-
Je něco špatně v tomto záznamu ?
Abnormal neuronal activity in the subthalamic nucleus contributes to dysarthria in patients with Parkinson's disease
Y. Diao, Z. Yin, B. Zhao, Y. Xu, Y. Jiang, Y. Yin, A. Yang, Y. Zhu, J. Hlavnicka, J. Zhang
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
- MeSH
- akční potenciály fyziologie MeSH
- dysartrie * etiologie patofyziologie MeSH
- hluboká mozková stimulace * metody MeSH
- lidé středního věku MeSH
- lidé MeSH
- neurony * fyziologie MeSH
- nucleus subthalamicus * patofyziologie MeSH
- Parkinsonova nemoc * patofyziologie komplikace terapie MeSH
- senioři MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
BACKGROUND: This study investigated the subthalamic nucleus (STN) function and deep brain stimulation (DBS) effects on single-unit activity (SUA) in Parkinson's disease (PD) patients with dysarthria. METHODS: After presurgical speech analysis, we recorded STN neuronal activities while PD patients (n = 16) articulated Chinese Pinyin consonants. The Pinyin consonants were categorized by the manner and place of articulation for SUA cluster analysis. The cohort was then divided into normal articulation and dysarthria groups based on diadochokinetic (DDK) assessments. The STN SUA patterns, represented by the mean firing rate (FR), peak time, and response intensity during articulation, were analyzed and compared between the two groups. Finally, a stimulation cohort of 7 PD patients was included to test articulation and SUA pattern changes following intraoperative DBS. RESULTS: Clustering analysis of STN neuronal firing patterns demonstrated that neurons encode articulation by grouping consonants with the same manner of articulation into distinct clusters. Using k-means clustering, we further classified SUAs into two waveform types: negative spikes (type 1) and positive spikes (type 2). Dysarthria patients exhibited an increased mean FR of type 1 spikes and a reduced response intensity of type 2 spikes. During intraoperative stimulation, PD patients showed accelerated DDK, accompanied by a decrease in type 1 mean FR and an increase in type 2 mean FR. CONCLUSION: Our findings indicate the crucial role of the STN in consonant encoding and dysarthria at the single-unit level. Both SUA firing patterns in the STN and DDK performance can be modulated by DBS.
Department of Neurosurgery Beijing Tiantan Hospital Capital Medical University Beijing China
Department of Pain Management China Japan Friendship Hospital Beijing China
Program in Speech and Hearing Bioscience and Technology Harvard Medical School Boston MA USA
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc25009356
- 003
- CZ-PrNML
- 005
- 20250429135002.0
- 007
- ta
- 008
- 250415e20250203xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.nbd.2025.106830 $2 doi
- 035 __
- $a (PubMed)39909084
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Diao, Yu $u Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Department of Pain Management, China-Japan Friendship Hospital, Beijing, China
- 245 10
- $a Abnormal neuronal activity in the subthalamic nucleus contributes to dysarthria in patients with Parkinson's disease / $c Y. Diao, Z. Yin, B. Zhao, Y. Xu, Y. Jiang, Y. Yin, A. Yang, Y. Zhu, J. Hlavnicka, J. Zhang
- 520 9_
- $a BACKGROUND: This study investigated the subthalamic nucleus (STN) function and deep brain stimulation (DBS) effects on single-unit activity (SUA) in Parkinson's disease (PD) patients with dysarthria. METHODS: After presurgical speech analysis, we recorded STN neuronal activities while PD patients (n = 16) articulated Chinese Pinyin consonants. The Pinyin consonants were categorized by the manner and place of articulation for SUA cluster analysis. The cohort was then divided into normal articulation and dysarthria groups based on diadochokinetic (DDK) assessments. The STN SUA patterns, represented by the mean firing rate (FR), peak time, and response intensity during articulation, were analyzed and compared between the two groups. Finally, a stimulation cohort of 7 PD patients was included to test articulation and SUA pattern changes following intraoperative DBS. RESULTS: Clustering analysis of STN neuronal firing patterns demonstrated that neurons encode articulation by grouping consonants with the same manner of articulation into distinct clusters. Using k-means clustering, we further classified SUAs into two waveform types: negative spikes (type 1) and positive spikes (type 2). Dysarthria patients exhibited an increased mean FR of type 1 spikes and a reduced response intensity of type 2 spikes. During intraoperative stimulation, PD patients showed accelerated DDK, accompanied by a decrease in type 1 mean FR and an increase in type 2 mean FR. CONCLUSION: Our findings indicate the crucial role of the STN in consonant encoding and dysarthria at the single-unit level. Both SUA firing patterns in the STN and DDK performance can be modulated by DBS.
- 650 _2
- $a lidé $7 D006801
- 650 12
- $a nucleus subthalamicus $x patofyziologie $7 D020531
- 650 12
- $a Parkinsonova nemoc $x patofyziologie $x komplikace $x terapie $7 D010300
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 12
- $a dysartrie $x etiologie $x patofyziologie $7 D004401
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a lidé středního věku $7 D008875
- 650 12
- $a hluboká mozková stimulace $x metody $7 D046690
- 650 _2
- $a senioři $7 D000368
- 650 12
- $a neurony $x fyziologie $7 D009474
- 650 _2
- $a akční potenciály $x fyziologie $7 D000200
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Yin, Zixiao $u Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- 700 1_
- $a Zhao, Baotian $u Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- 700 1_
- $a Xu, Yichen $u Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China
- 700 1_
- $a Jiang, Yin $u Department of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China
- 700 1_
- $a Yin, Yanling $u Department of Neurobiology, School of Basic Medical Sciences, Capital Medical University, Beijing 100069, People's Republic of China
- 700 1_
- $a Yang, Anchao $u Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Department of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China
- 700 1_
- $a Zhu, Yanming $u Program in Speech and Hearing Bioscience and Technology, Harvard Medical School, Boston, MA, USA
- 700 1_
- $a Hlavnicka, Jan $u Centre of Clinical Neuroscience, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic; Department of Circuit Theory, Faculty of Electrical Engineering, Czech Technical University in Prague, Prague, Czech Republic
- 700 1_
- $a Zhang, Jianguo $u Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Department of Functional Neurosurgery, Beijing Neurosurgical Institute, Capital Medical University, Beijing, China. Electronic address: zjguo73@126.com
- 773 0_
- $w MED00008403 $t Neurobiology of disease $x 1095-953X $g Roč. 207 (20250203), s. 106830
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/39909084 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y - $z 0
- 990 __
- $a 20250415 $b ABA008
- 991 __
- $a 20250429134957 $b ABA008
- 999 __
- $a ok $b bmc $g 2311000 $s 1246437
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2025 $b 207 $c - $d 106830 $e 20250203 $i 1095-953X $m Neurobiology of disease $n Neurobiol Dis $x MED00008403
- LZP __
- $a Pubmed-20250415
