• Je něco špatně v tomto záznamu ?

Quantitative magnetic resonance imaging parameters of lumbar paraspinal muscle impairment in myotonic dystrophy type 2 and their evolution with aging

V. Kokosova, P. Krkoska, D. Vlazna, M. Sladeckova, M. Dostal, M. Kerkovsky, T. Barusova, P. Ovesna, O. Parmova, K. Matulova, B. Adamova

. 2025 ; 16 (-) : 1525952. [pub] 20250219

Status neindexováno Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc25008393

INTRODUCTION: Muscle magnetic resonance imaging (MRI) is an emerging method in the diagnosis and monitoring of muscular dystrophies. This cross-sectional, comparative study aimed to evaluate quantitative MRI (qMRI) parameters of the lumbar paraspinal muscles (LPM) in myotonic dystrophy type 2 (DM2), to assess their relationship with functional examination, and to evaluate their evolution with aging. METHODS: The study enrolled 37 DM2 patients and 90 healthy volunteers (HV) who were matched based on physiological parameters to create 35 pairs. Utilizing a 6-point Dixon gradient echo sequence MRI, fat fraction (FF), total muscle volume, and functional muscle volume (FMV) of the LPM and psoas muscle (PS) were obtained. Using correlation coefficients and regression models, the relationship between MRI and the maximal isometric lumbar extensor muscle strength (MILEMS) and lumbar extensor muscle endurance (LEME), and their evolution with age, were assessed. RESULTS: LPM showed significantly higher FF in DM2 patients compared to HV (21.3% vs. 11.3%, p-value <0.001). FMV of LPM correlated significantly with MILEMS (ρ = 0.5, p- value = 0.001) and FF with LEME (ρ = -0.49, p- value = 0.002) in DM2. No significant differences in the rate of deterioration in functional and morphological parameters of the LPM with age were observed between the two groups. CONCLUSION: We demonstrated morphological correlates of lumbar extensor muscle dysfunction in DM2 patients. The qMRI parameters of LPM correlated with functional parameters but could not be used either as a reliable biomarker of lumbar extensor muscle impairment or as a biomarker of disease progression.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc25008393
003      
CZ-PrNML
005      
20250422095637.0
007      
ta
008      
250408e20250219sz f 000 0|eng||
009      
AR
024    7_
$a 10.3389/fneur.2025.1525952 $2 doi
035    __
$a (PubMed)40046670
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a sz
100    1_
$a Kokosova, Viktoria $u Department of Neurology, Centre for Neuromuscular Diseases (Associated National Centre in the ERN EURO-NMD), University Hospital Brno, Brno, Czechia $u Faculty of Medicine, Masaryk University, Brno, Czechia
245    10
$a Quantitative magnetic resonance imaging parameters of lumbar paraspinal muscle impairment in myotonic dystrophy type 2 and their evolution with aging / $c V. Kokosova, P. Krkoska, D. Vlazna, M. Sladeckova, M. Dostal, M. Kerkovsky, T. Barusova, P. Ovesna, O. Parmova, K. Matulova, B. Adamova
520    9_
$a INTRODUCTION: Muscle magnetic resonance imaging (MRI) is an emerging method in the diagnosis and monitoring of muscular dystrophies. This cross-sectional, comparative study aimed to evaluate quantitative MRI (qMRI) parameters of the lumbar paraspinal muscles (LPM) in myotonic dystrophy type 2 (DM2), to assess their relationship with functional examination, and to evaluate their evolution with aging. METHODS: The study enrolled 37 DM2 patients and 90 healthy volunteers (HV) who were matched based on physiological parameters to create 35 pairs. Utilizing a 6-point Dixon gradient echo sequence MRI, fat fraction (FF), total muscle volume, and functional muscle volume (FMV) of the LPM and psoas muscle (PS) were obtained. Using correlation coefficients and regression models, the relationship between MRI and the maximal isometric lumbar extensor muscle strength (MILEMS) and lumbar extensor muscle endurance (LEME), and their evolution with age, were assessed. RESULTS: LPM showed significantly higher FF in DM2 patients compared to HV (21.3% vs. 11.3%, p-value <0.001). FMV of LPM correlated significantly with MILEMS (ρ = 0.5, p- value = 0.001) and FF with LEME (ρ = -0.49, p- value = 0.002) in DM2. No significant differences in the rate of deterioration in functional and morphological parameters of the LPM with age were observed between the two groups. CONCLUSION: We demonstrated morphological correlates of lumbar extensor muscle dysfunction in DM2 patients. The qMRI parameters of LPM correlated with functional parameters but could not be used either as a reliable biomarker of lumbar extensor muscle impairment or as a biomarker of disease progression.
590    __
$a NEINDEXOVÁNO
655    _2
$a časopisecké články $7 D016428
700    1_
$a Krkoska, Peter $u Department of Neurology, Centre for Neuromuscular Diseases (Associated National Centre in the ERN EURO-NMD), University Hospital Brno, Brno, Czechia $u Faculty of Medicine, Masaryk University, Brno, Czechia
700    1_
$a Vlazna, Daniela $u Department of Neurology, Centre for Neuromuscular Diseases (Associated National Centre in the ERN EURO-NMD), University Hospital Brno, Brno, Czechia $u Faculty of Medicine, Masaryk University, Brno, Czechia $u Department of Rehabilitation, University Hospital Brno, Brno, Czechia
700    1_
$a Sladeckova, Michaela $u Department of Neurology, Centre for Neuromuscular Diseases (Associated National Centre in the ERN EURO-NMD), University Hospital Brno, Brno, Czechia $u Faculty of Medicine, Masaryk University, Brno, Czechia $u Department of Rehabilitation, University Hospital Brno, Brno, Czechia $u Department of Public Health, Faculty of Medicine, Masaryk University, Brno, Czechia
700    1_
$a Dostal, Marek $u Faculty of Medicine, Masaryk University, Brno, Czechia $u Department of Radiology and Nuclear Medicine, University Hospital Brno, Brno, Czechia
700    1_
$a Kerkovsky, Milos $u Faculty of Medicine, Masaryk University, Brno, Czechia $u Department of Radiology and Nuclear Medicine, University Hospital Brno, Brno, Czechia
700    1_
$a Barusova, Tamara $u Institute of Biostatistics and Analyses Ltd., Brno, Czechia
700    1_
$a Ovesna, Petra $u Institute of Biostatistics and Analyses Ltd., Brno, Czechia
700    1_
$a Parmova, Olesja $u Department of Neurology, Centre for Neuromuscular Diseases (Associated National Centre in the ERN EURO-NMD), University Hospital Brno, Brno, Czechia $u Faculty of Medicine, Masaryk University, Brno, Czechia
700    1_
$a Matulova, Katerina $u Faculty of Medicine, Masaryk University, Brno, Czechia
700    1_
$a Adamova, Blanka $u Department of Neurology, Centre for Neuromuscular Diseases (Associated National Centre in the ERN EURO-NMD), University Hospital Brno, Brno, Czechia $u Faculty of Medicine, Masaryk University, Brno, Czechia
773    0_
$w MED00174552 $t Frontiers in neurology $x 1664-2295 $g Roč. 16 (20250219), s. 1525952
856    41
$u https://pubmed.ncbi.nlm.nih.gov/40046670 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20250408 $b ABA008
991    __
$a 20250422095639 $b ABA008
999    __
$a ok $b bmc $g 2306363 $s 1245468
BAS    __
$a 3
BAS    __
$a PreBMC-PubMed-not-MEDLINE
BMC    __
$a 2025 $b 16 $c - $d 1525952 $e 20250219 $i 1664-2295 $m Frontiers in neurology $n Front Neurol $x MED00174552
LZP    __
$a Pubmed-20250408

Najít záznam

Citační ukazatele

Možnosti archivace