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Identification of nanoparticle infiltration in human breast milk: Chemical profiles and trajectory pathways
Q. Yang, D. Chen, X. Liu, W. Li, H. Zheng, X. Cai, R. Li
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
Grantová podpora
2022YFE0124000
the National Key R&D Program of China
82473680
the National Natural Science Fundation of China
CZ.10.03.01/00/22_003/0000048
the European Union under the REFRESH - Research Excellence for Region Sustainability and High-tech Industries project
NLK
Free Medical Journals
od 1915 do Před 6 měsíci
Freely Accessible Science Journals
od 1915 do Před 6 měsíci
PubMed Central
od 1915 do Před 6 měsíci
Europe PubMed Central
od 1915 do Před 6 měsíci
Open Access Digital Library
od 1915-01-01
Open Access Digital Library
od 1915-01-15
PubMed
40354532
DOI
10.1073/pnas.2500552122
Knihovny.cz E-zdroje
- MeSH
- lidé MeSH
- mateřské mléko * chemie metabolismus MeSH
- nanočástice * chemie analýza MeSH
- velikost částic MeSH
- vztahy mezi strukturou a aktivitou MeSH
- Check Tag
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Breast milk is crucial for infant health, offering essential nutrients and immune protection. However, despite increasing exposure risks from nanoparticles (NPs), their potential infiltration into human breast milk remains poorly understood. This study provides a comprehensive chemical profile of NPs in human breast milk, analyzing their elemental composition, surface charge, hydrodynamic size, and crystallinity. NPs were detected in 42 out of 53 milk samples, with concentrations reaching up to 1.12 × 1011 particles/mL. These particles comprised nine elements, with O, Si, Fe, Cu, and Al being the most frequently detected across all samples. We establish a mechanistic axis for NP infiltration, involving penetration of the intestine/air-blood barriers, circulation in blood vessels, crossing the blood-milk barrier via transcytosis or immune cell-mediated transfer, and eventual accumulation in milk. Structure-activity relationship analysis reveals that smaller, neutral-charged NPs exhibit stronger infiltration capacity, offering potential for regulating NP behavior at biological barriers through engineering design. This study provides the chemical profiles of NPs in human breast milk and uncovers their infiltration pathways.
Citace poskytuje Crossref.org
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