The Paper that Restarted Modern Central Nervous System Axon Regeneration Research
Jazyk angličtina Země Anglie, Velká Británie Médium print
Typ dokumentu časopisecké články, práce podpořená grantem, komentáře
Grantová podpora
MR/R004463/1
Medical Research Council - United Kingdom
MR/R004544/1
Medical Research Council - United Kingdom
PubMed
29703373
DOI
10.1016/j.tins.2018.02.012
PII: S0166-2236(18)30061-4
Knihovny.cz E-zdroje
- Klíčová slova
- axon regeneration, spinal cord injury,
- MeSH
- axony MeSH
- centrální nervový systém MeSH
- krysa rodu Rattus MeSH
- periferní nervový systém MeSH
- poranění míchy * MeSH
- poranění nervového systému * MeSH
- regenerace nervu MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- komentáře MeSH
- práce podpořená grantem MeSH
Spinal cord repair research appeared to have run out of new ideas in the 1970s. In a 1981 paper, the Aguayo Laboratory revisited an experiment by Tello and Cajal that suggested that central nervous system (CNS) axons could regenerate into peripheral nerve grafts. Using modern axon tracing methods, David and Aguayo showed that axons from neurons in the spinal cord could regenerate for long distances within peripheral nervous system (PNS) grafts, but not back into the CNS. This proved that damaged CNS tissue is inhibitory to axon regeneration while PNS tissue is permissive. The experiment sparked a research revival, leading to the identification of many inhibitory molecules that block axon growth in the mature CNS.
Citace poskytuje Crossref.org
The Struggle to Make CNS Axons Regenerate: Why Has It Been so Difficult?
