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Cerebrovascular and Alzheimer's disease biomarkers in dementia with Lewy bodies and other dementias
A. Rennie, U. Ekman, S. Shams, L. Rydén, J. Samuelsson, A. Zettergren, S. Kern, K. Oppedal, F. Blanc, J. Hort, S. Garcia-Ptacek, A. Antonini, AW. Lemstra, A. Padovani, MG. Kramberger, I. Rektorová, Z. Walker, J. Snædal, M. Pardini, JP. Taylor, L....
Status neindexováno Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články
NLK
Directory of Open Access Journals
od 2019
PubMed Central
od 2019
Oxford Journals Open Access Collection
od 2019-07-01
ROAD: Directory of Open Access Scholarly Resources
od 2019
- Publikační typ
- časopisecké články MeSH
Co-pathologies are common in dementia with Lewy bodies and other dementia disorders. We investigated cerebrovascular and Alzheimer's disease co-pathologies in patients with dementia with Lewy bodies in comparison with patients with mild cognitive impairment, Alzheimer's disease, mixed dementia, vascular dementia or Parkinson's disease with dementia and cognitively unimpaired participants. We assessed the association of biomarkers of cerebrovascular and Alzheimer's disease co-pathologies with medial temporal atrophy and global cognitive performance. Additionally, we evaluated whether the findings were specific to dementia with Lewy bodies. We gathered a multi-cohort dataset of 4549 participants (dementia with Lewy bodies = 331, cognitively unimpaired = 1505, mild cognitive impairment = 1489, Alzheimer's disease = 708, mixed dementia = 268, vascular dementia = 148, Parkinson's disease with dementia = 120) from the MemClin Study, Karolinska Imaging in Dementia Study, Gothenburg H70 Birth Cohort Studies and the European DLB Consortium. Cerebrovascular co-pathology was assessed with visual ratings of white matter hyperintensities using the Fazekas scale through structural imaging. Alzheimer's disease biomarkers of β-amyloid and phosphorylated tau were assessed in the cerebrospinal fluid for a subsample (N = 2191). Medial temporal atrophy was assessed with visual ratings and global cognition with the mini-mental state examination. Differences and associations were assessed through regression models, including interaction terms. In dementia with Lewy bodies, 43% had a high white matter hyperintensity load, which was significantly higher than that in cognitively unimpaired (14%), mild cognitive impairment (26%) and Alzheimer's disease (27%), but lower than that in vascular dementia (62%). In dementia with Lewy bodies, white matter hyperintensities were associated with medial temporal atrophy, and the interaction term showed that this association was stronger than that in cognitively unimpaired and mixed dementia. However, the association between white matter hyperintensities and medial temporal atrophy was non-significant when β-amyloid was included in the model. Instead, β-amyloid predicted medial temporal atrophy in dementia with Lewy bodies, in contrast to the findings in mild cognitive impairment where medial temporal atrophy scores were independent of β-amyloid. Dementia with Lewy bodies had the lowest performance on global cognition, but this was not associated with white matter hyperintensities. In Alzheimer's disease, global cognitive performance was lower in patients with more white matter hyperintensities. We conclude that white matter hyperintensities are common in dementia with Lewy bodies and are associated with more atrophy in medial temporal lobes, but this association depended on β-amyloid-related pathology in our cohort. The associations between biomarkers were overall stronger in dementia with Lewy bodies than in some of the other diagnostic groups.
Ageing Epidemiology Research Unit School of Public Health Imperial College London SW7 2AZ London UK
Aging and Inflammation Theme Karolinska University Hospital 171 76 Stockholm Sweden
Applied Neuroscience Research Group CEITEC Masaryk University 625 00 Brno Czech Republic
Center for Age Related Medicine Stavanger University Hospital 4011 Stavanger Norway
Centre for Ageing and Health University of Gothenburg 413 46 Gothenburg Sweden
Department of Clinical Neuroscience Karolinska Institutet 171 77 Stockholm Sweden
Department of Neurology IRCCS Ospedale Policlinico San Martino 16132 Genoa Italy
Department of Neurology University Medical Center 1000 Ljubljana Slovenia
Department of Radiology Karolinska University Hospital 171 76 Stockholm Sweden
Department of Radiology Stanford University Stanford 94305 5105 CA USA
Division of Psychiatry University College London W1T 7NF London UK
Facultad de Ciencias de la Salud Universidad Fernando Pessoa Canarias 35016 Las Palmas España
Institute of Public Health and Clinical Nutrition University of Eastern Finland 70211 Kuopio Finland
Medical Faculty University of Ljubljana 1000 Ljubljana Slovenia
Memory Clinic Landspitali 105 Reykjavik Iceland
Parkinson and Movement Disorders Unit Study Center on Neurodegeneration 35129 Padova Italy
St Margaret's Hospital Essex Partnership University NHS Foundation Trust CM16 6TN Essex UK
The Norwegian Centre for Movement Disorders Stavanger University Hospital 4011 Stavanger Norway
Citace poskytuje Crossref.org
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