes, France $1 https://orcid.org/0000000300951319
- 700 1_
- $a Yamaji, Taiki $u Division of Epidemiology, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan
- 700 1_
- $a Sawada, Norie $u Division of Cohort Research, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan $1 https://orcid.org/0000000299361476
- 700 1_
- $a Iwasaki, Motoki $u Division of Epidemiology, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan $u Division of Cohort Research, National Cancer Center Institute for Cancer Control, National Cancer Center, Tokyo, Japan
- 700 1_
- $a Le Marchand, Loic $u Cancer Center, University of Hawaii, Honolulu, HI, USA
- 700 1_
- $a Wu, Anna H $u Preventative Medicine, University of Southern California, Los Angeles, CA, USA
- 700 1_
- $a Qu, Chenxu $u USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
- 700 1_
- $a McNeil, Caroline E $u USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
- 700 1_
- $a Coetzee, Gerhard $u Van Andel Research Institute, Grand Rapids, MI, USA $1 https://orcid.org/0000000188208364
- 700 1_
- $a Hayward, Caroline $u MRC Human Genetics Unit, Institute of Genomics and Cancer, University of Edinburgh, Edinburgh, UK $1 https://orcid.org/0000000294059550
- 700 1_
- $a Deary, Ian J $u Lothian Birth Cohorts group, Department of Psychology, University of Edinburgh, Edinburgh, UK $1 https://orcid.org/000000021733263X $7 js20101005001
- 700 1_
- $a Harris, Sarah E $u Lothian Birth Cohorts group, Department of Psychology, University of Edinburgh, Edinburgh, UK $1 https://orcid.org/0000000249415106
- 700 1_
- $a Theodoratou, Evropi $u Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK $1 https://orcid.org/0000000158879132
- 700 1_
- $a Reid, Stuart $u Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK
- 700 1_
- $a Walker, Marion $u Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK
- 700 1_
- $a Ooi, Li Yin $u Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK $u Department of Pathology, National University Hospital, National University Health System, Singapore, Singapore $1 https://orcid.org/0000000255882130
- 700 1_
- $a Lau, Ken S $u Epithelial Biology Center and Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN, USA $1 https://orcid.org/0000000184380319
- 700 1_
- $a Zhao, Hongyu $u Department of Biostatistics, Yale School of Public Health, New Haven, CT, USA $u Department of Genetics, Yale School of Medicine, New Haven, CT, USA $u Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT, USA $1 https://orcid.org/0000000311959607
- 700 1_
- $a Hsu, Li $u Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, WA, USA $u Department of Biostatistics, School of Public Health, University of Washington, Seattle, WA, USA $1 https://orcid.org/0000000181684712
- 700 1_
- $a Cai, Qiuyin $u Division of Epidemiology, Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN, USA $1 https://orcid.org/0000000293845648
- 700 1_
- $a Dunlop, Malcolm G $u Colon Cancer Genetics Group, Medical Research Council Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK $1 https://orcid.org/0000000230335851
- 700 1_
- $a Gruber, Stephen B $u Department of Medical Oncology and Center For Precision Medicine, City of Hope National Medical Center, Duarte, CA, USA $1 https://orcid.org/0000000186567822
- 700 1_
- $a Houlston, Richard S $u Division of Genetics and Epidemiology, Institute of Cancer Research, London, UK $1 https://orcid.org/0000000252680242
- 700 1_
- $a Moreno, Victor $u Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute, Barcelona, Spain $u Consortium for Biomedical Research in Epidemiology and Public Health, Madrid, Spain $u Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain $u Oncology Data Analytics Program, Catalan Institute of Oncology, Barcelona, Spain $1 https://orcid.org/0000000228185487
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