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Effects of high salt intake on glucose metabolism, liver function, and the microbiome in rats: influence of ACE inhibitors and angiotensin II receptor blockers
X. Zhang, MMS. Gaballa, AA. Hasan, Y. Liu, JG. Hocher, X. Chen, L. Liu, J. Li, D. Wigger, C. Reichetzeder, S. Elitok, B. Kleuser, BK. Krämer, B. Hocher
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
Grantová podpora
2022RC40
Hunan High-Level Talent Aggregation Project
Boehringer Ingelheim (Boehringer Ingelheim International GmbH)
YNXM-202304
Researsch Grant of CITIC-Xiangya
202008430176
China Scholarship Council (CSC)
Deutschland-Stipendium der Charite Universitatsmedizin Berlin
NLK
American Physiological Society
od 2024-03-01
Open Access Digital Library
od 1997-10-01
- MeSH
- antagonisté receptorů pro angiotenzin * farmakologie MeSH
- enalapril farmakologie MeSH
- glukosa * metabolismus MeSH
- inhibitory ACE * farmakologie MeSH
- játra * účinky léků metabolismus MeSH
- krevní glukóza metabolismus účinky léků MeSH
- krevní tlak účinky léků MeSH
- krysa rodu rattus MeSH
- kuchyňská sůl * škodlivé účinky MeSH
- potkani Sprague-Dawley MeSH
- střevní mikroflóra * účinky léků MeSH
- telmisartan farmakologie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
High-salt diets (HSDs) are known to impact blood pressure and cardiovascular health, but their effects on glucose metabolism, liver function, and gut microbiota remain poorly understood. This study investigates how long-term HSD affects these physiological processes and evaluates the potential therapeutic effects of ACE inhibitors (ACEIs) and angiotensin II receptor blockers (ARBs). Male Sprague-Dawley rats were fed a normal salt diet (0.3% NaCl), a moderate salt diet (2% NaCl), or a high-salt diet (8% NaCl) for 12 wk. Two subgroups in the HSD condition received telmisartan or enalapril. We assessed blood pressure, glucose homeostasis, liver inflammation, pancreatic function, and gut microbiota composition. HSD rats exhibited significantly higher blood pressure [130 ± 2 mmHg in normal diet (ND) vs. 144 ± 4 mmHg in HSD; P < 0.01], reduced fasting insulin (1.33 ± 0.14 ng/mL in ND vs. 0.60 ± 0.05 ng/mL in HSD; P < 0.01), and gut microbiota dysbiosis, with a 71% reduction in Ruminococcus species (P = 0.018). Liver inflammation, indicated by an increase in CD68+ macrophages, was also observed in the HSD group. Telmisartan treatment significantly reduced liver inflammation but did not fully restore metabolic homeostasis. HSD disrupts multiple physiological systems, including glucose metabolism and liver function, partly through gut microbiota alterations. ACEIs and ARBs provided partial protection, highlighting the need for multitargeted interventions to mitigate high-salt diet effects.NEW & NOTEWORTHY High-salt diet induces multisystem disruptions, including liver inflammation, reduced insulin levels, and gut microbiota imbalance. ACEIs and ARBs showed limited efficacy, highlighting the need for comprehensive therapeutic approaches.
2nd Medical Faculty Charles University Prague Prague Czech Republic
Academy of Scientific Research and Technology Cairo Egypt
Department of Nephrology and Endocrinology Klinikum Ernst von Bergmann Potsdam Germany
Faculty of Veterinary Medicine Benha University Toukh Egypt
Guangzhou Linghang Digital Technology Co Ltd Guangzhou People's Republic of China
Institute for Clinical Research and Systems Medicine Health and Medical University Potsdam Germany
Institute of Medical Diagnostics Berlin Germany
Institute of Pharmacy Freie Universität Berlin Berlin Germany
Medical Faculty of Charité Universitätsmedizin Berlin Berlin Germany
Citace poskytuje Crossref.org
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