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European consensus-based interdisciplinary guideline for melanoma. Part 1: Diagnostics - Update 2024
C. Garbe, T. Amaral, K. Peris, A. Hauschild, P. Arenberger, N. Basset-Seguin, L. Bastholt, V. Bataille, L. Brochez, V. Del Marmol, B. Dréno, AMM. Eggermont, MC. Fargnoli, AM. Forsea, C. Höller, R. Kaufmann, N. Kelleners-Smeets, A. Lallas, C....
Language English Country England, Great Britain
Document type Journal Article, Practice Guideline
- MeSH
- Dermoscopy methods standards MeSH
- Consensus * MeSH
- Humans MeSH
- Melanoma * diagnosis therapy pathology MeSH
- Skin Neoplasms * diagnosis therapy pathology MeSH
- Neoplasm Staging MeSH
- Systematic Reviews as Topic MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Practice Guideline MeSH
- Geographicals
- Europe MeSH
This guideline was developed in close collaboration with multidisciplinary experts from the European Association of Dermato-Oncology (EADO), the European Dermatology Forum (EDF) and the European Organization for Research and Treatment of Cancer (EORTC). Recommendations for the diagnosis and treatment of melanoma were developed on the basis of systematic literature research and consensus conferences. Cutaneous melanoma (CM) is the most dangerous form of skin tumor and accounts for 90 % of skin cancer mortality. The diagnosis of melanoma can be made clinically and must always be confirmed by dermoscopy. If melanoma is suspected, a histopathological examination is always required. Sequential digital dermoscopy and whole-body photography can be used in high-risk patients to improve the detection of early-stage melanoma. If available, confocal reflectance microscopy can also improve the clinical diagnosis in special cases. Melanoma is classified according to the 8th version of the American Joint Committee on Cancer classification. For thin melanomas up to a tumor thickness of 0.8 mm, no further diagnostic imaging is required. From stage IB, lymph node sonography is recommended, but no further imaging examinations. From stage IIB/C, whole-body examinations with computed tomography or positron emission tomography CT in combination with magnetic resonance imaging of the brain are recommended. From stage IIB/C and higher, a mutation test is recommended, especially for the BRAF V600 mutation. It is important to perform a structured follow-up to detect relapses and secondary primary melanomas as early as possible. A stage-based follow-up regimen is proposed, which in the experience of the guideline group covers the optimal requirements, although further studies may be considered. This guideline is valid until the end of 2026.
1st Department of Dermatology Aristotle University Thessaloniki Greece
Center for Dermatooncology Department of Dermatology Eberhard Karls University Tuebingen Germany
Department of Dermatology Erasme Hospital Université Libre de Bruxelles Brussels Belgium
Department of Dermatology Ghent University Hospital Ghent Belgium
Department of Dermatology Maastricht University Medical Center Maastricht the Netherlands
Department of Dermatology Medical University of Vienna Austria
Department of Dermatology University Hospital Schleswig Holstein Campus Kiel Kiel Germany
Department of Dermatovenereology 3rd Faculty of Medicine Charles University Prague Czech Republic
Department of Oncology Odense University Hospital Denmark
Dermatology Clinic Maggiore Hospital University of Trieste Trieste Italy
Dermatology Unit University of Modena and Reggio Emilia Modena Italy
Medical and Surgical Dermatology Service Hospital Universitario Virgen Macarena Sevilla Spain
Melanoma Unit Department of Dermatology Hospital Clinic IDIBAPS Barcelona Spain
Mount Vernon Cancer Centre Northwood United Kingdom
San Gallicano Dermatological Institute IRCCS Rome Italy
Skin Cancer Center Department of Dermatology Ruhr University Bochum 44791 Bochum Germany
The University of Manchester Oxford Rd Manchester M13 9PL UK
Université Paris Cite AP HP department of Dermatology INSERM U 976 Hôpital Saint Louis Paris France
University Medical Center Utrecht and Princess Maxima Center Utrecht the Netherlands
University of Perugia Unit of Medical Oncology Santa Maria della Misericordia Hospital Perugia Italy
References provided by Crossref.org
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