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Concordant inter-laboratory derived concentrations of ceramides in human plasma reference materials via authentic standards
F. Torta, N. Hoffmann, B. Burla, I. Alecu, M. Arita, T. Bamba, SAL. Bennett, J. Bertrand-Michel, B. Brügger, MP. Cala, D. Camacho-Muñoz, A. Checa, M. Chen, M. Chocholoušková, M. Cinel, E. Chu-Van, B. Colsch, C. Coman, L. Connell, BC. Sousa, AM....
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články
Grantová podpora
PG/2019/34923
British Heart Foundation - United Kingdom
NLK
Directory of Open Access Journals
od 2015
Free Medical Journals
od 2010
Nature Open Access
od 2010-12-01
PubMed Central
od 2012
Europe PubMed Central
od 2012
ProQuest Central
od 2010-01-01
Open Access Digital Library
od 2015-01-01
Open Access Digital Library
od 2015-01-01
Medline Complete (EBSCOhost)
od 2012-11-01
Health & Medicine (ProQuest)
od 2010-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2010
- MeSH
- ceramidy * krev MeSH
- hmotnostní spektrometrie metody MeSH
- kalibrace MeSH
- laboratoře * normy MeSH
- lidé MeSH
- lipidomika metody MeSH
- referenční standardy * MeSH
- reprodukovatelnost výsledků MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
In this community effort, we compare measurements between 34 laboratories from 19 countries, utilizing mixtures of labelled authentic synthetic standards, to quantify by mass spectrometry four clinically used ceramide species in the NIST (National Institute of Standards and Technology) human blood plasma Standard Reference Material (SRM) 1950, as well as a set of candidate plasma reference materials (RM 8231). Participants either utilized a provided validated method and/or their method of choice. Mean concentration values, and intra- and inter-laboratory coefficients of variation (CV) were calculated using single-point and multi-point calibrations, respectively. These results are the most precise (intra-laboratory CVs ≤ 4.2%) and concordant (inter-laboratory CVs < 14%) community-derived absolute concentration values reported to date for four clinically used ceramides in the commonly analyzed SRM 1950. We demonstrate that calibration using authentic labelled standards dramatically reduces data variability. Furthermore, we show how the use of shared RM can correct systematic quantitative biases and help in harmonizing lipidomics. Collectively, the results from the present study provide a significant knowledge base for translation of lipidomic technologies to future clinical applications that might require the determination of reference intervals (RIs) in various human populations or might need to estimate reference change values (RCV), when analytical variability is a key factor for recall during multiple testing of individuals.
Avanti Polar Lipids Alabaster AL USA
Babraham Institute Babraham Research Campus Cambridge MA CB22 3AT USA
Baker Heart and Diabetes Institute Melbourne VIC 3004 Australia
Center for Biotechnology and Biomedicine University of Leipzig 04013 Leipzig Germany
Chemical Science Division National Institute of Standards and Technology Charleston SC 29412 USA
Chemical Science Division National Institute of Standards and Technology Gaithersburg MD 20899 USA
College of Health and Life Sciences Hamad Bin Khalifa University Doha Qatar
Core Facility Mass Spectrometry Medical University of Graz 8010 Graz Austria
Department of Analytical Chemistry University of Vienna Vienna Austria
Department of Chemistry University of Turku Turku Finland
Department of Chemistry Yonsei University Seoul 03722 South Korea
Department of Pathology and Laboratory Medicine University of British Columbia Vancouver BC Canada
Department of Respiratory Medicine and Allergy Karolinska University Hospital Stockholm Sweden
Faculty of Pharmaceutical Sciences University of Iceland Reykjavik Iceland
Graduate School of Medical Life Science Yokohama City University Yokohama Japan
Heidelberg University Biochemistry Center Im Neuenheimer Feld 328 69120 Heidelberg Germany
Institute for Bio and Geosciences Forschungszentrum Jülich GmbH 52428 Jülich Germany
Institute for Stem Cell Science and Regenerative Medicine 560065 Bangalore India
Institute of Clinical Chemistry University Zurich 8952 Schlieren Switzerland
Lee Kong Chian School of Medicine Nanyang Technological University Singapore 636921 Singapore
LipidALL Technologies Changzhou 213000 Jiangshu China
Lipidomics Consulting Ltd Espoo Finland
Lydia Becker Institute of Immunology and Inflammation
MetaboHUBMetaToul Facility I2MC U1297 Inserm Toulouse France
Metabolomics Core Facility MetCore Universidad de los Andes Bogotá 111711 Colombia
Metabolomics Platform Faculty of Biology and Medicine University of Lausanne Lausanne Switzerland
RIKEN Center for Integrative Medical Sciences Yokohama Japan
RIKEN Center for Sustainable Resource Science Yokohama Japan
School of Medical Sciences Faculty of Medicine and Health Örebro University 702 81 Örebro Sweden
St Paul's Hospital Department of Pathology and Laboratory Medicine Vancouver BC Canada
Turku Bioscience Centre University of Turku and Åbo Akademi University 20520 Turku Finland
Citace poskytuje Crossref.org
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- $a PG/2019/34923 $p British Heart Foundation $2 United Kingdom
- LZP __
- $a Pubmed-20250121
