-
Je něco špatně v tomto záznamu ?
Distribution of human leukocyte antigen B27 (HLA-B27) in Slovak patients
A. Pobisova, A. Kollarova, V. Langraf, F. Strejcek, R. Babosova
Jazyk angličtina Země Česko
Typ dokumentu časopisecké články
Grantová podpora
026UKF-4/2024
KEGA - Slovakia
PubMed
40145884
DOI
10.32725/jab.2025.004
Knihovny.cz E-zdroje
- MeSH
- dítě MeSH
- dospělí MeSH
- HLA-B27 antigen * genetika MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- retrospektivní studie MeSH
- senioři MeSH
- spondylartropatie genetika epidemiologie imunologie MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Slovenská republika MeSH
BACKGROUND AND OBJECTIVES: HLA-B27 is a genetic marker associated with spondyloarthropathies, particularly ankylosing spondylitis and axial spondyloarthritis. While its prevalence varies across populations, no data exist for Slovak patients. This study aimed to determine HLA-B27 prevalence in Slovak patients with suspected spondyloarthropathies and assess differences by sex and age. METHODS: A retrospective cohort of 1,614 patients (888 females and 726 males) was analyzed for HLA-B27 status (positive/negative) using reverse hybridisation (HLA-B27 StripAssay). Statistical analyses included Pearson's Chi-square test and non-parametric Mann-Whitney U and Kruskal-Wallis tests for sex- and age-related differences. RESULTS: HLA-B27 positivity was 20.57%, with a higher proportion in males (23.28%) than females (18.36%, p = 0.0177). The less than 20 age group had the highest absolute number of positive cases (126 cases; 17.80%), while the 21-40 group had the highest relative positivity (119 cases; 29.38%). The lowest positivity was in the more than 61 age group (17 cases; 13.08%), though age distribution differences were not statistically significant (p = 0.7765). Positivity varies across diagnoses, peaking in musculoskeletal (M) and eye disorders (H), where it exceeds 29%. CONCLUSION: HLA-B27 positivity is strongly associated with rheumatologic and ophthalmologic conditions and exhibits age- and sex-related variability. These findings emphasize the diagnostic significance of HLA-B27 testing in Slovak patients, especially for early detection and management of spondyloarthropathies. Further research on HLA-B27 variability and its clinical implications is needed to optimize diagnostic strategies and patient care.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc25011859
- 003
- CZ-PrNML
- 005
- 20250528100057.0
- 007
- ta
- 008
- 250506s2025 xr d f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.32725/jab.2025.004 $2 doi
- 035 __
- $a (PubMed)40145884
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xr
- 100 1_
- $a Pôbišová, Alexandra $u Faculty Hospital Nitra, Department of Laboratory Medicine, Medical Genetics Laboratory, Nitra, Slovak Republic $7 xx0332468
- 245 10
- $a Distribution of human leukocyte antigen B27 (HLA-B27) in Slovak patients / $c A. Pobisova, A. Kollarova, V. Langraf, F. Strejcek, R. Babosova
- 520 9_
- $a BACKGROUND AND OBJECTIVES: HLA-B27 is a genetic marker associated with spondyloarthropathies, particularly ankylosing spondylitis and axial spondyloarthritis. While its prevalence varies across populations, no data exist for Slovak patients. This study aimed to determine HLA-B27 prevalence in Slovak patients with suspected spondyloarthropathies and assess differences by sex and age. METHODS: A retrospective cohort of 1,614 patients (888 females and 726 males) was analyzed for HLA-B27 status (positive/negative) using reverse hybridisation (HLA-B27 StripAssay). Statistical analyses included Pearson's Chi-square test and non-parametric Mann-Whitney U and Kruskal-Wallis tests for sex- and age-related differences. RESULTS: HLA-B27 positivity was 20.57%, with a higher proportion in males (23.28%) than females (18.36%, p = 0.0177). The less than 20 age group had the highest absolute number of positive cases (126 cases; 17.80%), while the 21-40 group had the highest relative positivity (119 cases; 29.38%). The lowest positivity was in the more than 61 age group (17 cases; 13.08%), though age distribution differences were not statistically significant (p = 0.7765). Positivity varies across diagnoses, peaking in musculoskeletal (M) and eye disorders (H), where it exceeds 29%. CONCLUSION: HLA-B27 positivity is strongly associated with rheumatologic and ophthalmologic conditions and exhibits age- and sex-related variability. These findings emphasize the diagnostic significance of HLA-B27 testing in Slovak patients, especially for early detection and management of spondyloarthropathies. Further research on HLA-B27 variability and its clinical implications is needed to optimize diagnostic strategies and patient care.
- 650 _2
- $a lidé $7 D006801
- 650 12
- $a HLA-B27 antigen $x genetika $7 D015796
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a retrospektivní studie $7 D012189
- 650 _2
- $a mladiství $7 D000293
- 650 _2
- $a mladý dospělý $7 D055815
- 650 _2
- $a spondylartropatie $x genetika $x epidemiologie $x imunologie $7 D025242
- 650 _2
- $a dítě $7 D002648
- 651 _2
- $a Slovenská republika $x epidemiologie $7 D018154
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Kollárová, Andrea $u Faculty Hospital Nitra, Department of Laboratory Medicine, Medical Genetics Laboratory, Nitra, Slovak Republic $7 _AN092131
- 700 1_
- $a Langraf, Vladimír, $d 1989- $u Constantine the Philosopher University in Nitra, Department of Zoology and Anthropology, Nitra, Slovak Republic $7 xx0332471
- 700 1_
- $a Strejček, František, $d 1974- $u Constantine the Philosopher University in Nitra, Department of Botany and Genetics, Nitra, Slovak Republic $7 xx0332473
- 700 1_
- $a Babosová, Ramona, $d 1988- $u Constantine the Philosopher University in Nitra, Department of Zoology and Anthropology, Nitra, Slovak Republic $7 xx0332472
- 773 0_
- $w def $t Journal of applied biomedicine $x 1214-0287 $g Roč. 23, č. 1 (2025), s. 36-44
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/40145884 $y Pubmed
- 910 __
- $a ABA008 $b B 2301 $c 1249 $y p $z 0
- 990 __
- $a 20250506 $b ABA008
- 991 __
- $a 20250528100055 $b ABA008
- 999 __
- $a ok $b bmc $g 2324887 $s 1248949
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2025 $b 23 $c 1 $d 36-44 $e 20250325 $i 1214-0287 $m Journal of applied biomedicine $n J Appl Biomed $x def
- GRA __
- $a 026UKF-4/2024 $p KEGA $2 Slovakia
- LZP __
- $b NLK124 $a Pubmed-20250506
