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Je něco špatně v tomto záznamu ?
MicroRNAs and other biomarkers of atrial fibrillation in ischemic stroke patients
P. Janský, V. Kaplan, T. Šrámková, F. Kolman, P. Kloudová, K. Benešová, A. Olšerová, P. Kešnerová, H. Magerová, V. Šulc, H. Halmová, S. Kmetonyová, J. Paulasová-Schwabová, I. Šarbochová, V. Maťoška, A. Tomek
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, pozorovací studie
Grantová podpora
project No. 618217
Charles University Grant Agency (GA UK),
NLK
Directory of Open Access Journals
od 2014
PubMed Central
od 2013 do Před 2 týdny
Europe PubMed Central
od 2013
Open Access Digital Library
od 2013-01-01
Open Access Digital Library
od 2014-01-01
- MeSH
- biologické markery * krev MeSH
- C-reaktivní protein analýza MeSH
- fibrilace síní * krev diagnóza genetika MeSH
- ischemická cévní mozková příhoda * krev diagnóza MeSH
- lidé středního věku MeSH
- lidé MeSH
- mikro RNA * krev MeSH
- natriuretický peptid typu B krev MeSH
- peptidové fragmenty krev MeSH
- prospektivní studie MeSH
- ROC křivka MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- studie případů a kontrol MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- pozorovací studie MeSH
This study aimed to evaluate the ability of selected microRNAs as biomarkers of atrial fibrillation (AF) in ischemic stroke patients in comparison with other established biochemical biomarkers. A prospective case-control study of consecutive ischemic stroke patients with AF admitted to a comprehensive stroke center was conducted. The control group consisted of patients with ischemic stroke with no AF detected on prolonged (at least 3 weeks) Holter ECG monitoring. As potential biomarkers of AF, we analyzed the plasma levels of microRNAs (miR-21, miR-29b, miR-133b, miR-142-5p, miR-150, miR-499, and miR-223-3p) and 13 biochemical biomarkers at admission. The predictive accuracy of biomarkers was assessed by calculating the area under the receiver operating characteristic curve. The data of 117 patients were analyzed (61 with AF, 56 with no AF, 46% men, median age 73 years, median National Institutes of Health Stroke Scale 6). Biochemical biomarkers (N-terminal pro-B-type natriuretic peptide [NT-proBNP], high-sensitivity cardiac troponin I, fibrinogen, C-reactive protein, eGFR, and total triglycerides) were significantly associated with AF. NT-proBNP had the best diagnostic performance for AF with area under the receiver operating characteristic curve 0.92 (95%, CI 0.86-0.98); a cutoff value of >528 ng/L had a sensitivity of 79% and a specificity of 97%. None of the other biomarkers, including microRNAs, was associated with AF. Conventional biochemical biomarkers (NT-proBNP, high-sensitivity cardiac troponin I, fibrinogen, C-reactive protein, eGFR, and triglycerides), but not microRNAs (miR-21, miR-29b, miR-133b, miR-142-5p, miR-150, miR-499, and miR-223-3p) were significantly associated with AF in our ischemic stroke cohort.
Citace poskytuje Crossref.org
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