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An in-vivo treatment monitoring system for ion-beam radiotherapy based on 28 Timepix3 detectors

L. Kelleter, L. Marek, G. Echner, P. Ochoa-Parra, M. Winter, S. Harrabi, J. Jakubek, O. Jäkel, J. Debus, M. Martisikova

. 2024 ; 14 (1) : 15452. [pub] 20240704

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc24019808

Grantová podpora
Internal ID National Center for Tumor Diseases (NCT Heidelberg)
Internal ID National Center for Tumor Diseases (NCT Heidelberg)
International PhD program Deutsches Krebsforschungszentrum

Ion-beam radiotherapy is an advanced cancer treatment modality offering steep dose gradients and a high biological effectiveness. These gradients make the therapy vulnerable to patient-setup and anatomical changes between treatment fractions, which may go unnoticed. Charged fragments from nuclear interactions of the ion beam with the patient tissue may carry information about the treatment quality. Currently, the fragments escape the patient undetected. Inter-fractional in-vivo treatment monitoring based on these charged nuclear fragments could make ion-beam therapy safer and more efficient. We developed an ion-beam monitoring system based on 28 hybrid silicon pixel detectors (Timepix3) to measure the distribution of fragment origins in three dimensions. The system design choices as well as the ion-beam monitoring performance measurements are presented in this manuscript. A spatial resolution of 4mm along the beam axis was achieved for the measurement of individual fragment origins. Beam-range shifts of 1.5mm were identified in a clinically realistic treatment scenario with an anthropomorphic head phantom. The monitoring system is currently being used in a prospective clinical trial at the Heidelberg Ion Beam Therapy Centre for head-and-neck as well as central nervous system cancer patients.

Citace poskytuje Crossref.org

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