Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

Serotonin attenuates tumor necrosis factor-induced intestinal inflammation by interacting with human mucosal tissue

V. Bosáková, I. Papatheodorou, F. Kafka, Z. Tomášiková, P. Kolovos, M. Hortová Kohoutková, J. Frič

. 2025 ; 57 (2) : 364-378. [pub] 20250203

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc25010004

The intestine hosts the largest immune system and peripheral nervous system in the human body. The gut‒brain axis orchestrates communication between the central and enteric nervous systems, playing a pivotal role in regulating overall body function and intestinal homeostasis. Here, using a human three-dimensional in vitro culture model, we investigated the effects of serotonin, a neuromodulator produced in the gut, on immune cell and intestinal tissue interactions. Serotonin attenuated the tumor necrosis factor-induced proinflammatory response, mostly by affecting the expression of chemokines. Serotonin affected the phenotype and distribution of tissue-migrating monocytes, without direct contact with the cells, by remodeling the intestinal tissue. Collectively, our results show that serotonin plays a crucial role in communication among gut-brain axis components and regulates monocyte migration and plasticity, thereby contributing to gut homeostasis and the progression of inflammation. In vivo studies focused on the role of neuromodulators in gut inflammation have shown controversial results, highlighting the importance of human experimental models. Moreover, our results emphasize the importance of human health research in human cell-based models and suggest that the serotonin signaling pathway is a new therapeutic target for inflammatory bowel disease.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc25010004
003      
CZ-PrNML
005      
20250429135001.0
007      
ta
008      
250415s2025 xxu f 000 0|eng||
009      
AR
024    7_
$a 10.1038/s12276-025-01397-1 $2 doi
035    __
$a (PubMed)39894823
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxu
100    1_
$a Bosáková, Veronika $u International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic $u Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
245    10
$a Serotonin attenuates tumor necrosis factor-induced intestinal inflammation by interacting with human mucosal tissue / $c V. Bosáková, I. Papatheodorou, F. Kafka, Z. Tomášiková, P. Kolovos, M. Hortová Kohoutková, J. Frič
520    9_
$a The intestine hosts the largest immune system and peripheral nervous system in the human body. The gut‒brain axis orchestrates communication between the central and enteric nervous systems, playing a pivotal role in regulating overall body function and intestinal homeostasis. Here, using a human three-dimensional in vitro culture model, we investigated the effects of serotonin, a neuromodulator produced in the gut, on immune cell and intestinal tissue interactions. Serotonin attenuated the tumor necrosis factor-induced proinflammatory response, mostly by affecting the expression of chemokines. Serotonin affected the phenotype and distribution of tissue-migrating monocytes, without direct contact with the cells, by remodeling the intestinal tissue. Collectively, our results show that serotonin plays a crucial role in communication among gut-brain axis components and regulates monocyte migration and plasticity, thereby contributing to gut homeostasis and the progression of inflammation. In vivo studies focused on the role of neuromodulators in gut inflammation have shown controversial results, highlighting the importance of human experimental models. Moreover, our results emphasize the importance of human health research in human cell-based models and suggest that the serotonin signaling pathway is a new therapeutic target for inflammatory bowel disease.
650    12
$a serotonin $x metabolismus $7 D012701
650    _2
$a lidé $7 D006801
650    12
$a střevní sliznice $x metabolismus $x patologie $7 D007413
650    _2
$a zánět $x metabolismus $x patologie $7 D007249
650    _2
$a monocyty $x metabolismus $x imunologie $7 D009000
650    _2
$a TNF-alfa $x metabolismus $7 D014409
650    _2
$a signální transdukce $7 D015398
650    _2
$a pohyb buněk $7 D002465
655    _2
$a časopisecké články $7 D016428
700    1_
$a Papatheodorou, Ioanna $u International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic $u Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
700    1_
$a Kafka, Filip $u International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic $u Department of Biology, Faculty of Medicine, Masaryk University, Brno, Czech Republic
700    1_
$a Tomášiková, Zuzana $u International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic $u Department of Experimental Biology, Faculty of Science, Masaryk University, Brno, Czech Republic
700    1_
$a Kolovos, Petros $u Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupolis, Greece
700    1_
$a Hortová Kohoutková, Marcela $u International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic. marcela.hortova.kohoutkova@med.muni.cz $u International Clinical Research Center, Faculty of Medicine, Masaryk University, Brno, Czech Republic. marcela.hortova.kohoutkova@med.muni.cz
700    1_
$a Frič, Jan $u International Clinical Research Center, St. Anne's University Hospital, Brno, Czech Republic. jan.fric@fnusa.cz $u International Clinical Research Center, Faculty of Medicine, Masaryk University, Brno, Czech Republic. jan.fric@fnusa.cz $u Institute of Hematology and Blood Transfusion, Prague, Czech Republic. jan.fric@fnusa.cz
773    0_
$w MED00008294 $t Experimental and Molecular Medicine $x 2092-6413 $g Roč. 57, č. 2 (2025), s. 364-378
856    41
$u https://pubmed.ncbi.nlm.nih.gov/39894823 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y - $z 0
990    __
$a 20250415 $b ABA008
991    __
$a 20250429134957 $b ABA008
999    __
$a ok $b bmc $g 2311398 $s 1247085
BAS    __
$a 3
BAS    __
$a PreBMC-MEDLINE
BMC    __
$a 2025 $b 57 $c 2 $d 364-378 $e 20250203 $i 2092-6413 $m Experimental and Molecular Medicine $n Exp Mol Med $x MED00008294
LZP    __
$a Pubmed-20250415

Najít záznam

Citační ukazatele

Možnosti archivace