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Garcinol in gastrointestinal cancer prevention: recent advances and future prospects

N. Patwa, R. Chauhan, A. Chauhan, M. Kumar, S. Ramniwas, DM. Mathkor, AK. Saini, HS. Tuli, S. Haque, P. Slama

. 2024 ; 150 (7) : 370. [pub] 20240727

Jazyk angličtina Země Německo

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc24019674

Gastrointestinal cancers continue to pose a significant global health challenge, with millions of new cases diagnosed each year. Despite advancements in treatment, the prognosis for many patients remains poor. This article explores the potential of garcinol, a polyisoprenylated benzophenone found in various Garcinia species, as a therapeutic agent against gastrointestinal malignancies. The objective is to review recent research on garcinol's anticancer properties, its mechanisms of action, and safety aspects. Garcinol exhibits anticancer effects in esophageal, gastric, colorectal, pancreatic, and liver cancers by inhibiting metastasis, inducing apoptosis, and targeting key molecular pathways in cancer progression. Nanotechnology is explored as a means to enhance garcinol delivery and efficacy. Safety assessments suggest a promising toxicity profile. Garcinol shows significant potential as a natural therapeutic agent for gastrointestinal cancers, and future research is needed on optimizing its delivery, exploring synergistic combinations, and conducting clinical trials to validate its efficacy and safety for clinical applications.

Citace poskytuje Crossref.org

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$a Chauhan, Ritu $u Department of Biotechnology, Graphic Era Deemed to be University, Dehradun, Uttarakhand, 248002, India
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$a Chauhan, Abhishek $u Amity Institute of Environmental Toxicology Safety and Management, Amity University, Noida, U.P, India
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$a Kumar, Manoj $u Department of Chemistry, Maharishi Markandeshwar University, Sadopur-Ambala, 134007, Haryana, India
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$a Ramniwas, Seema $u University Centre for Research and Development, University Institute of Pharmaceutical Sciences, Chandigarh University, Gharuan, Mohali, 140413, India
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