OBJECTIVES: Artificial Intelligence (AI), particularly deep learning, has significantly impacted healthcare, including dentistry, by improving diagnostics, treatment planning, and prognosis prediction. This systematic mapping review explores the current applications of deep learning in dentistry, offering a comprehensive overview of trends, models, and their clinical significance. MATERIALS AND METHODS: Following a structured methodology, relevant studies published from January 2012 to September 2023 were identified through database searches in PubMed, Scopus, and Embase. Key data, including clinical purpose, deep learning tasks, model architectures, and data modalities, were extracted for qualitative synthesis. RESULTS: From 21,242 screened studies, 1,007 were included. Of these, 63.5% targeted diagnostic tasks, primarily with convolutional neural networks (CNNs). Classification (43.7%) and segmentation (22.9%) were the main methods, and imaging data-such as cone-beam computed tomography and orthopantomograms-were used in 84.4% of cases. Most studies (95.2%) applied fully supervised learning, emphasizing the need for annotated data. Pathology (21.5%), radiology (17.5%), and orthodontics (10.2%) were prominent fields, with 24.9% of studies relating to more than one specialty. CONCLUSION: This review explores the advancements in deep learning in dentistry, particulary for diagnostics, and identifies areas for further improvement. While CNNs have been used successfully, it is essential to explore emerging model architectures, learning approaches, and ways to obtain diverse and reliable data. Furthermore, fostering trust among all stakeholders by advancing explainable AI and addressing ethical considerations is crucial for transitioning AI from research to clinical practice. CLINICAL RELEVANCE: This review offers a comprehensive overview of a decade of deep learning in dentistry, showcasing its significant growth in recent years. By mapping its key applications and identifying research trends, it provides a valuable guide for future studies and highlights emerging opportunities for advancing AI-driven dental care.

College of Dentistry University of Saskatchewan Saskatoon SK Canada

Dentofacial Deformities Research Center Research Institute of Dental Sciences Shahid Beheshti University of Medical Sciences Tehran Iran

Department of Conservative Dentistry and Periodontology LMU University Hospital LMU Munich Munich Germany

Department of Dentistry and Oral Health Aarhus University Vennelyst Boulevard 9 Aarhus C 8000 Aarhus Denmark

Department of Orthodontics School of Dentistry Shahid Beheshti University of Medical Sciences Tehran Iran

Division of Orthodontics The Ohio State University Columbus OH 43210 USA

Institute of Dental Medicine 1st Faculty of Medicine of the Charles University and General University Hospital Prague Czech Republic

ITU WHO WIPO Global Initiative on Artificial Intelligence for Health Dental Diagnostics and Digital Dentistry Geneva Switzerland

Medical Physics and Biomedical Engineering Department School of Medicine Tehran University of Medical Sciences Tehran Iran

Research Center for Biomedical Technologies and Robotics Tehran Iran

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