The Paper that Restarted Modern Central Nervous System Axon Regeneration Research
Language English Country England, Great Britain Media print
Document type Journal Article, Research Support, Non-U.S. Gov't, Comment
Grant support
MR/R004463/1
Medical Research Council - United Kingdom
MR/R004544/1
Medical Research Council - United Kingdom
PubMed
29703373
DOI
10.1016/j.tins.2018.02.012
PII: S0166-2236(18)30061-4
Knihovny.cz E-resources
- Keywords
- axon regeneration, spinal cord injury,
- MeSH
- Axons MeSH
- Central Nervous System MeSH
- Rats MeSH
- Peripheral Nervous System MeSH
- Spinal Cord Injuries * MeSH
- Trauma, Nervous System * MeSH
- Nerve Regeneration MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Comment MeSH
- Research Support, Non-U.S. Gov't MeSH
Spinal cord repair research appeared to have run out of new ideas in the 1970s. In a 1981 paper, the Aguayo Laboratory revisited an experiment by Tello and Cajal that suggested that central nervous system (CNS) axons could regenerate into peripheral nerve grafts. Using modern axon tracing methods, David and Aguayo showed that axons from neurons in the spinal cord could regenerate for long distances within peripheral nervous system (PNS) grafts, but not back into the CNS. This proved that damaged CNS tissue is inhibitory to axon regeneration while PNS tissue is permissive. The experiment sparked a research revival, leading to the identification of many inhibitory molecules that block axon growth in the mature CNS.
References provided by Crossref.org
The Struggle to Make CNS Axons Regenerate: Why Has It Been so Difficult?
