Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

International Consensus on Evidence Gaps and Research Opportunities in Extracorporeal Cardiopulmonary Resuscitation for Refractory Out-of-Hospital Cardiac Arrest: A Report From the National Heart, Lung, and Blood Institute Workshop

LJ. Morrison, EA. Hunt, B. Grunau, TP. Aufderheide, C. Callaway, JE. Tonna, C. Sasson, A. Blewer, BF. McNally, D. Yannopoulos, J. Belohlavek, J. Bartos, A. Combes, A. Idris, RM. Merchant, L. States, E. Tinsley, R. Wong, ST. Youngquist, G. Sopko, KB. Kern

. 2025 ; 14 (6) : e036108. [pub] 20250305

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc25009476

The increased accessibility of extracorporeal membrane oxygenation following the COVID-19 pandemic and the publication of the first randomized trial of extracorporeal cardiopulmonary resuscitation (ECPR) prompted the National Heart, Lung, and Blood Institute to sponsor a workshop on ECPR. Two more randomized trials have since been published in 2022 and 2023. Based on the combined findings and review of the evidence, an international panel of authors identified gaps in science, inequities in care and diversity in outcomes, and suggested research opportunities and next steps. The science pertaining to ECPR would benefit from the United States contributing uniform data to existing registries and sharing common data with the ELSO (Extracorporeal Life Support Organization) international registry to increase the sample size for observational research. In addition, well-designed efficacy trials, recruiting across different regions of care evaluating long-term follow-up, including patient reported outcomes, cost effectiveness, and equity measures, would contribute significantly to the body of science. Workshop participants defined the population of patients with out-of-hospital cardiac arrest most likely to benefit from ECPR. ECPR-eligible patients include those aged 18 to 75 years functioning independently without comorbidity; before suffering a witnessed out-of-hospital cardiac arrest and without any obvious cause of the cardiac arrest; presenting in a shockable rhythm and transported with mechanical cardiopulmonary resuscitation to an ECPR-capable institute within 30 minutes, which is recommended after 3 rounds of advanced life support treatment without return of spontaneous circulation. There are significant inequities in out-of-hospital cardiac arrest care that need to be addressed such that outcomes are optimized for each target region before implementing ECPR in a clinical or implementation trial.

American Heart Association Dallas TX USA

Anesthesiology and Critical Care Medicine and Pediatrics Johns Hopkins University School of Medicine Baltimore MD USA

Cardiology Sarver Heart Center University of Arizona Tucson AZ USA

Cardiology University of Minnesota Minnesota Resuscitation Consortium Minneapolis MN USA

Cardiothoracic Critical Care Division of Cardiothoracic Surgery and Department of Surgery and Department of Emergency Medicine University of Utah Health Salt Lake City UT USA

Department of Emergency Medicine St Paul's Hospital and the University of British Columbia Centre for Advancing Health Outcomes Vancouver BC Canada

Department of Family Medicine and Community Health and Population Health Sciences Duke University School of Medicine Durham NC USA

Department of Internal Medicine 2 Cardiovascular Medicine General University Hospital and 1st Medical School Charles University Prague Czech Republic

Division of Cardiovascular Sciences NHLBI NIH Bethesda MD USA

Emergency Medicine Anesthesiology and Critical Care Center for Digital Health University of Pennsylvania Philadelphia PA USA

Emergency Medicine Emory University Atlanta GA USA

Emergency Medicine Medical College of Wisconsin Milwaukee WI USA

Emergency Medicine Medicine University of Toronto Emergency Services Sunnybrook Health Sciences Centre Toronto Ontario Canada

Emergency Medicine University of Pittsburgh Pittsburgh PA USA

Emergency Medicine University of Utah Medical Center Salt Lake City UT USA

Intensive Care Medicine Sorbonne Université APHP La Pitié Salpêtrière Hospital Paris France

Office of Science and Medicine Office of the Assistant Secretary for Health Washington DC USA

Surgery and Emergency Medicine University of Texas Southwestern Dallas TX USA

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc25009476
003      
CZ-PrNML
005      
20250429135400.0
007      
ta
008      
250415s2025 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1161/JAHA.124.036108 $2 doi
035    __
$a (PubMed)40040619
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Morrison, Laurie J $u Emergency Medicine, Medicine University of Toronto, Emergency Services, Sunnybrook Health Sciences Centre Toronto Ontario Canada $1 https://orcid.org/0000000183699774
245    10
$a International Consensus on Evidence Gaps and Research Opportunities in Extracorporeal Cardiopulmonary Resuscitation for Refractory Out-of-Hospital Cardiac Arrest: A Report From the National Heart, Lung, and Blood Institute Workshop / $c LJ. Morrison, EA. Hunt, B. Grunau, TP. Aufderheide, C. Callaway, JE. Tonna, C. Sasson, A. Blewer, BF. McNally, D. Yannopoulos, J. Belohlavek, J. Bartos, A. Combes, A. Idris, RM. Merchant, L. States, E. Tinsley, R. Wong, ST. Youngquist, G. Sopko, KB. Kern
520    9_
$a The increased accessibility of extracorporeal membrane oxygenation following the COVID-19 pandemic and the publication of the first randomized trial of extracorporeal cardiopulmonary resuscitation (ECPR) prompted the National Heart, Lung, and Blood Institute to sponsor a workshop on ECPR. Two more randomized trials have since been published in 2022 and 2023. Based on the combined findings and review of the evidence, an international panel of authors identified gaps in science, inequities in care and diversity in outcomes, and suggested research opportunities and next steps. The science pertaining to ECPR would benefit from the United States contributing uniform data to existing registries and sharing common data with the ELSO (Extracorporeal Life Support Organization) international registry to increase the sample size for observational research. In addition, well-designed efficacy trials, recruiting across different regions of care evaluating long-term follow-up, including patient reported outcomes, cost effectiveness, and equity measures, would contribute significantly to the body of science. Workshop participants defined the population of patients with out-of-hospital cardiac arrest most likely to benefit from ECPR. ECPR-eligible patients include those aged 18 to 75 years functioning independently without comorbidity; before suffering a witnessed out-of-hospital cardiac arrest and without any obvious cause of the cardiac arrest; presenting in a shockable rhythm and transported with mechanical cardiopulmonary resuscitation to an ECPR-capable institute within 30 minutes, which is recommended after 3 rounds of advanced life support treatment without return of spontaneous circulation. There are significant inequities in out-of-hospital cardiac arrest care that need to be addressed such that outcomes are optimized for each target region before implementing ECPR in a clinical or implementation trial.
650    _2
$a lidé $7 D006801
650    12
$a zástava srdce mimo nemocnici $x terapie $7 D058687
650    12
$a mimotělní membránová oxygenace $x metody $7 D015199
650    12
$a kardiopulmonální resuscitace $x metody $7 D016887
650    12
$a National Heart, Lung, and Blood Institute (U.S.) $7 D054555
650    _2
$a COVID-19 $x epidemiologie $x terapie $7 D000086382
650    _2
$a konsensus $7 D032921
650    _2
$a SARS-CoV-2 $7 D000086402
650    _2
$a mezery v důkazech $7 D000094505
651    _2
$a Spojené státy americké $x epidemiologie $7 D014481
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a Hunt, Elizabeth A $u Anesthesiology & Critical Care Medicine and Pediatrics Johns Hopkins University School of Medicine Baltimore MD USA $1 https://orcid.org/0000000200536265
700    1_
$a Grunau, Brian $u Department of Emergency Medicine St. Paul's Hospital, and the University of British Columbia (BC), Centre for Advancing Health Outcomes Vancouver BC Canada $1 https://orcid.org/0000000341031383
700    1_
$a Aufderheide, Thomas P $u Emergency Medicine Medical College of Wisconsin Milwaukee WI USA
700    1_
$a Callaway, Clifton $u Emergency Medicine University of Pittsburgh Pittsburgh PA USA
700    1_
$a Tonna, Joseph E $u Cardiothoracic Critical Care, Division of Cardiothoracic Surgery and Department of Surgery and Department of Emergency Medicine University of Utah Health Salt Lake City UT USA $1 https://orcid.org/0000000188792628
700    1_
$a Sasson, Comilla $u American Heart Association Dallas TX USA $1 https://orcid.org/0000000299226637
700    1_
$a Blewer, Audrey $u Department of Family Medicine and Community Health and Population Health Sciences Duke University School of Medicine Durham NC USA $1 https://orcid.org/0000000328305191
700    1_
$a McNally, Bryan F $u Emergency Medicine Emory University Atlanta GA USA $1 https://orcid.org/0000000335321931
700    1_
$a Yannopoulos, Demetris $u Cardiology University of Minnesota, Minnesota Resuscitation Consortium Minneapolis MN USA $1 https://orcid.org/0000000271312015
700    1_
$a Belohlavek, Jan $u Department of Internal Medicine II, Cardiovascular Medicine General University Hospital and 1st Medical School, Charles University Prague Czech Republic $1 https://orcid.org/0000000194559224 $7 xx0077681
700    1_
$a Bartos, Jason $u Cardiology University of Minnesota, Minnesota Resuscitation Consortium Minneapolis MN USA $1 https://orcid.org/0000000301135305
700    1_
$a Combes, Alain $u Intensive Care Medicine Sorbonne Université, APHP, La Pitié-Salpêtrière Hospital Paris France $1 https://orcid.org/0000000260303957 $7 xx0257917
700    1_
$a Idris, Ahamed $u Surgery and Emergency Medicine University of Texas Southwestern Dallas TX USA $1 https://orcid.org/0000000171136499
700    1_
$a Merchant, Raina M $u Emergency Medicine, Anesthesiology and Critical Care, Center for Digital Health University of Pennsylvania Philadelphia PA USA
700    1_
$a States, Leith $u Office of Science and Medicine Office of the Assistant Secretary for Health (OASH) Washington DC USA
700    1_
$a Tinsley, Emily $u Division of Cardiovascular Sciences NHLBI, NIH Bethesda MD USA
700    1_
$a Wong, Renee $u Division of Cardiovascular Sciences NHLBI, NIH Bethesda MD USA $1 https://orcid.org/0009000058254642
700    1_
$a Youngquist, Scott T $u Emergency Medicine University of Utah Medical Center Salt Lake City UT USA $1 https://orcid.org/0000000223439521
700    1_
$a Sopko, George $u Division of Cardiovascular Sciences NHLBI, NIH Bethesda MD USA $1 https://orcid.org/0000000254828992
700    1_
$a Kern, Karl B $u Cardiology, Sarver Heart Center University of Arizona Tucson AZ USA $1 https://orcid.org/0000000283348189
773    0_
$w MED00188127 $t Journal of the American Heart Association $x 2047-9980 $g Roč. 14, č. 6 (2025), s. e036108
856    41
$u https://pubmed.ncbi.nlm.nih.gov/40040619 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20250415 $b ABA008
991    __
$a 20250429135356 $b ABA008
999    __
$a ok $b bmc $g 2311077 $s 1246557
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2025 $b 14 $c 6 $d e036108 $e 20250305 $i 2047-9980 $m Journal of the American Heart Association $n J Am Heart Assoc $x MED00188127
LZP    __
$a Pubmed-20250415

Najít záznam

Citační ukazatele

Možnosti archivace