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Role of Alveolar-Arterial Difference in Estimation of Extravascular Lung Water in COVID-19-Related ARDS
M. Kutej, J. Sagan, T. Ekrtova, H. Strakova, M. Buzga, M. Burda, J. Maca
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, pozorovací studie
PubMed
39043425
DOI
10.4187/respcare.11804
Knihovny.cz E-zdroje
- MeSH
- COVID-19 * komplikace patofyziologie MeSH
- dospělí MeSH
- extravaskulární plicní voda * metabolismus MeSH
- kyslík * metabolismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- plicní alveoly * metabolismus patofyziologie MeSH
- plicní edém etiologie patofyziologie MeSH
- prospektivní studie MeSH
- senioři MeSH
- syndrom dechové tísně * patofyziologie etiologie MeSH
- výměna plynů v plicích MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- pozorovací studie MeSH
- Geografické názvy
- Česká republika MeSH
BACKGROUND: The dominant feature of COVID-19-associated ARDS is gas exchange impairment. Extravascular lung water index is a surrogate for lung edema and reflects the level of alveolocapillary disruption. The primary aim was the prediction of extravascular lung water index by the alveolar-arterial oxygen difference. The secondary aims were in determining the relationship between the extravascular lung water index and other oxygenation parameters, the [Formula: see text], end-tidal oxygen concentration, pulmonary oxygen gradient ([Formula: see text] minus end-tidal oxygen concentration), and [Formula: see text]. METHODS: This observational prospective single-center study was performed at the Department of Anaesthesiology and Intensive Care, The University Hospital in Ostrava, The Czech Republic, during the COVID-19 pandemic, from March 20, 2020, until May 24, 2021. RESULTS: The relationship between the extravascular lung water index and alveolar-arterial oxygen difference showed only a mild-to-moderate correlation (r = 0.33, P < .001). Other extravascular lung water index correlations were as follows: [Formula: see text] (r = 0.33, P < .001), end-tidal oxygen concentration (r = 0.26, P = .0032), [Formula: see text] minus end-tidal oxygen concentration (r = 0.15, P = .0624), and [Formula: see text] (r = -0.15, P = .01). CONCLUSIONS: The alveolar-arterial oxygen difference does not reliably correlate with the extravascular lung water index and the degree of lung edema in COVID-19-associated ARDS.
Department of Infectious Diseases University Hospital Ostrava Ostrava Czech Republic
Department of Surgical Studies University Hospital Ostrava Ostrava Czech Republic
Citace poskytuje Crossref.org
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