Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Sleep quality and the integrity of ascending reticular activating system - A multimodal MRI study

V. Kokošová, L. Vojtíšek, M. Baláž, S. Mangia, S. Michaeli, P. Filip

. 2024 ; 10 (22) : e40192. [pub] 20241107

Status not-indexed Language English Country England, Great Britain

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc25008823

Grant support
P41 EB027061 NIBIB NIH HHS - United States

Sleep is crucial for maintaining brain homeostasis and individuals with insufficient sleep are prone to more pronounced brain atrophy as compared to sufficiently sleeping peers. Moreover, sleep quality deteriorates with ageing and ageing is also associated with cerebral structural and functional changes, pointing to their mutual bidirectional interrelationship. This study aimed at determining whether sleep quality and age, separately, affect brain integrity and subsequently, whether sleep significantly modulates the effect of age on brain structural and functional integrity. 113 healthy volunteers underwent a multi-modal MRI imaging to extract information about the microstructure and function of major nodes of the ascending reticular activating system. Sleep quality was assessed by self-administered Pittsburgh's sleep quality index (PSQI) questionnaire. Subject were divided into good (global PSQI score <5) and poor (global PSQI score ≥5) sleep quality group. Whereas only borderline correlations were found between sleep quality and MRI metrics, age exhibited widespread correlations with both functional and microstructural MRI metrics. The latter effect was significantly modulated by sleep quality in ascending reticular activating system, hypothalamus, thalamus and also hippocampus in MRI metrics associated with iron load, cellularity and connectivity, mainly in the subgroup with poor sleep quality. Ergo, our results indicate sleep quality as a substantial contributor to both microstructural and functional brain changes in ageing and call for further research in this emerging topic.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc25008823
003      
CZ-PrNML
005      
20250429095220.0
007      
ta
008      
250408s2024 enkda f 000 0|eng||
009      
AR
024    7_
$a 10.1016/j.heliyon.2024.e40192 $2 doi
035    __
$a (PubMed)39748972
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Kokošová, Viktória $u First Department of Neurology, Faculty of Medicine, Masaryk University and University Hospital of St. Anne, Brno, Czech Republic $u Department of Neurology, Faculty of Medicine, Masaryk University and University Hospital Brno, Brno, Czech Republic $7 xx0331367
245    10
$a Sleep quality and the integrity of ascending reticular activating system - A multimodal MRI study / $c V. Kokošová, L. Vojtíšek, M. Baláž, S. Mangia, S. Michaeli, P. Filip
520    9_
$a Sleep is crucial for maintaining brain homeostasis and individuals with insufficient sleep are prone to more pronounced brain atrophy as compared to sufficiently sleeping peers. Moreover, sleep quality deteriorates with ageing and ageing is also associated with cerebral structural and functional changes, pointing to their mutual bidirectional interrelationship. This study aimed at determining whether sleep quality and age, separately, affect brain integrity and subsequently, whether sleep significantly modulates the effect of age on brain structural and functional integrity. 113 healthy volunteers underwent a multi-modal MRI imaging to extract information about the microstructure and function of major nodes of the ascending reticular activating system. Sleep quality was assessed by self-administered Pittsburgh's sleep quality index (PSQI) questionnaire. Subject were divided into good (global PSQI score <5) and poor (global PSQI score ≥5) sleep quality group. Whereas only borderline correlations were found between sleep quality and MRI metrics, age exhibited widespread correlations with both functional and microstructural MRI metrics. The latter effect was significantly modulated by sleep quality in ascending reticular activating system, hypothalamus, thalamus and also hippocampus in MRI metrics associated with iron load, cellularity and connectivity, mainly in the subgroup with poor sleep quality. Ergo, our results indicate sleep quality as a substantial contributor to both microstructural and functional brain changes in ageing and call for further research in this emerging topic.
590    __
$a NEINDEXOVÁNO
655    _2
$a časopisecké články $7 D016428
700    1_
$a Vojtíšek, Lubomír $u Central European Institute of Technology (CEITEC) Masaryk University, Neuroscience Centre, Brno, Czech Republic $7 xx0331412
700    1_
$a Baláž, Marek, $u First Department of Neurology, Faculty of Medicine, Masaryk University and University Hospital of St. Anne, Brno, Czech Republic $d 1976- $7 xx0100990
700    1_
$a Mangia, Silvia $u Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA
700    1_
$a Michaeli, Shalom $u Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA
700    1_
$a Filip, Pavel $u Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA $u Department of Neurology, Charles University, First Faculty of Medicine and General University Hospital, Prague, Czech Republic $u Department of Cybernetics, Czech Technical University in Prague, Prague, Czech Republic $7 xx0247515
773    0_
$w MED00190064 $t Heliyon $x 2405-8440 $g Roč. 10, č. 22 (2024), s. e40192
856    41
$u https://pubmed.ncbi.nlm.nih.gov/39748972 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20250408 $b ABA008
991    __
$a 20250429095216 $b ABA008
999    __
$a ok $b bmc $g 2306496 $s 1245898
BAS    __
$a 3
BAS    __
$a PreBMC-PubMed-not-MEDLINE
BMC    __
$a 2024 $b 10 $c 22 $d e40192 $e 20241107 $i 2405-8440 $m Heliyon $n Heliyon $x MED00190064
GRA    __
$a P41 EB027061 $p NIBIB NIH HHS $2 United States
LZP    __
$b NLK116 $a Pubmed-20250408

Find record

Citation metrics

Archiving options