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Zhodnocení vlivu mnutí očí a genetické predispozice na vznik keratokonu v Bucaramanze (Kolumbie): Studie případů a kontrol
[Evaluating the influence of eye rubbing and genetic predisposition on keratoconus in Bucaramanga (Colombia): A case-control study]
María Laura Duarte-Bueno, Alejandro Tello, Alfonso Luis Diaz-Martínez, Sergio Escobar, Virgilio Galvis
Jazyk čeština Země Česko
PubMed
39891554
DOI
10.31348/2025/2
Meditorial
- Klíčová slova
- mnutí očí, spánková poloha, poloha při spaní,
- MeSH
- genetická predispozice k nemoci MeSH
- keratokonus * etiologie genetika MeSH
- klinická studie jako téma MeSH
- postura těla MeSH
- rizikové faktory MeSH
- spánek fyziologie MeSH
- zdravotně rizikové chování MeSH
Aim: To determine risk factors associated with keratoconus in Bucaramanga, Colombia. Material and Methods: A paired case-control study was conducted at Bucaramanga, Colombia, between November 2022 and December 2023. The controls were age- and sex-matched. Patients answered a questionnaire designed for this study regarding their family history of keratoconus, eye rubbing, atopy, sun exposure, and sleeping habits. Information from medical records was also obtained. Univariate and multivariate conditional analyses were used to test the significance of associations. Results: One hundred fifty-six patients with a diagnosis of keratoconus and 312 controls were included. Univariate analyses revealed significant differences between cases and controls in the following factors: very frequent eye rubbing (OR = 20.9, 95% CI 6.2–70.1), a positive family history of keratoconus (OR = 13.0, 95% CI 5.5–30.8), a personal history of atopy (OR = 2.2), and nocturnal eye compression (OR = 1.7, 95% CI 1.0–2.7). Multivariate analysis showed a statistical significance for eye rubbing (OR = 6.9, 95% CI 3.8–12.5), and family history of keratoconus (OR = 10.3, 95% CI 2.3–44.9). There was a significant mild interaction between both, since when the two coincided the OR increased up to 74.1 times. Conclusion: Eye rubbing and family history of keratoconus were the most important risk factors for keratoconus in our population. Although it is impossible to establish causal relationships, our results suggest that controlling eye rubbing could be a potentially useful preventive measure, particularly in individuals with a family history of keratoconus. Other factors, such as sun exposure, sleeping position, and atopy, may play a role in the pathophysiology of the disease.
Centro Oftalmológico Virgilio Galvis FOSCAL Floridablanca Colombia
Fundación Oftalmológica de Santander FOSCAL Floridablanca Colombia
Universidad Industrial de Santander UIS Bucaramanga Colombia
Evaluating the influence of eye rubbing and genetic predisposition on keratoconus in Bucaramanga (Colombia): A case-control study
Citace poskytuje Crossref.org
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