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The Myositis Clinical Trials Consortium: an international collaborative initiative to promote clinical trials in adult and juvenile myositis
A. Bishnoi, IYK. Tang, A. Yoshida, FM. Pais, SY. Usman, SA. Dominguez, CG. Kavadichanda, D. Rivero-Gallegos, E. Dourado, E. Conticini, F. Bozán, G. Tulluru, JB. Lilleker, K. Sreerama Reddy, O. Landon-Cardinal, R. Smaili, S. Keret, T. Khoo, TY....
Language English Country Italy
Document type Journal Article, Review
- MeSH
- Child MeSH
- Adult MeSH
- Clinical Trials as Topic * MeSH
- Cooperative Behavior MeSH
- Humans MeSH
- International Cooperation * MeSH
- Adolescent MeSH
- Myositis * therapy diagnosis MeSH
- Research Design MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Humans MeSH
- Adolescent MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Idiopathic inflammatory myopathies (IIM), or myositis, are a heterogeneous group of systemic autoimmune disorders that are associated with significant morbidity and mortality. Conducting high-quality clinical trials in IIM is challenging due to the rare and variable presentations of disease. To address this challenge, the Myositis Clinical Trials Consortium (MCTC) was formed. MCTC is a collaborative international alliance dedicated to facilitating, promoting, coordinating and conducting clinical trials and related research in IIM. This partnership works to advance the discovery of effective evidence-based treatments for IIM by integrating a diverse group of clinical investigators, research professionals, medical centres, patient groups, and industry partners. The Steering Committee, Core Group, and Paediatric Subcommittee of MCTC are comprised of myositis experts and junior investigators from around the world, representing a diversity of genders, geographies, and subspecialties. MCTC works alongside other current myositis organisations to complement existing work by concentrating on the operationalisation of clinical trials. Our pilot Myositis Investigators' Information Survey gathered responses from 173 myositis investigators globally and found considerable variability in proficiency with outcome measures, geographic disparities in patient recruitment, and a significant disconnect between investigators' routine myositis patient load and clinical trial enrolment. MCTC will meet the need to support and diversify myositis clinical trials by facilitating trial planning, feasibility assessments, site selection, and the training and mentoring of junior investigators/centres to establish their readiness for clinical trial participation. Through experienced leadership, strategic collaborations, and interdisciplinary discussions, MCTC will establish standards for IIM clinical trial design, protocols, and outcome measures in myositis.
Aveiro Rheumatology Research Centre Egas Moniz Health Alliance Aveiro
Department of Allergy and Rheumatology Nippon Medical School Graduate School of Medicine Tokyo Japan
Department of Medicine McGill University Montreal
Division of Rheumatology and Clinical Immunology University of Tangier Morocco
Division of Rheumatology Centre Hospitalier de l'Université de Montréal Canada
Division of Rheumatology Emory University Atlanta GA USA
Division of Rheumatology Jewish General Hospital Montreal Canada
Rheumatology Department Unidade Local de Saúde da Região de Aveiro Aveiro
Rheumatology Unit Department of Medicine Surgery and Neurosciences University of Siena Italy
Section of Rheumatology Department of Medicine Hospital Clínico Universidad de Chile Santiago Chile
References provided by Crossref.org
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- $a Idiopathic inflammatory myopathies (IIM), or myositis, are a heterogeneous group of systemic autoimmune disorders that are associated with significant morbidity and mortality. Conducting high-quality clinical trials in IIM is challenging due to the rare and variable presentations of disease. To address this challenge, the Myositis Clinical Trials Consortium (MCTC) was formed. MCTC is a collaborative international alliance dedicated to facilitating, promoting, coordinating and conducting clinical trials and related research in IIM. This partnership works to advance the discovery of effective evidence-based treatments for IIM by integrating a diverse group of clinical investigators, research professionals, medical centres, patient groups, and industry partners. The Steering Committee, Core Group, and Paediatric Subcommittee of MCTC are comprised of myositis experts and junior investigators from around the world, representing a diversity of genders, geographies, and subspecialties. MCTC works alongside other current myositis organisations to complement existing work by concentrating on the operationalisation of clinical trials. Our pilot Myositis Investigators' Information Survey gathered responses from 173 myositis investigators globally and found considerable variability in proficiency with outcome measures, geographic disparities in patient recruitment, and a significant disconnect between investigators' routine myositis patient load and clinical trial enrolment. MCTC will meet the need to support and diversify myositis clinical trials by facilitating trial planning, feasibility assessments, site selection, and the training and mentoring of junior investigators/centres to establish their readiness for clinical trial participation. Through experienced leadership, strategic collaborations, and interdisciplinary discussions, MCTC will establish standards for IIM clinical trial design, protocols, and outcome measures in myositis.
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