Leishmania is a genus of the family Trypanosomatidae that unites obligatory parasitic flagellates causing a variety of vector-borne diseases collectively called leishmaniasis. The symptoms range from relatively innocuous skin lesions to complete failures of visceral organs. The disease is exacerbated if a parasite harbors Leishmania RNA viruses (LRVs) of the family Pseudototiviridae. Screening a novel isolate of L. braziliensis, we revealed that it possesses not a toti-, but a bunyavirus of the family Leishbuviridae. To the best of our knowledge, this is a very first discovery of a bunyavirus infecting a representative of the Leishmania subgenus Viannia. We suggest that these viruses may serve as potential factors of virulence in American leishmaniasis and encourage researchers to test leishmanial strains for the presence of not only LRVs, but also other RNA viruses.
- MeSH
- Bunyaviridae klasifikace genetika izolace a purifikace MeSH
- fylogeneze MeSH
- Leishmania braziliensis * genetika izolace a purifikace MeSH
- lidé MeSH
- Orthobunyavirus genetika klasifikace izolace a purifikace fyziologie MeSH
- RNA-viry genetika klasifikace izolace a purifikace MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
A novel dsRNA virus was identified in the mycorrhizal fungus Thelephora terrestris (Ehrh.) and sequenced. This virus, named Thelephora terrestris virus 1 (TtV1), contains two reading frames in different frames but with the possibility that ORF2 could be translated as a fusion polyprotein after ribosomal -1 frameshifting. Picornavirus 2A-like motif, nudix hydrolase, phytoreovirus S7, and RdRp domains were found in a unique arrangement on the polyprotein. A new genus named Phlegivirus and containing TtV1, PgLV1, RfV1 and LeV is therefore proposed. Twenty species of oribatid mites were identified in soil material in the vicinity of T. terrestris. TtV1 was detected in large amounts in Steganacarus (Tropacarus) carinatus (C.L. Koch, 1841) and in much smaller amounts in Nothrus silvestris (Nicolet). This is the first description of mycovirus presence in oribatid mites.
- MeSH
- Basidiomycota virologie MeSH
- Bunyaviridae klasifikace genetika izolace a purifikace MeSH
- fylogeneze MeSH
- molekulární sekvence - údaje MeSH
- mykorhiza klasifikace genetika izolace a purifikace MeSH
- mykoviry klasifikace genetika izolace a purifikace MeSH
- roztoči mikrobiologie MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
The number of mosquito-borne viruses ('moboviruses') occurring in Europe since the twentieth century now stands at ten; they belong to three families-Togaviridae (Sindbis, Chikungunya), Flaviviridae (West Nile, Usutu, Dengue), and Bunyaviridae (Batai, Tahyna, Snowshoe hare, Inkoo, Lednice). Several of them play a definite role in human or animal pathology (Sindbis, Chikungunya, Dengue, West Nile, Tahyna). Mobovirus outbreaks are strictly determined by the presence and/or import of particular competent vectors of the disease. Ecological variables affect moboviruses considerably; the main factors are population density of mosquito vectors and their vertebrate hosts, intense summer precipitations or floods, summer temperatures and drought, and presence of appropriate habitats, e.g., wetlands, small water pools, or intravillan sewage systems. A surveillance for moboviruses and the diseases they cause in Europe is recommendable, because the cases may often pass unnoticed or misdiagnosed not only in free-living vertebrates but also in domestic animals and even in humans.
- MeSH
- Bunyaviridae izolace a purifikace MeSH
- Culicidae virologie MeSH
- epidemický výskyt choroby MeSH
- financování organizované MeSH
- Flaviviridae izolace a purifikace MeSH
- hospodářská zvířata MeSH
- hustota populace MeSH
- infekce přenášené vektorem MeSH
- lidé MeSH
- podnebí MeSH
- Togaviridae izolace a purifikace MeSH
- virové nemoci epidemiologie přenos veterinární MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Geografické názvy
- Evropa MeSH
