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Centenarians-the way to healthy vascular ageing and longevity: a review from VascAgeNet
S. Summer, M. Borrell-Pages, RM. Bruno, RE. Climie, K. Dipla, A. Dogan, K. Eruslanova, E. Fraenkel, F. Mattace-Raso, CJA. Pugh, KD. Rochfort, M. Ross, L. Roth, A. Schmidt-Trucksäss, D. Schwarz, J. Shadiow, Y. Sohrabi, J. Sonnenberg, O....
Language English Country Switzerland
Document type Journal Article, Review
Grant support
CA18216
European Cooperation in Science and Technology
NLK
Free Medical Journals
from 2017
PubMed Central
from 2017
Europe PubMed Central
from 2017
- MeSH
- Longevity * physiology MeSH
- Cardiovascular Diseases physiopathology epidemiology MeSH
- Humans MeSH
- Oxidative Stress physiology MeSH
- Risk Factors MeSH
- Aged, 80 and over MeSH
- Aging * physiology MeSH
- Gastrointestinal Microbiome physiology MeSH
- Healthy Aging physiology MeSH
- Life Style MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
The prevalence of centenarians, people who lived 100 years and longer, is steadily growing in the last decades. This exceptional longevity is based on multifaceted processes influenced by a combination of intrinsic and extrinsic factors such as sex, (epi-)genetic factors, gut microbiota, cellular metabolism, exposure to oxidative stress, immune status, cardiovascular risk factors, environmental factors, and lifestyle behavior. Epidemiologically, the incidence rate of cardiovascular diseases is reduced in healthy centenarians along with late onset of age-related diseases compared with the general aged population. Understanding the mechanisms that affect vascular ageing in centenarians and the underlying factors could offer valuable insights for developing strategies to improve overall healthy life span in the elderly. This review discusses these key factors influencing vascular ageing and how their modulation could foster healthy longevity.
CIBER de Diabetes y Enfermedades Metabólicas Asociadas Instituto de Salud Carlos 3 Madrid Spain
Clinical Pharmacology Unit AP HP Hôpital Européen Georges Pompidou Paris France
Department for Biomedical Research University for Continuing Education Krems Krems Austria
Department of Biophysics School of Medicine Yeditepe University Istanbul Türkiye
Department of Internal Medicine Erasmus University Rotterdam Rotterdam Netherlands
Department of Internal Medicine University of Košice Košice Slovakia
Department of Medical Biology School of Medicine Yeditepe University Istanbul Türkiye
Department of Medical Genetics 3rd Faculty of Medicine Charles University Prague Czechia
Department of Sports Sciences at Serres Aristotle University of Thessaloniki Thessaloniki Greece
Endocrinology Diabetes and Nutrition Group Institut de Recerca SANT PAU Barcelona Spain
Institut d'Investigació Biomèdica de Girona Girona Spain
Institute of Life and Earth Sciences Heriot Watt University Edinburgh UK
Laboratory of Physiopharmacology University of Antwerp Antwerp Belgium
Menzies Institute for Medical Research University of Tasmania Hobart Australia
School of Kinesiology University of Michigan Ann Arbor MI USA
School of Nursing Psychotherapy and Community Health Dublin City University Dublin Ireland
School of Sport and Health Sciences Cardiff Metropolitan University Cardiff UK
Université Paris Cité INSERM Paris Cardiovascular Research Center PARCC Paris France
References provided by Crossref.org
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