-
Something wrong with this record ?
Association between polychlorinated biphenyls and circulatory immune markers: results from NHANES 1999-2004
M. Yuzhu, L. Wei, L. Ying, C. Yong, H. Kesheng
Language English Country Czech Republic
Document type Journal Article
Digital library NLK
Source
NLK
Free Medical Journals
from 2004
ProQuest Central
from 2009-03-01 to 6 months ago
Medline Complete (EBSCOhost)
from 2006-03-01 to 6 months ago
Nursing & Allied Health Database (ProQuest)
from 2009-03-01 to 6 months ago
Health & Medicine (ProQuest)
from 2009-03-01 to 6 months ago
Public Health Database (ProQuest)
from 2009-03-01 to 6 months ago
ROAD: Directory of Open Access Scholarly Resources
from 1993
PubMed
39903597
DOI
10.21101/cejph.a8056
Knihovny.cz E-resources
- MeSH
- Biomarkers * blood MeSH
- Adult MeSH
- Environmental Pollutants * blood MeSH
- Middle Aged MeSH
- Humans MeSH
- Polychlorinated Biphenyls * blood toxicity MeSH
- Aged MeSH
- Environmental Exposure adverse effects analysis MeSH
- Nutrition Surveys * MeSH
- Inflammation blood chemically induced immunology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
OBJECTIVES: Polychlorinated biphenyls (PCBs), a family of persistent toxic and organic environmental pollutants, were associated with multiple organ damages in humans once accumulating. However, association between PCBs exposure and circulatory immune markers were not clear. METHODS: Data was collected from participants enrolled in the National Health and Nutrition Examination Survey in 1999-2004. PCBs were categorized by latent class analysis (LCA). Weighted quantile sum (WQS) regression was used to investigate effects of PCBs exposure on circulatory immune markers including leukocyte counts, monocyte-lymphocyte ratio (MLR), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII). RESULTS: There were 3,109 participants included in the final analysis with blood PCBs levels presented as 3 classes. The high PCBs group had a higher rate of comorbidities. Leukocyte, lymphocyte and neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and system immune-inflammation index (SII) were significantly lower in the high PCBs group than in the low PCBs group (all p-values < 0.05). After adjusting for covariant variables, the low PCBs group was positively associated with SII (p = 0.021) and NLR (p = 0.006) in multivariate regression. Significantly negative correlations between PCBs classification and SII (β = -14.513, p = 0.047), and NLR (β = -0.035, p = 0.017) were found in WQS models. LBX028LA showed the most significant contribution in the associations between PCBs and SII, and LBX128LA contributed most significantly to associations with NLR. CONCLUSION: Our study adds novel evidence that exposures to PCBs may be adversely associated with the circulatory immune markers, indicating the potential toxic effect of PCBs on the human immune system.
Department of Cardiac Surgery YueBei People's Hospital Shaoguan City China
Department of Endocrinology Armed Police Corps Hospital of Guangdong Province Guangzhou China
Department of Lab Medicine Armed Police Corps Hospital of Guangdong Province Guangzhou China
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc25005477
- 003
- CZ-PrNML
- 005
- 20250521143028.0
- 007
- ta
- 008
- 250213s2024 xr d f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.21101/cejph.a8056 $2 doi
- 035 __
- $a (PubMed)39903597
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xr
- 100 1_
- $a Yuzhu, Ma $u Department of Clinical Laboratory, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, Suzhou, China
- 245 10
- $a Association between polychlorinated biphenyls and circulatory immune markers: results from NHANES 1999-2004 / $c M. Yuzhu, L. Wei, L. Ying, C. Yong, H. Kesheng
- 520 9_
- $a OBJECTIVES: Polychlorinated biphenyls (PCBs), a family of persistent toxic and organic environmental pollutants, were associated with multiple organ damages in humans once accumulating. However, association between PCBs exposure and circulatory immune markers were not clear. METHODS: Data was collected from participants enrolled in the National Health and Nutrition Examination Survey in 1999-2004. PCBs were categorized by latent class analysis (LCA). Weighted quantile sum (WQS) regression was used to investigate effects of PCBs exposure on circulatory immune markers including leukocyte counts, monocyte-lymphocyte ratio (MLR), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII). RESULTS: There were 3,109 participants included in the final analysis with blood PCBs levels presented as 3 classes. The high PCBs group had a higher rate of comorbidities. Leukocyte, lymphocyte and neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and system immune-inflammation index (SII) were significantly lower in the high PCBs group than in the low PCBs group (all p-values < 0.05). After adjusting for covariant variables, the low PCBs group was positively associated with SII (p = 0.021) and NLR (p = 0.006) in multivariate regression. Significantly negative correlations between PCBs classification and SII (β = -14.513, p = 0.047), and NLR (β = -0.035, p = 0.017) were found in WQS models. LBX028LA showed the most significant contribution in the associations between PCBs and SII, and LBX128LA contributed most significantly to associations with NLR. CONCLUSION: Our study adds novel evidence that exposures to PCBs may be adversely associated with the circulatory immune markers, indicating the potential toxic effect of PCBs on the human immune system.
- 650 _2
- $a lidé $7 D006801
- 650 12
- $a polychlorované bifenyly $x krev $x toxicita $7 D011078
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 12
- $a výživa - přehledy $7 D009749
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 12
- $a biologické markery $x krev $7 D015415
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a dospělí $7 D000328
- 650 12
- $a látky znečišťující životní prostředí $x krev $7 D004785
- 650 _2
- $a vystavení vlivu životního prostředí $x škodlivé účinky $x analýza $7 D004781
- 650 _2
- $a zánět $x krev $x chemicky indukované $x imunologie $7 D007249
- 650 _2
- $a senioři $7 D000368
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Wei, Li $u Department of Endocrinology, Armed Police Corps Hospital of Guangdong Province, Guangzhou, China
- 700 1_
- $a Ying, Liu $u Department of Cardiac Surgery, YueBei People's Hospital, Shaoguan City, China
- 700 1_
- $a Yong, Chen $u Department of Cardiac Surgery, YueBei People's Hospital, Shaoguan City, China
- 700 1_
- $a Kesheng, Hu $u Department of Lab Medicine, Armed Police Corps Hospital of Guangdong Province, Guangzhou, China
- 773 0_
- $w MED00001083 $t Central European journal of public health $x 1210-7778 $g Roč. 32, č. 4 (2024), s. 263-272
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/39903597 $y Pubmed
- 910 __
- $a ABA008 $b B 1829 $c 562 $y p $z 0
- 990 __
- $a 20250213 $b ABA008
- 991 __
- $a 20250521143026 $b ABA008
- 999 __
- $a ok $b bmc $g 2324840 $s 1242497
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2024 $b 32 $c 4 $d 263-272 $e - $i 1210-7778 $m Central European journal of public health $n Cent Eur J Public Health $x MED00001083
- LZP __
- $b NLK116 $a Pubmed-20250213
