-
Je něco špatně v tomto záznamu ?
Value of biomarkers in the prediction of shunt responsivity in patients with normal pressure hydrocephalus
M. Cihlo, P. Trávníček, A. Tichá, R. Hyšpler, M. Kalousová, S. Řehák, K. Zadrobílek, L. Kukrálová, P. Póczoš, J. Pospíšil, P. Dostál, V. Dostálová
Jazyk angličtina Země Německo
Typ dokumentu časopisecké články, pozorovací studie
- MeSH
- amyloidní beta-protein mozkomíšní mok MeSH
- biologické markery * mozkomíšní mok MeSH
- lidé středního věku MeSH
- lidé MeSH
- neurofilamentové proteiny mozkomíšní mok MeSH
- normotenzní hydrocefalus * chirurgie mozkomíšní mok diagnóza MeSH
- peptidové fragmenty mozkomíšní mok MeSH
- prediktivní hodnota testů MeSH
- prospektivní studie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ventrikuloperitoneální zkrat * metody MeSH
- výsledek terapie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- pozorovací studie MeSH
Preoperative differentiation between responders and non-responders to ventriculoperitoneal (VP) shunting in the treatment of normal pressure hydrocephalus (NPH) remains a significant challenge. Identifying biomarkers in presurgical assessment represents a promising approach to reducing the need for invasive cerebrospinal fluid CSF testing. In this prospective observational study, thirty adult patients were classified into Group A (responders to VP shunting) and Group B (non-responders) based on their responsiveness to invasive CSF testing. The overall clinical condition and Idiopathic NPH (iNPH) scale were assessed at baseline. Additionally, biomarker levels were compared between the two groups. Elevated levels of Neurofilament Light Chain (NfL) and Neurofilament Heavy Chain (NfH) in CSF and a reduced level of beta-amyloid Aβ42 were observed. No significant differences in biomarker levels were found between groups. Individual biomarkers demonstrated only poor predictive value (AUC = 0.37-0.53). Clinical factors were stronger predictors (AUC = 0.642-0.669), with no improvement when combined with all examined biomarkers (AUC = 0.428-0.431). No single biomarker reliably predicted confirmed postoperative shunt responsiveness among patients who underwent VP shunt placement and demonstrated clinical improvement. Clinical factors were stronger predictors, suggesting that patient history and clinical assessment (e.g., the iNPH scale) provide more reliable diagnostic information. Notably, combining biomarkers with clinical factors did not improve predictive accuracy.
Department of Clinical Biochemistry University Hospital Hradec Kralove Hradec Kralove Czech Republic
Department of Neurosurgery University Hospital Hradec Kralove Hradec Kralove Czech Republic
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc25015381
- 003
- CZ-PrNML
- 005
- 20250731090936.0
- 007
- ta
- 008
- 250708s2025 gw f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1007/s10143-025-03581-3 $2 doi
- 035 __
- $a (PubMed)40457021
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a gw
- 100 1_
- $a Cihlo, Miroslav $u Department of Neurosurgery, Charles University, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic. cihlom@lfhk.cuni.cz $u Department of Neurosurgery, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic. cihlom@lfhk.cuni.cz
- 245 10
- $a Value of biomarkers in the prediction of shunt responsivity in patients with normal pressure hydrocephalus / $c M. Cihlo, P. Trávníček, A. Tichá, R. Hyšpler, M. Kalousová, S. Řehák, K. Zadrobílek, L. Kukrálová, P. Póczoš, J. Pospíšil, P. Dostál, V. Dostálová
- 520 9_
- $a Preoperative differentiation between responders and non-responders to ventriculoperitoneal (VP) shunting in the treatment of normal pressure hydrocephalus (NPH) remains a significant challenge. Identifying biomarkers in presurgical assessment represents a promising approach to reducing the need for invasive cerebrospinal fluid CSF testing. In this prospective observational study, thirty adult patients were classified into Group A (responders to VP shunting) and Group B (non-responders) based on their responsiveness to invasive CSF testing. The overall clinical condition and Idiopathic NPH (iNPH) scale were assessed at baseline. Additionally, biomarker levels were compared between the two groups. Elevated levels of Neurofilament Light Chain (NfL) and Neurofilament Heavy Chain (NfH) in CSF and a reduced level of beta-amyloid Aβ42 were observed. No significant differences in biomarker levels were found between groups. Individual biomarkers demonstrated only poor predictive value (AUC = 0.37-0.53). Clinical factors were stronger predictors (AUC = 0.642-0.669), with no improvement when combined with all examined biomarkers (AUC = 0.428-0.431). No single biomarker reliably predicted confirmed postoperative shunt responsiveness among patients who underwent VP shunt placement and demonstrated clinical improvement. Clinical factors were stronger predictors, suggesting that patient history and clinical assessment (e.g., the iNPH scale) provide more reliable diagnostic information. Notably, combining biomarkers with clinical factors did not improve predictive accuracy.
- 650 _2
- $a lidé $7 D006801
- 650 12
- $a normotenzní hydrocefalus $x chirurgie $x mozkomíšní mok $x diagnóza $7 D006850
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 12
- $a biologické markery $x mozkomíšní mok $7 D015415
- 650 _2
- $a senioři $7 D000368
- 650 12
- $a ventrikuloperitoneální zkrat $x metody $7 D017287
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a prospektivní studie $7 D011446
- 650 _2
- $a neurofilamentové proteiny $x mozkomíšní mok $7 D016900
- 650 _2
- $a amyloidní beta-protein $x mozkomíšní mok $7 D016229
- 650 _2
- $a senioři nad 80 let $7 D000369
- 650 _2
- $a výsledek terapie $7 D016896
- 650 _2
- $a prediktivní hodnota testů $7 D011237
- 650 _2
- $a peptidové fragmenty $x mozkomíšní mok $7 D010446
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a pozorovací studie $7 D064888
- 700 1_
- $a Trávníček, Pavel $u Department of Neurosurgery, Charles University, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic $u Department of Neurosurgery, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic
- 700 1_
- $a Tichá, Alena $u Department of Clinical Biochemistry, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic
- 700 1_
- $a Hyšpler, Radomír $u Department of Clinical Biochemistry, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic
- 700 1_
- $a Kalousová, Marta $u Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital in Prague, Prague, Czech Republic
- 700 1_
- $a Řehák, Svatopluk $u Department of Neurosurgery, Charles University, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic $u Department of Neurosurgery, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic
- 700 1_
- $a Zadrobílek, Karel $u Department of Neurosurgery, Charles University, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic $u Department of Neurosurgery, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic
- 700 1_
- $a Kukrálová, Lucie $u Department of Anaesthesiology and Intensive Care Medicine, Charles University, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic $u Department of Anaesthesiology and Intensive Care Medicine, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic
- 700 1_
- $a Póczoš, Pavel $u Department of Neurosurgery, Charles University, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic $u Department of Neurosurgery, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic
- 700 1_
- $a Pospíšil, Jan $u Department of Anaesthesiology and Intensive Care Medicine, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic
- 700 1_
- $a Dostál, Pavel $u Department of Anaesthesiology and Intensive Care Medicine, Charles University, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic $u Department of Anaesthesiology and Intensive Care Medicine, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic
- 700 1_
- $a Dostálová, Vlasta $u Department of Anaesthesiology and Intensive Care Medicine, Charles University, Faculty of Medicine in Hradec Kralove, Hradec Kralove, Czech Republic $u Department of Anaesthesiology and Intensive Care Medicine, University Hospital Hradec Kralove, Hradec Kralove, Czech Republic
- 773 0_
- $w MED00003513 $t Neurosurgical review $x 1437-2320 $g Roč. 48, č. 1 (2025), s. 474
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/40457021 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y - $z 0
- 990 __
- $a 20250708 $b ABA008
- 991 __
- $a 20250731090930 $b ABA008
- 999 __
- $a ok $b bmc $g 2366301 $s 1252506
- BAS __
- $a 3
- BAS __
- $a PreBMC-MEDLINE
- BMC __
- $a 2025 $b 48 $c 1 $d 474 $e 20250603 $i 1437-2320 $m Neurosurgical review $n Neurosurg Rev $x MED00003513
- LZP __
- $a Pubmed-20250708
