-
Je něco špatně v tomto záznamu ?
Reduced removal of waste products from energy metabolism takes center stage in human brain aging
S. Mangia, M. DiNuzzo, S. Ponticorvo, GA. Dienel, KL. Behar, H. Benveniste, F. Hyder, F. Giove, S. Herculano-Houzel, OA. Petroff, LE. Eberly, P. Filip, S. Michaeli, DL. Rothman
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články
Grantová podpora
P41 EB027061
NIBIB NIH HHS - United States
R01 NS100106
NINDS NIH HHS - United States
P41 EB027061
NIH HHS - United States
R01 AG087526
NIA NIH HHS - United States
R01 MH109159
NIMH NIH HHS - United States
R01 NS087568
NINDS NIH HHS - United States
R56 AG079086
NIA NIH HHS - United States
R01 AG087526
NIH HHS - United States
DP1 AG093028
NIA NIH HHS - United States
NLK
Directory of Open Access Journals
od 2011
Free Medical Journals
od 2011
Nature Open Access
od 2011-12-01
PubMed Central
od 2011
Europe PubMed Central
od 2011
ProQuest Central
od 2011-01-01
Open Access Digital Library
od 2011-01-01
Open Access Digital Library
od 2011-01-01
Health & Medicine (ProQuest)
od 2011-01-01
ROAD: Directory of Open Access Scholarly Resources
od 2011
Springer Nature OA/Free Journals
od 2011-12-01
- MeSH
- dospělí MeSH
- energetický metabolismus * MeSH
- koncentrace vodíkových iontů MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mozek * metabolismus MeSH
- mozkový krevní oběh * fyziologie MeSH
- oxid uhličitý * metabolismus MeSH
- pozitronová emisní tomografie * MeSH
- senioři MeSH
- spotřeba kyslíku MeSH
- stárnutí * metabolismus fyziologie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Despite extensive research on neuroimaging correlates of human brain aging, there is little mechanistic insight into how they are linked to loss of brain function. Previous studies on the role of cerebral blood flow (CBF) in supporting brain function have focused on delivery of nutrients, namely oxygen and glucose. However, CBF is required also to clear the byproducts of energy metabolism, namely CO2 and protons. With the goal of determining whether age-associated reduction in regional CBF may lead to abnormal brain partial pressure of carbon dioxide (pCO2) and pH levels that are sufficient to alter brain activity and cognitive function, we applied a recently introduced homeostatic modeling of nutrients and waste products to human neuroimaging PET data acquired in young and older adults (Goyal et al. in Cell Metab 26(2):353-360, 2017). Our results demonstrate that age-associated reductions in CBF, in the presence of virtually unaltered oxygen consumption rates, show concurrent regional age-associated increases in pCO2 and associated pH acid-shifts of possible functional relevance. We conclude that the implications of altered vascular health in older adults needs to be revisited in light of its central role in removing waste products from energy metabolism at resting state and, in future studies, during external stimulations.
Centro Ricerche Enrico Fermi Rome RM Italy
Department of Anesthesiology Yale University New Haven CT USA
Department of Biomedical Engineering Yale University New Haven CT USA
Department of Neurology University of Arkansas for Medical Sciences Little Rock AR USA
Department of Neurology Yale University School of Medicine New Haven CT USA
Department of Psychiatry Yale University School of Medicine New Haven CT USA
Department of Psychology Vanderbilt University Nashville TN USA
Department of Radiology Magnetic Resonance Research Center Yale University New Haven CT USA
Division of Biostatistics School of Public Health University of Minnesota Minneapolis MN USA
Fondazione Santa Lucia IRCCS Rome RM Italy
Vanderbilt Brain Institute Vanderbilt University Nashville TN USA
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc25009542
- 003
- CZ-PrNML
- 005
- 20250429135309.0
- 007
- ta
- 008
- 250415s2025 enk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1038/s41598-025-90342-3 $2 doi
- 035 __
- $a (PubMed)40057554
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a enk
- 100 1_
- $a Mangia, Silvia $u Department of Radiology, Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA. mangia@umn.edu
- 245 10
- $a Reduced removal of waste products from energy metabolism takes center stage in human brain aging / $c S. Mangia, M. DiNuzzo, S. Ponticorvo, GA. Dienel, KL. Behar, H. Benveniste, F. Hyder, F. Giove, S. Herculano-Houzel, OA. Petroff, LE. Eberly, P. Filip, S. Michaeli, DL. Rothman
- 520 9_
- $a Despite extensive research on neuroimaging correlates of human brain aging, there is little mechanistic insight into how they are linked to loss of brain function. Previous studies on the role of cerebral blood flow (CBF) in supporting brain function have focused on delivery of nutrients, namely oxygen and glucose. However, CBF is required also to clear the byproducts of energy metabolism, namely CO2 and protons. With the goal of determining whether age-associated reduction in regional CBF may lead to abnormal brain partial pressure of carbon dioxide (pCO2) and pH levels that are sufficient to alter brain activity and cognitive function, we applied a recently introduced homeostatic modeling of nutrients and waste products to human neuroimaging PET data acquired in young and older adults (Goyal et al. in Cell Metab 26(2):353-360, 2017). Our results demonstrate that age-associated reductions in CBF, in the presence of virtually unaltered oxygen consumption rates, show concurrent regional age-associated increases in pCO2 and associated pH acid-shifts of possible functional relevance. We conclude that the implications of altered vascular health in older adults needs to be revisited in light of its central role in removing waste products from energy metabolism at resting state and, in future studies, during external stimulations.
- 650 _2
- $a lidé $7 D006801
- 650 12
- $a energetický metabolismus $7 D004734
- 650 12
- $a stárnutí $x metabolismus $x fyziologie $7 D000375
- 650 12
- $a mozek $x metabolismus $7 D001921
- 650 _2
- $a senioři $7 D000368
- 650 12
- $a mozkový krevní oběh $x fyziologie $7 D002560
- 650 12
- $a oxid uhličitý $x metabolismus $7 D002245
- 650 _2
- $a dospělí $7 D000328
- 650 12
- $a pozitronová emisní tomografie $7 D049268
- 650 _2
- $a koncentrace vodíkových iontů $7 D006863
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a spotřeba kyslíku $7 D010101
- 650 _2
- $a mladý dospělý $7 D055815
- 650 _2
- $a lidé středního věku $7 D008875
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a DiNuzzo, Mauro $u Netabolics SRL, Rome, RM, Italy
- 700 1_
- $a Ponticorvo, Sara $u Department of Radiology, Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA
- 700 1_
- $a Dienel, Gerald A $u Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR, USA $u Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, NM, USA
- 700 1_
- $a Behar, Kevin L $u Department of Psychiatry, Yale University, School of Medicine, New Haven, CT, USA
- 700 1_
- $a Benveniste, Helene $u Department of Anesthesiology, Yale University, New Haven, CT, USA $u Department of Biomedical Engineering, Yale University, New Haven, CT, USA
- 700 1_
- $a Hyder, Fahmeed $u Department of Biomedical Engineering, Yale University, New Haven, CT, USA $u Department of Radiology, Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT, USA
- 700 1_
- $a Giove, Federico $u Centro Ricerche Enrico Fermi, Rome, RM, Italy $u Fondazione Santa Lucia IRCCS, Rome, RM, Italy
- 700 1_
- $a Herculano-Houzel, Suzana $u Department of Psychology, Vanderbilt University, Nashville, TN, USA $u Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA
- 700 1_
- $a Petroff, Ognen A $u Department of Neurology, Yale University, School of Medicine, New Haven, CT, USA
- 700 1_
- $a Eberly, Lynn E $u Department of Radiology, Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA $u Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA
- 700 1_
- $a Filip, Pavel $u Department of Radiology, Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA $u Department of Neurology, First Faculty of Medicine and General University Hospital, 121 08, Prague, Czech Republic
- 700 1_
- $a Michaeli, Shalom $u Department of Radiology, Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA
- 700 1_
- $a Rothman, Douglas L $u Department of Biomedical Engineering, Yale University, New Haven, CT, USA $u Department of Radiology, Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT, USA
- 773 0_
- $w MED00182195 $t Scientific reports $x 2045-2322 $g Roč. 15, č. 1 (2025), s. 8127
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/40057554 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y - $z 0
- 990 __
- $a 20250415 $b ABA008
- 991 __
- $a 20250429135304 $b ABA008
- 999 __
- $a ok $b bmc $g 2311121 $s 1246623
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2025 $b 15 $c 1 $d 8127 $e 20250308 $i 2045-2322 $m Scientific reports $n Sci Rep $x MED00182195
- GRA __
- $a P41 EB027061 $p NIBIB NIH HHS $2 United States
- GRA __
- $a R01 NS100106 $p NINDS NIH HHS $2 United States
- GRA __
- $a P41 EB027061 $p NIH HHS $2 United States
- GRA __
- $a R01 AG087526 $p NIA NIH HHS $2 United States
- GRA __
- $a R01 MH109159 $p NIMH NIH HHS $2 United States
- GRA __
- $a R01 NS087568 $p NINDS NIH HHS $2 United States
- GRA __
- $a R56 AG079086 $p NIA NIH HHS $2 United States
- GRA __
- $a R01 AG087526 $p NIH HHS $2 United States
- GRA __
- $a DP1 AG093028 $p NIA NIH HHS $2 United States
- LZP __
- $a Pubmed-20250415