• Je něco špatně v tomto záznamu ?

Comparing the antibacterial and healing properties of medical-grade honey and silver-based wound care products in burns

BKHL. Boekema, D. Chrysostomou, G. Ciprandi, A. Elgersma, M. Vlig, A. Pokorná, LJF. Peters, NAJ. Cremers

. 2024 ; 50 (3) : 597-610. [pub] 20231028

Jazyk angličtina Země Nizozemsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc24014505

Burns are a major global healthcare concern, often complicated by the presence of bacteria such as Pseudomonas aeruginosa in the wounds. Silver-based dressings are commonly used in the treatment of burns but can cause skin irritation and delay healing time. Medical-grade honey (MGH) provides an interesting alternative. This study investigated the antimicrobial effects and possible cytotoxicity of L-Mesitran Soft (MGH-gel) and its individual components, Medihoney (Manuka), Flammazine (silver sulphadiazine), and silver nitrate (AgNO3) in an ex vivo human burn wound model. Bacterial survival and wound healing parameters, including re-epithelialization and keratinocyte proliferation were assessed. L-Mesitran, Flammazine, and AgNO3 reduced P. aeruginosa numbers below detection levels. L-Mesitran Soft exhibited a significantly stronger antimicrobial effect compared to Medihoney. The individual components of L-Mesitran contributed significantly to its antibacterial efficacy, thus suggesting synergistic activities. Moreover, L-Mesitran, Flammazine, and AgNO3 slightly inhibited re-epithelialization while Medihoney treatment resulted in a complete lack of re-epithelialization and keratinocyte proliferation. Furthermore, clinical cases illustrated the effectiveness of MGH therapy in infected burns. Overall, L-Mesitran Soft had similar effects as silver-based products on bacterial load and epidermal regeneration, but outperformed Medihoney. Therefore, supplemented MGH could be used as an effective alternative to silver-based dressings for P. aeruginosa-infected burns.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc24014505
003      
CZ-PrNML
005      
20240905133330.0
007      
ta
008      
240725s2024 ne f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.burns.2023.10.009 $2 doi
035    __
$a (PubMed)37940425
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a ne
100    1_
$a Boekema, Bouke K H L $u Preclinical Research, Association of Dutch Burn Centers (ADBC), P.O. Box 1015, 1940 AE Beverwijk, the Netherlands; Plastic, Reconstructive and Hand Surgery, AUMC, Amsterdam, the Netherlands
245    10
$a Comparing the antibacterial and healing properties of medical-grade honey and silver-based wound care products in burns / $c BKHL. Boekema, D. Chrysostomou, G. Ciprandi, A. Elgersma, M. Vlig, A. Pokorná, LJF. Peters, NAJ. Cremers
520    9_
$a Burns are a major global healthcare concern, often complicated by the presence of bacteria such as Pseudomonas aeruginosa in the wounds. Silver-based dressings are commonly used in the treatment of burns but can cause skin irritation and delay healing time. Medical-grade honey (MGH) provides an interesting alternative. This study investigated the antimicrobial effects and possible cytotoxicity of L-Mesitran Soft (MGH-gel) and its individual components, Medihoney (Manuka), Flammazine (silver sulphadiazine), and silver nitrate (AgNO3) in an ex vivo human burn wound model. Bacterial survival and wound healing parameters, including re-epithelialization and keratinocyte proliferation were assessed. L-Mesitran, Flammazine, and AgNO3 reduced P. aeruginosa numbers below detection levels. L-Mesitran Soft exhibited a significantly stronger antimicrobial effect compared to Medihoney. The individual components of L-Mesitran contributed significantly to its antibacterial efficacy, thus suggesting synergistic activities. Moreover, L-Mesitran, Flammazine, and AgNO3 slightly inhibited re-epithelialization while Medihoney treatment resulted in a complete lack of re-epithelialization and keratinocyte proliferation. Furthermore, clinical cases illustrated the effectiveness of MGH therapy in infected burns. Overall, L-Mesitran Soft had similar effects as silver-based products on bacterial load and epidermal regeneration, but outperformed Medihoney. Therefore, supplemented MGH could be used as an effective alternative to silver-based dressings for P. aeruginosa-infected burns.
650    _2
$a lidé $7 D006801
650    _2
$a stříbrná sůl sulfadiazinu $x farmakologie $x terapeutické užití $7 D012837
650    12
$a med $7 D006722
650    12
$a popálení $x farmakoterapie $x komplikace $7 D002056
650    _2
$a hojení ran $7 D014945
650    _2
$a antibakteriální látky $x farmakologie $x terapeutické užití $7 D000900
650    _2
$a Bacteria $7 D001419
655    _2
$a časopisecké články $7 D016428
700    1_
$a Chrysostomou, Daniela $u Wound Clinic Health@45, Linksfield Road 45, Dowerglen, Johannesburg 1612, South Africa; Department of Health Sciences, Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Public Health, Faculty of Medicine, Masaryk University, Brno, Czech Republic
700    1_
$a Ciprandi, Guido $u Bambino Gesu' Children's Hospital, Research Institute Division of Plastic and Maxillofacial Surgery, Department of Surgery, Sant' Onofrio Square 4, 00165 Rome, Italy
700    1_
$a Elgersma, Anouk $u Preclinical Research, Association of Dutch Burn Centers (ADBC), P.O. Box 1015, 1940 AE Beverwijk, the Netherlands
700    1_
$a Vlig, Marcel $u Preclinical Research, Association of Dutch Burn Centers (ADBC), P.O. Box 1015, 1940 AE Beverwijk, the Netherlands
700    1_
$a Pokorná, Andrea $u Department of Health Sciences, Faculty of Medicine, Masaryk University, Brno, Czech Republic; Department of Public Health, Faculty of Medicine, Masaryk University, Brno, Czech Republic; College of Polytechnics Jihlava, Jihlava, Czech Republic
700    1_
$a Peters, Linsey J F $u Triticum Exploitatie BV, Sleperweg 44, 6222 NK Maastricht, the Netherlands
700    1_
$a Cremers, Niels A J $u Triticum Exploitatie BV, Sleperweg 44, 6222 NK Maastricht, the Netherlands; Department of Gynecology and Obstetrics, Maastricht University Medical Center, 6202 AZ Maastricht, the Netherlands. Electronic address: niels.cremers@mumc.nl
773    0_
$w MED00000977 $t Burns $x 1879-1409 $g Roč. 50, č. 3 (2024), s. 597-610
856    41
$u https://pubmed.ncbi.nlm.nih.gov/37940425 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20240725 $b ABA008
991    __
$a 20240905133324 $b ABA008
999    __
$a ok $b bmc $g 2143953 $s 1226371
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2024 $b 50 $c 3 $d 597-610 $e 20231028 $i 1879-1409 $m Burns $n Burns $x MED00000977
LZP    __
$a Pubmed-20240725

Najít záznam

Citační ukazatele

Možnosti archivace