Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Long-Term Adverse Effects of Perinatal Hypoxia on the Adult Pulmonary Circulation Vary Between Males and Females in a Murine Model

AC. Peyter, V. Muehlethaler, JF. Tolsa

. 2024 ; 73 (Suppl. 2) : S541-S556. [pub] 20241129

Status minimální Jazyk angličtina Země Česko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc25005527

Adverse events during the perinatal period are associated with an increased risk to develop cardiometabolic diseases later in life. We established a murine model to study long-term effects of perinatal hypoxia (PH) on the pulmonary circulation. We previously demonstrated that PH led to an impaired regulation of pulmonary vascular tone in adulthood, linked to alterations in K+ channels in males and in the nitric oxide (NO)/cyclic guanosine monophosphate pathway in females. Moreover, simultaneous administration of inhaled NO (iNO) during PH exposure prevented adverse effects of PH on adult pulmonary vasculature in females. The present study showed that PH induced a significant increase in right ventricular pressure in males and females, and an enhanced sensitivity to acute hypoxia in females. PH significantly reduced acetylcholine-induced relaxation in pulmonary artery, to a greater extent in females than in males. PH led to right ventricular hypertrophy in adulthood, appearing earlier in males than in females. Morphometric measurements showed a significant increase in the number of 25-75-μm pulmonary vessels in male lungs following PH, probably resulting in increased pulmonary vascular resistance. The effects of prolonged hypoxia in adulthood differed between males and females. Perinatal iNO during PH prevented PH-induced alterations in the cardiopulmonary system, whereas perinatal iNO alone could have some adverse effects. Therefore, PH led to long-lasting alterations in the regulation of adult pulmonary circulation, which vary between males and females. In males, the increased pulmonary vascular resistance was associated with morphological changes besides functional alterations, whereas females showed an important pulmonary vascular dysfunction. Keywords: Perinatal hypoxia, Pulmonary circulation, Endothelium-dependent relaxation, Phosphodiesterases, Sex differences.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc25005527
003      
CZ-PrNML
005      
20250312151249.0
007      
ta
008      
250213s2024 xr f 000 0|eng||
009      
AR
024    7_
$a 10.33549/physiolres.935481 $2 doi
035    __
$a (PubMed)39589302
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Peyter, A-C $u Neonatal Res Lab, Dept Woman-Mother-Child, Lausanne Univ Hosp and Univ Lausanne, Lausanne, Switzerland. Anne-Christine.Peyter@chuv.ch
245    10
$a Long-Term Adverse Effects of Perinatal Hypoxia on the Adult Pulmonary Circulation Vary Between Males and Females in a Murine Model / $c AC. Peyter, V. Muehlethaler, JF. Tolsa
520    9_
$a Adverse events during the perinatal period are associated with an increased risk to develop cardiometabolic diseases later in life. We established a murine model to study long-term effects of perinatal hypoxia (PH) on the pulmonary circulation. We previously demonstrated that PH led to an impaired regulation of pulmonary vascular tone in adulthood, linked to alterations in K+ channels in males and in the nitric oxide (NO)/cyclic guanosine monophosphate pathway in females. Moreover, simultaneous administration of inhaled NO (iNO) during PH exposure prevented adverse effects of PH on adult pulmonary vasculature in females. The present study showed that PH induced a significant increase in right ventricular pressure in males and females, and an enhanced sensitivity to acute hypoxia in females. PH significantly reduced acetylcholine-induced relaxation in pulmonary artery, to a greater extent in females than in males. PH led to right ventricular hypertrophy in adulthood, appearing earlier in males than in females. Morphometric measurements showed a significant increase in the number of 25-75-μm pulmonary vessels in male lungs following PH, probably resulting in increased pulmonary vascular resistance. The effects of prolonged hypoxia in adulthood differed between males and females. Perinatal iNO during PH prevented PH-induced alterations in the cardiopulmonary system, whereas perinatal iNO alone could have some adverse effects. Therefore, PH led to long-lasting alterations in the regulation of adult pulmonary circulation, which vary between males and females. In males, the increased pulmonary vascular resistance was associated with morphological changes besides functional alterations, whereas females showed an important pulmonary vascular dysfunction. Keywords: Perinatal hypoxia, Pulmonary circulation, Endothelium-dependent relaxation, Phosphodiesterases, Sex differences.
650    _2
$a zvířata $7 D000818
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a mužské pohlaví $7 D008297
650    12
$a hypoxie $x patofyziologie $x metabolismus $7 D000860
650    12
$a plicní oběh $x fyziologie $7 D011652
650    _2
$a myši $7 D051379
650    _2
$a modely nemocí na zvířatech $7 D004195
650    _2
$a sexuální faktory $7 D012737
650    _2
$a těhotenství $7 D011247
650    _2
$a myši inbrední C57BL $7 D008810
650    _2
$a pohlavní dimorfismus $7 D012727
650    _2
$a oxid dusnatý $x metabolismus $7 D009569
650    _2
$a novorozená zvířata $7 D000831
650    _2
$a arteria pulmonalis $x metabolismus $x patofyziologie $x účinky léků $7 D011651
650    _2
$a cévní rezistence $x fyziologie $7 D014655
655    _2
$a časopisecké články $7 D016428
700    1_
$a Muehlethaler, V
700    1_
$a Tolsa, J-F
773    0_
$w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 73, Suppl. 2 (2024), s. S541-S556
856    41
$u https://pubmed.ncbi.nlm.nih.gov/39589302 $y Pubmed
910    __
$a ABA008 $b A 4120 $c 266 $y - $z 0
990    __
$a 20250213 $b ABA008
991    __
$a 20250312151256 $b ABA008
999    __
$a min $b bmc $g 2283563 $s 1242547
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2024 $b 73 $c Suppl. 2 $d S541-S556 $e 20241129 $i 1802-9973 $m Physiological research $n Physiol Res $x MED00003824
LZP    __
$a Pubmed-20250213

Najít záznam

Citační ukazatele

Nahrávání dat ...

Možnosti archivace

Nahrávání dat ...