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Oscillometry-defined small airways dysfunction as a treatable trait in asthma

M. Cottini, C. Lombardi, P. Comberiati, A. Berti, F. Menzella, RJ. Dandurand, Z. Diamant, R. Chan

. 2025 ; 134 (2) : 151-158. [pub] 20241115

Language English Country United States

Document type Journal Article, Review

Persistent link   https://www.medvik.cz/link/bmc25010100

The small airways, also referred to as the lung's silent zone, are closely associated with poor symptom control and more frequent asthma exacerbations. The oscillometry technique superimposes sound or airwaves onto normal tidal breathing and provides information on resistance and reactance, that is, obstacles to airflow occurring inside and outside of the bronchi. More recently, a management paradigm based on so-called "treatable traits" has been proposed to personalize and improve asthma care for individuals by proactively identifying and targeting modifiable pulmonary, extrapulmonary, and behavioral traits affecting asthma control. In this review article, we evaluate the literature on small airways dysfunction as a potential treatable trait in persistent asthma. In particular, we discuss whole- and intrabreath oscillometry and the impact of extrafine inhaled corticosteroids and systemic biologics on the peripheral airways.

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$a Lombardi, Carlo $u Departmental Unit of Allergology, Immunology and Pulmonary Diseases, Fondazione Poliambulanza, Brescia, Italy
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$a Comberiati, Pasquale $u Section of Paediatrics, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
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$a Berti, Alvise $u Department of Cellular, Computational and Integrative Biology (CIBIO), Center for Medical Sciences (CISMed), Italy Santa Chiara Hospital, Azienda Provinciale per i Servizi Sanitari (APSS), University of Trento, Trento, Italy
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$a Menzella, Francesco $u Pulmonology Unit, S. Valentino Hospital, Montebelluna, Marca Trevigiana, Italy
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$a Dandurand, Ronald J $u Faculty of Medicine and Health Sciences, McGill University, Montreal, Canada; Oscillometry Unit and Centre for Innovative Medicine of the McGill University Health Centre and Research Institute, Meakins-Christie Labs, Montreal Chest Institute, Montreal, Canada; Lakeshore General Hospital, Pointe-Claire, Canada; Ste-Anne Hospital, Ste-Anne-de-Bellevue, Canada
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$a Diamant, Zuzana $u Department of Clinical Pharmacy & Pharmacology, University Medical Centre Groningen, Groningen, The Netherlands; Department of Microbiology Immunology & Transplantation Ku Leuven, Leuven, Belgium; Department of Respiratory Medicine, First Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czech Republic
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$a Chan, Rory $u University of Dundee School of Medicine, Dundee, United Kingdom. Electronic address: rchan@dundee.ac.uk
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