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Distribution of mechanical properties of native human ligamentum flavum depending on histopathological changes
F. Samal, V. Cerny, P. Kujal, J. Jezek, J. Skala-Rosenbaum, J. Sepitka
Language English Country England, Great Britain
Document type Journal Article
- MeSH
- Lumbar Vertebrae * pathology MeSH
- Biomechanical Phenomena MeSH
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Ligamentum Flavum * pathology MeSH
- Stress, Mechanical MeSH
- Aged MeSH
- Spinal Stenosis * pathology MeSH
- Intervertebral Disc Displacement * pathology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
This study aimed to characterize the mechanical properties of native human ligamentum flavum (LF) and correlate them with histopathological changes. Mechanical property gradients across the cranial, medial, and caudal regions of LF were mapped and compared with histological sections. We also compared lumbar spinal stenosis (LSS) samples with disc herniation (DH) samples as reference material to identify differences in mechanical properties and histopathological features. Our results revealed significant heterogeneity in LF mechanical properties, with local variations correlating with specific histopathological changes such as chondroid metaplasia and loss of elastic fibers. These findings underscore the importance of considering LF heterogeneity in mechanical characterization and provide insights into its behavior under pathological conditions.
References provided by Crossref.org
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- $a Samal, Filip $u Department of Neurosurgery, Third Medical Faculty of Charles University and University Hospital Kralovske Vinohrady, Prague, Czech Republic
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- $a This study aimed to characterize the mechanical properties of native human ligamentum flavum (LF) and correlate them with histopathological changes. Mechanical property gradients across the cranial, medial, and caudal regions of LF were mapped and compared with histological sections. We also compared lumbar spinal stenosis (LSS) samples with disc herniation (DH) samples as reference material to identify differences in mechanical properties and histopathological features. Our results revealed significant heterogeneity in LF mechanical properties, with local variations correlating with specific histopathological changes such as chondroid metaplasia and loss of elastic fibers. These findings underscore the importance of considering LF heterogeneity in mechanical characterization and provide insights into its behavior under pathological conditions.
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- $a Cerny, Vojtech $u Faculty of Mechanical Engineering, Czech Technical University in Prague, Technicka 4, 16607 Prague, Czech Republic
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- $a Kujal, Petr $u Department of Pathology, Third Medical Faculty of Charles University and University Hospital Kralovske Vinohrady, Prague, Czech Republic
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- $a Skala-Rosenbaum, Jiri $u Department of Orthopedics and Traumatology, Third Medical Faculty of Charles University and University Hospital Kralovske Vinohrady, Srobarova 50, Praha, 10, 100 34 Prague, Czech Republic
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- $a Sepitka, Josef $u Faculty of Mechanical Engineering, Czech Technical University in Prague, Technicka 4, 16607 Prague, Czech Republic $1 https://orcid.org/0000000185239659
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