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Spatio-temporal mechanisms of consolidation, recall and reconsolidation in reward-related memory trace
A. Hamed, MB. Kursa, W. Mrozek, KP. Piwoński, M. Falińska, K. Danielewski, E. Rejmak, U. Włodkowska, S. Kubik, R. Czajkowski
Language English Country England, Great Britain
Document type Journal Article
Grant support
Sonata-bis 2014/14/E/NZ4/00172
Narodowe Centrum Nauki (National Science Centre)
Opus 2018/29/B/NZ7/02021
Narodowe Centrum Nauki (National Science Centre)
Opus Opus 2023/51/B/NZ7/02350
Narodowe Centrum Nauki (National Science Centre)
- MeSH
- Amphetamine pharmacology MeSH
- Amygdala physiology MeSH
- Hippocampus * physiology MeSH
- Memory Consolidation * physiology MeSH
- Rats MeSH
- Brain physiology MeSH
- Neurons physiology metabolism MeSH
- Nucleus Accumbens * physiology MeSH
- Reward * MeSH
- Memory physiology MeSH
- Cues MeSH
- Prefrontal Cortex physiology MeSH
- Mental Recall * physiology MeSH
- Machine Learning MeSH
- Ventral Tegmental Area * physiology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
The formation of memories is a complex, multi-scale phenomenon, especially when it involves integration of information from various brain systems. We have investigated the differences between a novel and consolidated association of spatial cues and amphetamine administration, using an in situ hybridisation method to track the short-term dynamics during the recall testing. We have found that remote recall group involves smaller, but more consolidated groups of neurons, which is consistent with their specialisation. By employing machine learning analysis, we have shown this pattern is especially pronounced in the VTA; furthermore, we also uncovered significant activity patterns in retrosplenial and prefrontal cortices, as well as in the DG and CA3 subfields of the hippocampus. The behavioural propensity towards the associated localisation appears to be driven by the nucleus accumbens, however, further modulated by a trio of the amygdala, VTA and hippocampus, as the trained association is confronted with test experience. Moreover, chemogenetic analysis revealed central amygdala as critical for linking appetitive emotional states with spatial contexts. These results show that memory mechanisms must be modelled considering individual differences in motivation, as well as covering dynamics of the process.
BRAINCITY Nencki Institute of Experimental Biology Polish Academy of Sciences Warsaw Poland
Institute of Physiology Academy of Sciences of the Czech Republic Praha Czechia
References provided by Crossref.org
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