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A novel strain of Leishmania braziliensis harbors not a toti- but a bunyavirus

AY. Kostygov, D. Grybchuk, S. Heeren, ES. Gerasimov, D. Klocek, A. Reddy, J. Sádlová, L. Pacáková, A. Kohl, F. Stejskal, P. Volf, JC. Dujardin, V. Yurchenko

. 2024 ; 18 (12) : e0012767. [pub] 20241227

Language English Country United States

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc25010553

Leishmania is a genus of the family Trypanosomatidae that unites obligatory parasitic flagellates causing a variety of vector-borne diseases collectively called leishmaniasis. The symptoms range from relatively innocuous skin lesions to complete failures of visceral organs. The disease is exacerbated if a parasite harbors Leishmania RNA viruses (LRVs) of the family Pseudototiviridae. Screening a novel isolate of L. braziliensis, we revealed that it possesses not a toti-, but a bunyavirus of the family Leishbuviridae. To the best of our knowledge, this is a very first discovery of a bunyavirus infecting a representative of the Leishmania subgenus Viannia. We suggest that these viruses may serve as potential factors of virulence in American leishmaniasis and encourage researchers to test leishmanial strains for the presence of not only LRVs, but also other RNA viruses.

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$a Leishmania is a genus of the family Trypanosomatidae that unites obligatory parasitic flagellates causing a variety of vector-borne diseases collectively called leishmaniasis. The symptoms range from relatively innocuous skin lesions to complete failures of visceral organs. The disease is exacerbated if a parasite harbors Leishmania RNA viruses (LRVs) of the family Pseudototiviridae. Screening a novel isolate of L. braziliensis, we revealed that it possesses not a toti-, but a bunyavirus of the family Leishbuviridae. To the best of our knowledge, this is a very first discovery of a bunyavirus infecting a representative of the Leishmania subgenus Viannia. We suggest that these viruses may serve as potential factors of virulence in American leishmaniasis and encourage researchers to test leishmanial strains for the presence of not only LRVs, but also other RNA viruses.
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$a Grybchuk, Danyil $u Life Science Research Centre, Faculty of Science, University of Ostrava, Ostrava, Czechia $u Central European Institute of Technology, Masaryk University, Brno, Czechia
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$a Heeren, Senne $u Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium $u Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium $u Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium
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$a Gerasimov, Evgeny S $u Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia
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$a Klocek, Donnamae $u Life Science Research Centre, Faculty of Science, University of Ostrava, Ostrava, Czechia
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$a Reddy, Aditya $u Life Science Research Centre, Faculty of Science, University of Ostrava, Ostrava, Czechia
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$a Sádlová, Jovana $u Department of Parasitology, Faculty of Science, Charles University, Prague, Czechia
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$a Pacáková, Lenka $u Department of Parasitology, Faculty of Science, Charles University, Prague, Czechia
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$a Kohl, Alain $u Centre for Neglected Tropical Diseases, Departments of Tropical Disease Biology and Vector Biology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom
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$a Stejskal, František $u Department of Infectious Diseases, 2nd Faculty of Medicine and Clinics of Infectious, Parasitic, and Tropical Diseases, Bulovka University Hospital, Charles University, Prague, Czechia $u Department of Infectious Diseases, Regional Hospital Liberec, Liberec, Czechia
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$a Volf, Petr $u Department of Parasitology, Faculty of Science, Charles University, Prague, Czechia
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$a Dujardin, Jean-Claude $u Department of Biomedical Sciences, Institute of Tropical Medicine, Antwerp, Belgium
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$a Yurchenko, Vyacheslav $u Life Science Research Centre, Faculty of Science, University of Ostrava, Ostrava, Czechia $1 https://orcid.org/0000000347653263 $7 xx0234303
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