Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

The influence of depth of sedation on motor evoked potentials monitoring in youth from 4 to 23 years old: preliminary data from a prospective observational study

J. Hudec, M. Kosinová, T. Prokopová, H. Zelinková, K. Hudáček, M. Repko, R. Gál, P. Štourač

. 2024 ; 11 (-) : 1471450. [pub] 20241029

Status not-indexed Language English Country Switzerland

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc25002263

INTRODUCTION: The influence of various levels of sedation depth on motor evoked potentials (MEP) reproducibility in youth is still unclear because of a lack of data. We tested the hypothesis that a deeper level of total intravenous anesthesia (TIVA) [bispectral index (BIS) 40 ± 5 compared to 60 ± 5] can affect surgeon-directed MEP and their interpretation in youths. METHODS: All patients received TIVA combined with propofol and remifentanil. TIVA was initially maintained at a BIS level of 60 ± 5. The sedation anesthesia was deepened to BIS level 40 ± 5 before the skin incision. MEP were recorded and interpreted at both BIS levels. The primary endpoint was to evaluate the effect of the depth of sedation on the MEP reproducibility directed and interpreted by the surgical team in each patient separately. The secondary endpoint was to compare the relativized MEP parameters (amplitude and latency) in percentage at various levels of sedation in each patient separately. We planned to enroll 150 patients. Due to the COVID-19 pandemic, we decided to analyze the results of the first 50 patients. RESULTS: The surgical team successfully recorded and interpreted MEP in all 50 enrolled patients in both levels of sedation depth without any clinical doubts. The MEP parameters at BIS level 40 ± 5, proportionally compared with the baseline, were latency 104% (97-110%) and the MEP amplitudes 84.5% (51-109%). CONCLUSION: Preliminary data predict that deeper sedation (BIS 40 ± 5) does not affect the surgical team's interpretation of MEP in youth patients. These results support that surgeon-directed MEP may be an alternative when neurophysiologists are unavailable.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc25002263
003      
CZ-PrNML
005      
20250123101906.0
007      
ta
008      
250117e20241029sz f 000 0|eng||
009      
AR
024    7_
$a 10.3389/fmed.2024.1471450 $2 doi
035    __
$a (PubMed)39534220
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Hudec, Jan $u Department of Anesthesiology and Intensive Care Medicine, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia $u Department of Simulation Medicine, Faculty of Medicine, Masaryk University, Brno, Czechia
245    14
$a The influence of depth of sedation on motor evoked potentials monitoring in youth from 4 to 23 years old: preliminary data from a prospective observational study / $c J. Hudec, M. Kosinová, T. Prokopová, H. Zelinková, K. Hudáček, M. Repko, R. Gál, P. Štourač
520    9_
$a INTRODUCTION: The influence of various levels of sedation depth on motor evoked potentials (MEP) reproducibility in youth is still unclear because of a lack of data. We tested the hypothesis that a deeper level of total intravenous anesthesia (TIVA) [bispectral index (BIS) 40 ± 5 compared to 60 ± 5] can affect surgeon-directed MEP and their interpretation in youths. METHODS: All patients received TIVA combined with propofol and remifentanil. TIVA was initially maintained at a BIS level of 60 ± 5. The sedation anesthesia was deepened to BIS level 40 ± 5 before the skin incision. MEP were recorded and interpreted at both BIS levels. The primary endpoint was to evaluate the effect of the depth of sedation on the MEP reproducibility directed and interpreted by the surgical team in each patient separately. The secondary endpoint was to compare the relativized MEP parameters (amplitude and latency) in percentage at various levels of sedation in each patient separately. We planned to enroll 150 patients. Due to the COVID-19 pandemic, we decided to analyze the results of the first 50 patients. RESULTS: The surgical team successfully recorded and interpreted MEP in all 50 enrolled patients in both levels of sedation depth without any clinical doubts. The MEP parameters at BIS level 40 ± 5, proportionally compared with the baseline, were latency 104% (97-110%) and the MEP amplitudes 84.5% (51-109%). CONCLUSION: Preliminary data predict that deeper sedation (BIS 40 ± 5) does not affect the surgical team's interpretation of MEP in youth patients. These results support that surgeon-directed MEP may be an alternative when neurophysiologists are unavailable.
590    __
$a NEINDEXOVÁNO
655    _2
$a časopisecké články $7 D016428
700    1_
$a Kosinová, Martina $u Department of Simulation Medicine, Faculty of Medicine, Masaryk University, Brno, Czechia $u Department of Pediatric Anesthesiology and Intensive Care Medicine, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia
700    1_
$a Prokopová, Tereza $u Department of Anesthesiology and Intensive Care Medicine, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia $u Department of Simulation Medicine, Faculty of Medicine, Masaryk University, Brno, Czechia
700    1_
$a Zelinková, Hana $u Institute of Biostatistics and Analyses, Faculty of Medicine, Brno, Czechia
700    1_
$a Hudáček, Kamil $u Department of Anesthesiology and Intensive Care Medicine, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia
700    1_
$a Repko, Martin $u Department of Orthopedic Surgery, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia
700    1_
$a Gál, Roman $u Department of Anesthesiology and Intensive Care Medicine, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia
700    1_
$a Štourač, Petr $u Department of Simulation Medicine, Faculty of Medicine, Masaryk University, Brno, Czechia $u Department of Pediatric Anesthesiology and Intensive Care Medicine, University Hospital Brno and Faculty of Medicine, Masaryk University, Brno, Czechia
773    0_
$w MED00188756 $t Frontiers in medicine $x 2296-858X $g Roč. 11 (20241029), s. 1471450
856    41
$u https://pubmed.ncbi.nlm.nih.gov/39534220 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20250117 $b ABA008
991    __
$a 20250123101900 $b ABA008
999    __
$a ok $b bmc $g 2254523 $s 1238266
BAS    __
$a 3
BAS    __
$a PreBMC-PubMed-not-MEDLINE
BMC    __
$a 2024 $b 11 $c - $d 1471450 $e 20241029 $i 2296-858X $m Frontiers in medicine $n Front Med (Lausanne) $x MED00188756
LZP    __
$a Pubmed-20250117

Find record

Citation metrics

Archiving options