-
Je něco špatně v tomto záznamu ?
Associations between respiratory pathogens and lung function in primary ciliary dyskinesia: cross-sectional analysis from the PROVALF-PCD cohort
B. Rubbo, A. Kant, K. Zhang, A. Allegorico, S. Basilicata, M. Boon, M. Borrelli, C. Calogero, SB. Carr, M. Carroll, C. Constant, S. Castillo Corullón, H. Corvol, R. Cutrera, S. Dillenhöfer, N. Emiralioglu, E. Eralp, S. Eryilmaz Polat, L. Gardner,...
Status neindexováno Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články
NLK
Directory of Open Access Journals
od 2015
PubMed Central
od 2015
Europe PubMed Central
od 2015
Open Access Digital Library
od 2015-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2015
- Publikační typ
- časopisecké články MeSH
INTRODUCTION: Respiratory pathogens are frequently isolated from airway samples in primary ciliary dyskinesia (PCD) patients. Few studies have investigated associations between these pathogens and lung function, with current management based on evidence from cystic fibrosis. We investigated the association between commonly isolated respiratory pathogens and lung function in PCD patients. METHODS: Using a cross-sectional design, we prospectively collected clinical and concurrent microbiology data from 408 participants with probable or confirmed PCD, aged ≥5 years, from 12 countries. We used Global Lung Function Initiative 2012 references to calculate forced expiratory volume in 1 s (FEV1) z-scores. For 351 patients (86%) with complete data, we assessed the association of the four most frequently isolated pathogens with lung function by fitting multilevel linear models with country as random intercept, adjusted for age at diagnosis, age at lung function, use of antibiotic prophylaxis and body mass index z-scores. RESULTS: Individuals with Pseudomonas aeruginosa growth in culture had significantly lower FEV1 z-scores (β= -0.87, 95% CI -1.40- -0.34), adjusted for presence of Haemophilus influenzae, methicillin-sensitive Staphylococcus aureus and Streptococcus pneumoniae, and for covariates. When stratified by age, associations remained strong for adults but not for children. Results were similar when ciliary defects by transmission electron microscopy were included in the models and when restricting analysis to only confirmed PCD cases. CONCLUSIONS: We found that P. aeruginosa was associated with worse lung function in individuals with PCD, particularly adults. These findings suggest that it is prudent to aim for P. aeruginosa eradication in the first instance, and to treat exacerbations promptly in colonised patients.
Azienda Ospedaliero Universitaria Ospedale Pediatrico Meyer Florence Italy
Children's Hospital and Research Institute Marienhospital Wesel Wesel Germany
Clinical and Experimental Sciences University of Southampton Faculty of Medicine Southampton UK
Department of General Pediatrics University Hospital Muenster Muenster Germany
Department of Pediatric Pulmonology Hacettepe University Faculty of Medicine Ankara Turkey
Department of Pediatric Pulmonology Marmara Universitesi Istanbul Turkey
Department of Pediatrics Division of Pediatric Pulmonology Ankara City Hospital Ankara Turkey
Department of Pediatrics University Hospital Leuven Leuven Belgium
Department of Respiratory Diseases University Hospitals Leuven Leuven Belgium
Hospital Vall d'Hebron Neumología Infantil Barcelona Spain
Institute of Social and Preventive Medicine University of Bern Bern Switzerland
Medical School University of Cyprus Nicosia Cyprus
Royal Children's Hospital Respiratory Medicine Melbourne Australia
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc25002453
- 003
- CZ-PrNML
- 005
- 20250123101914.0
- 007
- ta
- 008
- 250117s2024 enk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1183/23120541.00253-2024 $2 doi
- 035 __
- $a (PubMed)39351386
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a enk
- 100 1_
- $a Rubbo, Bruna $u Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Southampton, UK $u Primary Ciliary Dyskinesia Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK $1 https://orcid.org/0000000216298601
- 245 10
- $a Associations between respiratory pathogens and lung function in primary ciliary dyskinesia: cross-sectional analysis from the PROVALF-PCD cohort / $c B. Rubbo, A. Kant, K. Zhang, A. Allegorico, S. Basilicata, M. Boon, M. Borrelli, C. Calogero, SB. Carr, M. Carroll, C. Constant, S. Castillo Corullón, H. Corvol, R. Cutrera, S. Dillenhöfer, N. Emiralioglu, E. Eralp, S. Eryilmaz Polat, L. Gardner, Y. Gokdemir, A. Harris, C. Hogg, B. Karadag, H. Kobbernagel, C. Koerner-Rettberg, P. Kouis, N. Lorent, M. Marcou, JK. Mathin, V. Martinu, A. Moreno-Galdó, L. Morgan, KG. Nielsen, H. Omran, U. Ozcelik, P. Pohunek, J. Raidt, P. Robinson, S. Rovira-Amigo, F. Santamaria, A. Schlegtendal, A. Tamalet, G. Thouvenin, N. Ullmann, W. Walker, P. Yiallouros, CE. Kuehni, P. Latzin, N. Beydon, JS. Lucas
- 520 9_
- $a INTRODUCTION: Respiratory pathogens are frequently isolated from airway samples in primary ciliary dyskinesia (PCD) patients. Few studies have investigated associations between these pathogens and lung function, with current management based on evidence from cystic fibrosis. We investigated the association between commonly isolated respiratory pathogens and lung function in PCD patients. METHODS: Using a cross-sectional design, we prospectively collected clinical and concurrent microbiology data from 408 participants with probable or confirmed PCD, aged ≥5 years, from 12 countries. We used Global Lung Function Initiative 2012 references to calculate forced expiratory volume in 1 s (FEV1) z-scores. For 351 patients (86%) with complete data, we assessed the association of the four most frequently isolated pathogens with lung function by fitting multilevel linear models with country as random intercept, adjusted for age at diagnosis, age at lung function, use of antibiotic prophylaxis and body mass index z-scores. RESULTS: Individuals with Pseudomonas aeruginosa growth in culture had significantly lower FEV1 z-scores (β= -0.87, 95% CI -1.40- -0.34), adjusted for presence of Haemophilus influenzae, methicillin-sensitive Staphylococcus aureus and Streptococcus pneumoniae, and for covariates. When stratified by age, associations remained strong for adults but not for children. Results were similar when ciliary defects by transmission electron microscopy were included in the models and when restricting analysis to only confirmed PCD cases. CONCLUSIONS: We found that P. aeruginosa was associated with worse lung function in individuals with PCD, particularly adults. These findings suggest that it is prudent to aim for P. aeruginosa eradication in the first instance, and to treat exacerbations promptly in colonised patients.
- 590 __
- $a NEINDEXOVÁNO
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Kant, Avni $u Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Southampton, UK $u Primary Ciliary Dyskinesia Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK
- 700 1_
- $a Zhang, Kewei $u Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Southampton, UK $u Primary Ciliary Dyskinesia Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK
- 700 1_
- $a Allegorico, Annalisa $u Respiratory and Cystic Fibrosis Unit, Academic Pediatric Department, Bambino Gesù Children Hospital, IRCCS, Rome, Italy
- 700 1_
- $a Basilicata, Simona $u Department of Translational Medical Sciences, Pediatric Pulmonology, Federico II University, Naples, Italy
- 700 1_
- $a Boon, Mieke $u Department of Pediatrics, University Hospital Leuven, Leuven, Belgium
- 700 1_
- $a Borrelli, Melissa $u Department of Translational Medical Sciences, Pediatric Pulmonology, Federico II University, Naples, Italy
- 700 1_
- $a Calogero, Claudia $u Azienda Ospedaliero Universitaria Ospedale Pediatrico Meyer, Florence, Italy
- 700 1_
- $a Carr, Siobhán B $u Royal Brompton and Harefield NHS Foundation Trust, Department of Paediatrics, Primary Ciliary Dyskinesia Centre, London, UK $1 https://orcid.org/0000000305802478
- 700 1_
- $a Carroll, Mary $u Primary Ciliary Dyskinesia Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK
- 700 1_
- $a Constant, Carolina $u Department of Pediatrics, Hospital de Santa Maria, Centro Hospitalar Universitário Lisboa Norte and Faculty of Medicine, University of Lisbon, Lisbon, Portugal $1 https://orcid.org/0000000265961596
- 700 1_
- $a Castillo Corullón, Silvia $u FE Pediatría y Neumología Infantil, Unidad de Neumología Infantil y Fibrosis Quística, Hospital Clínico de Valencia, Valencia, Spain $1 https://orcid.org/0000000201212676
- 700 1_
- $a Corvol, Harriet $u AP-HP, Sorbonne Université, Unité d'Exploration Fonctionnelle Respiratoire, Hôpital Armand-Trousseau, and Sorbonne Université, INSERM U938, Paris, France $1 https://orcid.org/0000000270267523
- 700 1_
- $a Cutrera, Renato $u Respiratory and Cystic Fibrosis Unit, Academic Pediatric Department, Bambino Gesù Children Hospital, IRCCS, Rome, Italy $1 https://orcid.org/0000000177115672
- 700 1_
- $a Dillenhöfer, Stefanie $u Department of Paediatric Pulmonology, University Children's Hospital, Ruhr University Bochum, Katholisches Klinikum Bochum, Bochum, Germany $u Children's Hospital and Research Institute, Marienhospital Wesel, Wesel, Germany
- 700 1_
- $a Emiralioglu, Nagehan $u Department of Pediatric Pulmonology, Hacettepe University Faculty of Medicine, Ankara, Turkey $1 https://orcid.org/0000000214058401
- 700 1_
- $a Eralp, Ela $u Department of Pediatric Pulmonology, Marmara Universitesi, Istanbul, Turkey
- 700 1_
- $a Eryilmaz Polat, Sanem $u Department of Pediatrics, Division of Pediatric Pulmonology, Ankara City Hospital, Ankara, Turkey
- 700 1_
- $a Gardner, Laura $u Royal Brompton and Harefield NHS Foundation Trust, Department of Paediatrics, Primary Ciliary Dyskinesia Centre, London, UK
- 700 1_
- $a Gokdemir, Yasemin $u Department of Pediatric Pulmonology, Marmara Universitesi, Istanbul, Turkey
- 700 1_
- $a Harris, Amanda $u Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Southampton, UK $u Primary Ciliary Dyskinesia Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK $1 https://orcid.org/0000000269537370
- 700 1_
- $a Hogg, Claire $u Royal Brompton and Harefield NHS Foundation Trust, Department of Paediatrics, Primary Ciliary Dyskinesia Centre, London, UK
- 700 1_
- $a Karadag, Bulent $u Department of Pediatric Pulmonology, Marmara Universitesi, Istanbul, Turkey $1 https://orcid.org/0000000306058871
- 700 1_
- $a Kobbernagel, Helene $u Danish PCD Centre, Danish Paediatric Pulmonary Service, Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark $u Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
- 700 1_
- $a Koerner-Rettberg, Cordula $u Department of Paediatric Pulmonology, University Children's Hospital, Ruhr University Bochum, Katholisches Klinikum Bochum, Bochum, Germany $u Children's Hospital and Research Institute, Marienhospital Wesel, Wesel, Germany
- 700 1_
- $a Kouis, Panayiotis $u Medical School, University of Cyprus, Nicosia, Cyprus
- 700 1_
- $a Lorent, Natalie $u Department of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium $u Department of CHROMETA, Laboratory for Respiratory Diseases and Thoracic Surgery, KU Leuven, Leuven, Belgium $1 https://orcid.org/0000000226535885
- 700 1_
- $a Marcou, Markella $u Medical School, University of Cyprus, Nicosia, Cyprus
- 700 1_
- $a Mathin, June K $u Danish PCD Centre, Danish Paediatric Pulmonary Service, Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark $u Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark $1 https://orcid.org/0000000244203091
- 700 1_
- $a Martinu, Vendula $u Department of Paediatrics, Charles University, 2nd Faculty of Medicine, University Hospital in Motol, Prague, Czech Republic
- 700 1_
- $a Moreno-Galdó, Antonio $u Hospital Vall d'Hebron, Neumología Infantil, Barcelona, Spain
- 700 1_
- $a Morgan, Lucy $u Concord Hospital, Concord Clinical School, University of Sydney, Department of Respiratory Medicine, Sydney, Australia $1 https://orcid.org/0000000163891953
- 700 1_
- $a Nielsen, Kim G $u Danish PCD Centre, Danish Paediatric Pulmonary Service, Department of Paediatrics and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark $u Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
- 700 1_
- $a Omran, Heymut $u Department of General Pediatrics, University Hospital Muenster, Muenster, Germany $1 https://orcid.org/0000000302826765
- 700 1_
- $a Ozcelik, Ugur $u Department of Pediatric Pulmonology, Hacettepe University Faculty of Medicine, Ankara, Turkey
- 700 1_
- $a Pohunek, Petr $u Department of Paediatrics, Charles University, 2nd Faculty of Medicine, University Hospital in Motol, Prague, Czech Republic $1 https://orcid.org/0000000345572515
- 700 1_
- $a Raidt, Johanna $u Department of General Pediatrics, University Hospital Muenster, Muenster, Germany
- 700 1_
- $a Robinson, Phil $u Royal Children's Hospital, Respiratory Medicine, Melbourne, Australia $u Faculty of Medicine Dentistry and Health Sciences, Paediatrics, University of Melbourne, Melbourne, Australia $1 https://orcid.org/0000000161299075
- 700 1_
- $a Rovira-Amigo, Sandra $u Hospital Vall d'Hebron, Neumología Infantil, Barcelona, Spain
- 700 1_
- $a Santamaria, Francesca $u Department of Translational Medical Sciences, Pediatric Pulmonology, Federico II University, Naples, Italy $1 https://orcid.org/0000000293757429
- 700 1_
- $a Schlegtendal, Anne $u Department of Paediatric Pulmonology, University Children's Hospital, Ruhr University Bochum, Katholisches Klinikum Bochum, Bochum, Germany $u Children's Hospital and Research Institute, Marienhospital Wesel, Wesel, Germany $1 https://orcid.org/0000000267373624
- 700 1_
- $a Tamalet, Aline $u AP-HP, Sorbonne Université, Unité d'Exploration Fonctionnelle Respiratoire, Hôpital Armand-Trousseau, and Sorbonne Université, INSERM U938, Paris, France
- 700 1_
- $a Thouvenin, Guillaume $u AP-HP, Sorbonne Université, Unité d'Exploration Fonctionnelle Respiratoire, Hôpital Armand-Trousseau, and Sorbonne Université, INSERM U938, Paris, France $1 https://orcid.org/0000000305285458
- 700 1_
- $a Ullmann, Nicola $u Respiratory and Cystic Fibrosis Unit, Academic Pediatric Department, Bambino Gesù Children Hospital, IRCCS, Rome, Italy
- 700 1_
- $a Walker, Woolf $u Primary Ciliary Dyskinesia Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK
- 700 1_
- $a Yiallouros, Panayiotis $u Medical School, University of Cyprus, Nicosia, Cyprus
- 700 1_
- $a Kuehni, Claudia E $u Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland $u Division of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, University Hospital, University of Bern, Bern, Switzerland $1 https://orcid.org/0000000189572002
- 700 1_
- $a Latzin, Philipp $u Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland $u Division of Paediatric Respiratory Medicine and Allergology, Department of Paediatrics, Inselspital, University Hospital, University of Bern, Bern, Switzerland $1 https://orcid.org/0000000252391571
- 700 1_
- $a Beydon, Nicole $u AP-HP, Sorbonne Université, Unité d'Exploration Fonctionnelle Respiratoire, Hôpital Armand-Trousseau, and Sorbonne Université, INSERM U938, Paris, France $1 https://orcid.org/000000026417382X
- 700 1_
- $a Lucas, Jane S $u Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Southampton, UK $u Primary Ciliary Dyskinesia Centre, University Hospital Southampton NHS Foundation Trust, Southampton, UK $1 https://orcid.org/0000000187019975
- 773 0_
- $w MED00198703 $t ERJ open research $x 2312-0541 $g Roč. 10, č. 5 (2024)
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/39351386 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y - $z 0
- 990 __
- $a 20250117 $b ABA008
- 991 __
- $a 20250123101908 $b ABA008
- 999 __
- $a ok $b bmc $g 2254583 $s 1238456
- BAS __
- $a 3
- BAS __
- $a PreBMC-PubMed-not-MEDLINE
- BMC __
- $a 2024 $b 10 $c 5 $e 20240930 $i 2312-0541 $m ERJ open research $n ERJ Open Res $x MED00198703
- LZP __
- $a Pubmed-20250117
