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Physician's global assessment of disease activity in juvenile idiopathic arthritis: consensus-based recommendations from an international task force
V. Rypdal, HI. Brunner, BM. Feldman, N. Ruperto, A. Aggarwal, ST. Angeles-Han, M. Backström, E. Balay-Dustrude, C. Bracaglia, F. De Benedetti, P. Doležalová, M. Garrone, J. Guzman, DB. Horton, RM. Laxer, DJ. Lovell, T. Løvli, S. Magni-Manzoni, F....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, konsensuální prohlášení
- MeSH
- dítě MeSH
- juvenilní artritida * diagnóza MeSH
- konsensus MeSH
- lidé MeSH
- poradní výbory MeSH
- revmatologie normy MeSH
- stupeň závažnosti nemoci * MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- konsensuální prohlášení MeSH
OBJECTIVES: To develop consensus-based recommendations for physician's global assessment of disease activity (PhGA) scoring and to standardise definitions of disease activity. METHODS: An international task force of 34 members was assembled, and recommendations were developed in 3 phases: (1) 2 preliminary surveys of paediatric rheumatologists and a literature review; (2) 14 videoconference meetings, informed by multicriteria decision analysis and formal anonymous voting; and (3) a 2-day in-person consensus conference using structured nominal group technique discussions and formal voting. The threshold for achieving consensus was ≥78% of voting task force members. Agreement with the final statements was rated using a numerical rating scale from 0, strongly disagree, to 10, strongly agree. RESULTS: Eighteen points to consider were agreed upon. All statements achieved consensus (≥78%), with a level of agreement ≥9.2. Points included the definition of disease activity in juvenile idiopathic arthritis (JIA), factors to assess in nonsystemic JIA and systemic JIA, consideration of available imaging and laboratory tests, the role of extra-articular manifestations, the evaluation of treatment, and the timing of PhGA scoring. CONCLUSIONS: The task force developed consensus-based recommendations when scoring the PhGA in nonsystemic and systemic JIA. These recommendations will lead to more reliable scoring of disease activity in patients with JIA.
1st Faculty of Medicine Charles University Prague Prague Czech Republic
Department of Biostatistics and Epidemiology Rutgers School of Public Health Piscataway NJ USA
Department of Children and Adolescents Oulu University Hospital
Department of Clinical Medicine UIT the Arctic University of Norway Tromsø Norway
Department of Pediatric Rheumatology Seattle Children's Hospital and Research Center Seattle WA USA
Department of Pediatrics Division of Rheumatology University of Washington Seattle WA USA
Department of Pediatrics The Wellbeing Services County of Ostrobothnia Vaasa Finland
Department of Pediatrics University Hospital of North Norway Tromsø Norway
Division of Pediatric Rheumatology University of British Columbia Vancouver BC Canada
Division of Rheumatology IRCCS Ospedale Pediatrico Bambino Gesù Roma Rome Italy
IRCCS Fondazione San Gerardo dei Tintori Clinica Pediatrica Fondazione PRINTO Monza Italy
IRCCS Istituto Giannina Gaslini Genoa Italy
Medical Research Center Oulu University Hospital and University of Oulu Oulu Finland
Research Unit of Clinical Medicine University of Oulu
Research Unit of Clinical Medicine University of Oulu Oulu Finland
São Paulo State University Botucatu São Paulo Brazil
Systemic JIA Foundation Cincinnati OH USA
The Hospital for Sick Children University of Toronto Toronto ON Canada
Università degli Studi di Genova Genova Italy
Citace poskytuje Crossref.org
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- $a Rypdal, Veronika $u Department of Pediatrics, University Hospital of North Norway, Tromsø, Norway; Department of Clinical Medicine, UIT the Arctic University of Norway, Tromsø, Norway. Electronic address: veronika.rypdal@unn.no
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- $a OBJECTIVES: To develop consensus-based recommendations for physician's global assessment of disease activity (PhGA) scoring and to standardise definitions of disease activity. METHODS: An international task force of 34 members was assembled, and recommendations were developed in 3 phases: (1) 2 preliminary surveys of paediatric rheumatologists and a literature review; (2) 14 videoconference meetings, informed by multicriteria decision analysis and formal anonymous voting; and (3) a 2-day in-person consensus conference using structured nominal group technique discussions and formal voting. The threshold for achieving consensus was ≥78% of voting task force members. Agreement with the final statements was rated using a numerical rating scale from 0, strongly disagree, to 10, strongly agree. RESULTS: Eighteen points to consider were agreed upon. All statements achieved consensus (≥78%), with a level of agreement ≥9.2. Points included the definition of disease activity in juvenile idiopathic arthritis (JIA), factors to assess in nonsystemic JIA and systemic JIA, consideration of available imaging and laboratory tests, the role of extra-articular manifestations, the evaluation of treatment, and the timing of PhGA scoring. CONCLUSIONS: The task force developed consensus-based recommendations when scoring the PhGA in nonsystemic and systemic JIA. These recommendations will lead to more reliable scoring of disease activity in patients with JIA.
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