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Report of Consensus Panel 2 from the 12th International Workshop on the management of Bing-Neel syndrome in patients with Waldenstrom's Macroglobulinemia
S. Sarosiek, AL. Becking, A. Branagan, S. Ferrero, J. Khwaja, E. Kimby, D. Roos-Weil, N. Sekiguchi, M. Trneny, S. Yi, CJ. Patterson, C. Buske, JV. Matous, SP. Treon, MC. Minnema
Language English Country United States
Document type Consensus Development Conference, Journal Article
- MeSH
- Protein Kinase Inhibitors therapeutic use MeSH
- Consensus MeSH
- Humans MeSH
- Disease Management MeSH
- Piperidines therapeutic use MeSH
- Agammaglobulinaemia Tyrosine Kinase antagonists & inhibitors MeSH
- Pyrazoles therapeutic use MeSH
- Pyrimidines therapeutic use MeSH
- Waldenstrom Macroglobulinemia * diagnosis therapy drug therapy MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Consensus Development Conference MeSH
Consensus panel 2 from the 12th International Workshop on Waldenstrom Macroglobulinemia was tasked with updating the guidelines on the diagnosis and management of patients with Bing-Neel syndrome (BNS). In this panel we have summarized the clinical symptoms that may be present with BNS, discussed the criteria required for diagnosis of BNS, made recommendations for follow-up imaging, and proposed revised guidelines for response assessment in BNS. The key recommendations from the 12th International Workshop on WM (IWWM-12) Consensus panel 2 include: (1) the establishment of zanubrutinib as a standard therapy for treatment of BNS; (2) recommendations on imaging and CSF evaluation during treatment and follow-up of BNS; and (3) revised response criteria in view of new data showing that malignant cells can persist in the CSF of many patients treated with BTK-inhibitors. New categorical response categories proposed include that for a Clinical Complete Response and Progressive Disease.
Colorado Blood Cancer Institute Sarah Cannon Research Institute Denver CO
Division of Hematology department of Medicine Karolinska Institutet Huddinge Stockholm Sweden
Hematology Department Sorbonne University Pitié Salpêtrière hospital Paris France
Hematology Division National Hospital Organization Disaster Medical Center Tokyo Japan
Institute of Experimental Cancer Research University Hospital Ulm Ulm Germany
References provided by Crossref.org
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