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Gut microbiota alteration and its association with immune function in post-COVID-19 patients
J. Cai, J. Xu, Y. Tan, Y. Xiang, Z. Li, J. Zheng, Y. Li
Jazyk angličtina Země Česko
Typ dokumentu časopisecké články
Grantová podpora
2021MSXM253
Chongqing Science and Health Joint Medical Research Foundation
2020FYYX232
Chongqing Science and Health Joint Medical Research Foundation
- MeSH
- Bacteria klasifikace genetika izolace a purifikace MeSH
- buňky NK imunologie MeSH
- COVID-19 * imunologie mikrobiologie MeSH
- dospělí MeSH
- feces mikrobiologie virologie MeSH
- interleukin-1beta MeSH
- interleukin-8 MeSH
- lidé středního věku MeSH
- lidé MeSH
- RNA ribozomální 16S * genetika MeSH
- SARS-CoV-2 * imunologie MeSH
- senioři MeSH
- střevní mikroflóra * MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
To reveal the variation of gut microbiota and its association with immune function in cured patients with coronavirus 2019 (COVID-19) disease, gut microbiota of patients discharged from hospital for 20 ~ 23 months and healthy volunteers was analyzed by high throughput 16S rRNA sequencing. The diversity and abundance were compared, and the correlation with immunity factors was investigated, and changes in the content of 6 genera microorganisms with proportion higher than 0.1% were revealed in patients with COVID-19 disease: reduced content of Subdoligranulum, Haemophilus, Coprococcus, Eubacterium vertriosum group, and Lachnospiraceae ND3007 group and increased content of Hungatella. NK cells were negatively correlated to Subdoligranulum, while CD8 cells were positively correlated to Subdoligranulum but negative to Hungatella. IL-8 concentration was negatively correlated to Subdoligranulum, Haemophilus, Coprococcus, Eubacterium vertriosum group, and Lachnospiraceae ND3007 group but positively to Hungatella, while IL-1β concentration was negatively correlated to Haemophilus and Eubacterium ventriosum group but positively to Hungatella. The variation of probiotics and potential pathogenic bacteria implies a higher risk in diseases and inflammation, and the modulation of the gut microbiota may help the healing of COVID-19 patients.
College of Public Health Chongqing Medical University Chongqing 400016 China
Department of Neurology Chongqing Red Cross Hospital Chongqing 400020 China
Citace poskytuje Crossref.org
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- $a To reveal the variation of gut microbiota and its association with immune function in cured patients with coronavirus 2019 (COVID-19) disease, gut microbiota of patients discharged from hospital for 20 ~ 23 months and healthy volunteers was analyzed by high throughput 16S rRNA sequencing. The diversity and abundance were compared, and the correlation with immunity factors was investigated, and changes in the content of 6 genera microorganisms with proportion higher than 0.1% were revealed in patients with COVID-19 disease: reduced content of Subdoligranulum, Haemophilus, Coprococcus, Eubacterium vertriosum group, and Lachnospiraceae ND3007 group and increased content of Hungatella. NK cells were negatively correlated to Subdoligranulum, while CD8 cells were positively correlated to Subdoligranulum but negative to Hungatella. IL-8 concentration was negatively correlated to Subdoligranulum, Haemophilus, Coprococcus, Eubacterium vertriosum group, and Lachnospiraceae ND3007 group but positively to Hungatella, while IL-1β concentration was negatively correlated to Haemophilus and Eubacterium ventriosum group but positively to Hungatella. The variation of probiotics and potential pathogenic bacteria implies a higher risk in diseases and inflammation, and the modulation of the gut microbiota may help the healing of COVID-19 patients.
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