Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Reduced removal of waste products from energy metabolism takes center stage in human brain aging

S. Mangia, M. DiNuzzo, S. Ponticorvo, GA. Dienel, KL. Behar, H. Benveniste, F. Hyder, F. Giove, S. Herculano-Houzel, OA. Petroff, LE. Eberly, P. Filip, S. Michaeli, DL. Rothman

. 2025 ; 15 (1) : 8127. [pub] 20250308

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc25009542

Grantová podpora
P41 EB027061 NIBIB NIH HHS - United States
R01 NS100106 NINDS NIH HHS - United States
P41 EB027061 NIH HHS - United States
R01 AG087526 NIA NIH HHS - United States
R01 MH109159 NIMH NIH HHS - United States
R01 NS087568 NINDS NIH HHS - United States
R56 AG079086 NIA NIH HHS - United States
R01 AG087526 NIH HHS - United States
DP1 AG093028 NIA NIH HHS - United States

Despite extensive research on neuroimaging correlates of human brain aging, there is little mechanistic insight into how they are linked to loss of brain function. Previous studies on the role of cerebral blood flow (CBF) in supporting brain function have focused on delivery of nutrients, namely oxygen and glucose. However, CBF is required also to clear the byproducts of energy metabolism, namely CO2 and protons. With the goal of determining whether age-associated reduction in regional CBF may lead to abnormal brain partial pressure of carbon dioxide (pCO2) and pH levels that are sufficient to alter brain activity and cognitive function, we applied a recently introduced homeostatic modeling of nutrients and waste products to human neuroimaging PET data acquired in young and older adults (Goyal et al. in Cell Metab 26(2):353-360, 2017). Our results demonstrate that age-associated reductions in CBF, in the presence of virtually unaltered oxygen consumption rates, show concurrent regional age-associated increases in pCO2 and associated pH acid-shifts of possible functional relevance. We conclude that the implications of altered vascular health in older adults needs to be revisited in light of its central role in removing waste products from energy metabolism at resting state and, in future studies, during external stimulations.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc25009542
003      
CZ-PrNML
005      
20250429135309.0
007      
ta
008      
250415s2025 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1038/s41598-025-90342-3 $2 doi
035    __
$a (PubMed)40057554
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Mangia, Silvia $u Department of Radiology, Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA. mangia@umn.edu
245    10
$a Reduced removal of waste products from energy metabolism takes center stage in human brain aging / $c S. Mangia, M. DiNuzzo, S. Ponticorvo, GA. Dienel, KL. Behar, H. Benveniste, F. Hyder, F. Giove, S. Herculano-Houzel, OA. Petroff, LE. Eberly, P. Filip, S. Michaeli, DL. Rothman
520    9_
$a Despite extensive research on neuroimaging correlates of human brain aging, there is little mechanistic insight into how they are linked to loss of brain function. Previous studies on the role of cerebral blood flow (CBF) in supporting brain function have focused on delivery of nutrients, namely oxygen and glucose. However, CBF is required also to clear the byproducts of energy metabolism, namely CO2 and protons. With the goal of determining whether age-associated reduction in regional CBF may lead to abnormal brain partial pressure of carbon dioxide (pCO2) and pH levels that are sufficient to alter brain activity and cognitive function, we applied a recently introduced homeostatic modeling of nutrients and waste products to human neuroimaging PET data acquired in young and older adults (Goyal et al. in Cell Metab 26(2):353-360, 2017). Our results demonstrate that age-associated reductions in CBF, in the presence of virtually unaltered oxygen consumption rates, show concurrent regional age-associated increases in pCO2 and associated pH acid-shifts of possible functional relevance. We conclude that the implications of altered vascular health in older adults needs to be revisited in light of its central role in removing waste products from energy metabolism at resting state and, in future studies, during external stimulations.
650    _2
$a lidé $7 D006801
650    12
$a energetický metabolismus $7 D004734
650    12
$a stárnutí $x metabolismus $x fyziologie $7 D000375
650    12
$a mozek $x metabolismus $7 D001921
650    _2
$a senioři $7 D000368
650    12
$a mozkový krevní oběh $x fyziologie $7 D002560
650    12
$a oxid uhličitý $x metabolismus $7 D002245
650    _2
$a dospělí $7 D000328
650    12
$a pozitronová emisní tomografie $7 D049268
650    _2
$a koncentrace vodíkových iontů $7 D006863
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a spotřeba kyslíku $7 D010101
650    _2
$a mladý dospělý $7 D055815
650    _2
$a lidé středního věku $7 D008875
655    _2
$a časopisecké články $7 D016428
700    1_
$a DiNuzzo, Mauro $u Netabolics SRL, Rome, RM, Italy
700    1_
$a Ponticorvo, Sara $u Department of Radiology, Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA
700    1_
$a Dienel, Gerald A $u Department of Neurology, University of Arkansas for Medical Sciences, Little Rock, AR, USA $u Department of Cell Biology and Physiology, University of New Mexico School of Medicine, Albuquerque, NM, USA
700    1_
$a Behar, Kevin L $u Department of Psychiatry, Yale University, School of Medicine, New Haven, CT, USA
700    1_
$a Benveniste, Helene $u Department of Anesthesiology, Yale University, New Haven, CT, USA $u Department of Biomedical Engineering, Yale University, New Haven, CT, USA
700    1_
$a Hyder, Fahmeed $u Department of Biomedical Engineering, Yale University, New Haven, CT, USA $u Department of Radiology, Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT, USA
700    1_
$a Giove, Federico $u Centro Ricerche Enrico Fermi, Rome, RM, Italy $u Fondazione Santa Lucia IRCCS, Rome, RM, Italy
700    1_
$a Herculano-Houzel, Suzana $u Department of Psychology, Vanderbilt University, Nashville, TN, USA $u Vanderbilt Brain Institute, Vanderbilt University, Nashville, TN, USA
700    1_
$a Petroff, Ognen A $u Department of Neurology, Yale University, School of Medicine, New Haven, CT, USA
700    1_
$a Eberly, Lynn E $u Department of Radiology, Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA $u Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA
700    1_
$a Filip, Pavel $u Department of Radiology, Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA $u Department of Neurology, First Faculty of Medicine and General University Hospital, 121 08, Prague, Czech Republic
700    1_
$a Michaeli, Shalom $u Department of Radiology, Center for Magnetic Resonance Research (CMRR), University of Minnesota, Minneapolis, MN, USA
700    1_
$a Rothman, Douglas L $u Department of Biomedical Engineering, Yale University, New Haven, CT, USA $u Department of Radiology, Magnetic Resonance Research Center (MRRC), Yale University, New Haven, CT, USA
773    0_
$w MED00182195 $t Scientific reports $x 2045-2322 $g Roč. 15, č. 1 (2025), s. 8127
856    41
$u https://pubmed.ncbi.nlm.nih.gov/40057554 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20250415 $b ABA008
991    __
$a 20250429135304 $b ABA008
999    __
$a ok $b bmc $g 2311121 $s 1246623
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2025 $b 15 $c 1 $d 8127 $e 20250308 $i 2045-2322 $m Scientific reports $n Sci Rep $x MED00182195
GRA    __
$a P41 EB027061 $p NIBIB NIH HHS $2 United States
GRA    __
$a R01 NS100106 $p NINDS NIH HHS $2 United States
GRA    __
$a P41 EB027061 $p NIH HHS $2 United States
GRA    __
$a R01 AG087526 $p NIA NIH HHS $2 United States
GRA    __
$a R01 MH109159 $p NIMH NIH HHS $2 United States
GRA    __
$a R01 NS087568 $p NINDS NIH HHS $2 United States
GRA    __
$a R56 AG079086 $p NIA NIH HHS $2 United States
GRA    __
$a R01 AG087526 $p NIH HHS $2 United States
GRA    __
$a DP1 AG093028 $p NIA NIH HHS $2 United States
LZP    __
$a Pubmed-20250415

Najít záznam

Citační ukazatele

Nahrávání dat ...

Možnosti archivace

Nahrávání dat ...