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Connectome architecture shapes large-scale cortical alterations in schizophrenia: a worldwide ENIGMA study
F. Georgiadis, S. Larivière, D. Glahn, LE. Hong, P. Kochunov, B. Mowry, C. Loughland, C. Pantelis, FA. Henskens, MJ. Green, MJ. Cairns, PT. Michie, PE. Rasser, S. Catts, P. Tooney, RJ. Scott, U. Schall, V. Carr, Y. Quidé, A. Krug, F. Stein, I....
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články
Grantová podpora
R01 MH118695
NIMH NIH HHS - United States
R21 MH097196
NIMH NIH HHS - United States
R01 EB015611
NIBIB NIH HHS - United States
RF1 NS114628
NINDS NIH HHS - United States
S10 OD023696
NIH HHS - United States
I01 CX000227
CSRD VA - United States
R01 MH112583
NIMH NIH HHS - United States
NLK
ProQuest Central
od 2000-01-01 do Před 1 rokem
Open Access Digital Library
od 1997-01-01
Health & Medicine (ProQuest)
od 2000-01-01 do Před 1 rokem
Psychology Database (ProQuest)
od 2000-01-01 do Před 1 rokem
- MeSH
- dospělí MeSH
- konektom * metody MeSH
- lidé středního věku MeSH
- lidé MeSH
- magnetická rezonanční tomografie * metody MeSH
- mladý dospělý MeSH
- mozek patologie patofyziologie MeSH
- mozková kůra patologie patofyziologie MeSH
- nervová síť patologie patofyziologie diagnostické zobrazování MeSH
- nervové dráhy patofyziologie patologie MeSH
- schizofrenie * patologie patofyziologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Schizophrenia is a prototypical network disorder with widespread brain-morphological alterations, yet it remains unclear whether these distributed alterations robustly reflect the underlying network layout. We tested whether large-scale structural alterations in schizophrenia relate to normative structural and functional connectome architecture, and systematically evaluated robustness and generalizability of these network-level alterations. Leveraging anatomical MRI scans from 2439 adults with schizophrenia and 2867 healthy controls from 26 ENIGMA sites and normative data from the Human Connectome Project (n = 207), we evaluated structural alterations of schizophrenia against two network susceptibility models: (i) hub vulnerability, which examines associations between regional network centrality and magnitude of disease-related alterations; (ii) epicenter mapping, which identifies regions whose typical connectivity profile most closely resembles the disease-related morphological alterations. To assess generalizability and specificity, we contextualized the influence of site, disease stages, and individual clinical factors and compared network associations of schizophrenia with that found in affective disorders. Our findings show schizophrenia-related cortical thinning is spatially associated with functional and structural hubs, suggesting that highly interconnected regions are more vulnerable to morphological alterations. Predominantly temporo-paralimbic and frontal regions emerged as epicenters with connectivity profiles linked to schizophrenia's alteration patterns. Findings were robust across sites, disease stages, and related to individual symptoms. Moreover, transdiagnostic comparisons revealed overlapping epicenters in schizophrenia and bipolar, but not major depressive disorder, suggestive of a pathophysiological continuity within the schizophrenia-bipolar-spectrum. In sum, cortical alterations over the course of schizophrenia robustly follow brain network architecture, emphasizing marked hub susceptibility and temporo-frontal epicenters at both the level of the group and the individual. Subtle variations of epicenters across disease stages suggest interacting pathological processes, while associations with patient-specific symptoms support additional inter-individual variability of hub vulnerability and epicenters in schizophrenia. Our work outlines potential pathways to better understand macroscale structural alterations, and inter- individual variability in schizophrenia.
Department of child and adolescent psychiatry TU Dresden Dresden Germany
Department of Pediatric Neurology University of California Irvine Irvine CA USA
Department of Psychiatry and Behavioral Health the Ohio State University Columbus OH USA
Department of Psychiatry and Human Behavior University of California Irvine Irvine CA USA
Department of Psychiatry and Mental Health University of Cape Town Cape Town South Africa
Department of Psychiatry and Psychotherapy Philipps University Marburg Marburg Germany
Department of Psychiatry Harvard Medical School Boston MA USA
Department of Psychiatry Pontificia Universidad Católica de Chile Santiago Chile
Department of Psychiatry University of Lübeck Lübeck Germany
Department of Psychiatry University of Marburg Rudolf Bultmann Str 8 35039 Marburg Germany
Division of Adult Psychiatry Department of Psychiatry Geneva University Hospitals Geneva Switzerland
Faculty of Medicine University of Queensland St Lucia QLD Australia
FIDMAG Germanes Hospitalàries Research Foundation and CIBERSAM ISCIII Barcelona Spain
Forschungszentrum Jülich Jülich Germany
Hospital Universitario Virgen del Rocío IBiS CSIC Universidad de Sevilla Seville Spain
Hunter Medical Research Institute Newcastle NSW Australia
Institut d'Investigacions Biomèdiques August Pi i Sunyer Barcelona Spain
Institute for Translational Psychiatry University of Münster Münster Germany
Max Planck Institute for Cognitive and Brain Sciences Leipzig Germany
McGill University Montreal Neurological Institute Montreal QC Canada
Mental Health Research Center Moscow Russian Federation
Minneapolis VA Health Care System Minneapolis MN USA
National Institute of Mental Health Topolova 748 250 67 Klecany Czech Republic
Queensland Brain Institute The University of Queensland St Lucia QLD Australia
Santa Lucia Foundation IRCCS Santa Lucia Rome Italy
School of Biomedical Science and Pharmacy University of Newcastle Newcastle NSW Australia
School of Clinical Medicine Discipline of Psychiatry UNSW Sydney Sydney NSW Australia
School of Medicine and Public Health University of Newcastle Newcastle NSW Australia
School of Medicine and Public Health University of Newcastle Newcastle NSW USA
School of Psychological Sciences University of Newcastle Newcastle NSW Australia
University of Basel Department of Psychiatry Basel Switzerland
University of Minnesota Department of Psychiatry and Behavioral Sciences Minneapolis MN USA
University of Minnesota Department of Psychology Minneapolis MN USA
University of Naples Department of Neuroscience Naples Italy
University of Pennsylvania Perelman School of Medicine Philadelphia PA USA
Citace poskytuje Crossref.org
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