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The landscape of immune monitoring in CAR-T cell therapy: A comprehensive review and survey study by the Cellular Therapy and Immunobiology Working Party of the EBMT
S. Pagliuca, F. Malard, JE. Mooyaart, M. Daskalakis, L. Gabellier, I. Yakoub-Agha, R. Ram, C. Besley, E. Forcade, V. Vucinic, LL. Corral, J. Vydra, B. von Tresckow, P. Amat, P. Amrolia, P. Vandenberghe, F. Stölzel, S. Sica, MT. Rubio, JD....
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, přehledy
- MeSH
- chimerické antigenní receptory * imunologie MeSH
- imunoterapie adoptivní * metody škodlivé účinky MeSH
- lidé MeSH
- monitorování imunologické metody MeSH
- průzkumy a dotazníky MeSH
- T-lymfocyty imunologie metabolismus MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Immune monitoring of cell therapies is a complex and evolving topic, particularly in the rapid expanding field of chimeric antigen receptor T (CAR-T) cell applications. Defining essential, recommended, and optional immune monitoring data post-CAR-T cell infusion is crucial to improve patient outcomes and inform post-treatment decisions. To address this gap, we conducted a survey-based study across centers affiliated with the European Society for Blood and Marrow Transplantation (EBMT), focusing on patients treated with European Medicines Agency (EMA)-approved CAR-T products. Building on a thorough review of the literature, we mapped the current landscape of immune monitoring practices and assessed their impact on clinical management. By defining the state of the art in the field, this work marks an initial step towards a structured harmonization process potentially able to enhance the management and outcomes of patients undergoing these immune cell therapies.
Chaim Sheba Medical Center Tel Hashomer Israel
CHU Bordeaux Hopital Haut Leveque Pessac France
CHU Montpellier UMR CNRS 5535 Montpellier France
EBMT Leiden Study Unit Leiden the Netherlands
Great Ormond Street Children's Hospital Paediatrics London United Kingdom
Hospital Clínico CIBERONC Centro de Investigación del Cáncer IBMCC Salamanca Spain
Hospital Clínico Universitario INCLIVA de Valencia Spain
Institute of Hematology and Blood Transfusion Prague Czech Republic
Medical Clinic and Policinic 1 Leipzig Germany
Oncoimmunotherapy Unit Department of Hematology Hospital Clinic Barcelona Spain
San Raffaele Scientific Institute Hematology and Bone Marrow Transplantation Unit Milan Italy
Tel Aviv Sourasky Medical Center and Faculty of Medicine Tel Aviv University Tel Aviv Israel
Universita Cattolica S Cuore Rome Italy
University Hospital Bern Bern Switzerland
University Hospital Gasthuisberg Leuven Belgium
University Hospital Schleswig Holstein Kiel University Kiel Germany
University Hospitals Bristol and Weston NHSFT Bristol United Kingdom
Citace poskytuje Crossref.org
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- $a Pagliuca, Simona $u Hematology department, Nancy University Hospital, UMR 7365, CNRS, University of Lorraine, Vandoeuvre-lès-Nancy, France. Electronic address: s.pagliuca@chru-nancy.fr
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- $a Immune monitoring of cell therapies is a complex and evolving topic, particularly in the rapid expanding field of chimeric antigen receptor T (CAR-T) cell applications. Defining essential, recommended, and optional immune monitoring data post-CAR-T cell infusion is crucial to improve patient outcomes and inform post-treatment decisions. To address this gap, we conducted a survey-based study across centers affiliated with the European Society for Blood and Marrow Transplantation (EBMT), focusing on patients treated with European Medicines Agency (EMA)-approved CAR-T products. Building on a thorough review of the literature, we mapped the current landscape of immune monitoring practices and assessed their impact on clinical management. By defining the state of the art in the field, this work marks an initial step towards a structured harmonization process potentially able to enhance the management and outcomes of patients undergoing these immune cell therapies.
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