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Adherence to Physical Activity and Incident Mobility Disability in Older Adults With Mobility Limitations
A. Álvarez-Bustos, HJ. Coelho-Junior, R. Calvani, L. Rodriguez-Mañas, M. Tosato, M. Cesari, A. Cherubini, AJ. Cruz-Jentoft, PV. Jónsson, F. Lattanzio, M. Maggio, R. Roller-Wirnsberger, I. Rýznarová, AMWJ. Schols, CC. Sieber, AJ. Sinclair, A....
Language English Country Germany
Document type Journal Article, Multicenter Study, Randomized Controlled Trial
Grant support
IMI-JU 115621
Innovative Medicines Initiative Joint Undertaking
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PubMed
40532064
DOI
10.1002/jcsm.13870
Knihovny.cz E-resources
- MeSH
- Exercise * physiology MeSH
- Humans MeSH
- Mobility Limitation * MeSH
- Persons with Disabilities MeSH
- Sarcopenia * physiopathology therapy MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Aged, 80 and over MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Multicenter Study MeSH
- Randomized Controlled Trial MeSH
BACKGROUND: Preservation of mobility independence is a primary goal in older adults with physical frailty and sarcopenia (PF&S). Interventions based on the combination of physical activity (PA) and nutritional counselling have been indicated as strategies for the management of this condition, although their effectiveness is not confirmed in all investigations. A possible explanation for this uncertain scenario relies in the impact of the adherence to PA interventions. Hence, the present study investigated the impact of the adherence to PA sessions on the incidence of mobility disability in older adults with PF&S. METHODS: This is a secondary analysis of an evaluator blinded, randomised controlled trial, developed in 16 clinical sites across 11 European countries, from January 2016 to 31 October 2019. Participants were community-dwelling older adults (70+ years) with PF&S enrolled in the SPRINTT trial (NCT02582138). PF&S was operationalised as having a total score from 3 to 9 on the short physical performance battery (SPPB), low appendicular lean mass and ability to complete the 400-m walk test in < 15 min. Data from participants allocated to a multicomponent intervention (PA with technological support plus nutritional counselling) and a healthy ageing lifestyle education programme (control group) were analysed. Adherence to PA was assessed based on the number of weekly sessions attended. According to recommendations of the American College of Sports Medicine, adherence was categorised as below recommendations (< 2 sessions/week, BR), meeting recommendations (2-3 sessions/week, MR), and above recommendations (> 3 sessions/week, AR). The primary outcome was incident mobility disability, operationalised as incident inability to complete the 400-m walk test in < 15 min during up to 36 months of follow-up. RESULTS: Data of 1444 participants (mean age 79.3 years, 72.6% women) were analysed. In those with SPPB scores of 3-7, MR and AR groups had lower risk of mobility disability compared with controls [MR HR (95% CI): 0.57 (0.41-0.78), p = 0.001; AR HR (95% CI): 0.33 (0.23-0.46), p < 0.001] and BR groups [MR: HR (95% CI): 0.48 (0.34-0.69), p < 0.001; AR: HR (95% CI): 0.27 (0.18-0.38), p < 0.001] in a dose-dependent manner. In those with SPPB scores of 8 or 9, the BR group had a higher risk of mobility disability than controls. MR and AR groups had a lower risk of mobility disability than the BR group. CONCLUSIONS: In older adults with PF&S, adherence to PA recommendations is associated with lower incidence of mobility disability. This benefit depends on the degree of adherence as well as baseline physical performance. TRIAL REGISTRATION: ClinicalTrials.gov NCT02582138.
Center for Life Course Health Research University of Oulu Oulu Finland
CHU Limoges Department of Geriatric Medicine UR 24134 VieSante Research Unit Limoges France
Department of Cardiology and Pneumology University Göttingen Medical Center Göttingen Germany
Department of Clinical and Molecular Sciences Università Politecnica delle Marche Ancona Italy
Department of Clinical Sciences and Community Health University of Milan Milan Italy
Department of Geriatrics Hospital Universitario de Getafe Madrid Spain
Department of Internal Medicine Medical University of Graz Graz Austria
Department of Medicine and Surgery Università degli Studi di Parma Parma Italy
DROP and King's College London UK
DZHK Partner Site Lower Saxony Göttingen Germany
Faculty of Health and Social Sciences University of South Bohemia Ceske Budejovice Czech Republic
Fondazione Policlinico Universitario Agostino Gemelli IRCCS Rome Italy
Geriatria Accettazione Geriatrica e Centro di Ricerca per l'Invecchiamento IRCCS INRCA Ancona Italy
Gérontopôle Centre Hospitalier Universitaire de Toulouse Toulouse France
Helsinki University and Helsinki University Hospital Helsinki Finland
IHU HealthAge CHU University of Toulouse INSERM CERPOP Toulouse France
Instituto de Investigación IdiPaz Madrid Spain
Servicio de Geriatría Hospital Universitario Ramón y Cajal IRYCIS Madrid Spain
References provided by Crossref.org
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