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Dissection of Neurochemical Pathways Across Complexity and Scale
A. Abbondanza, N. Kim, RAS. Lima-Filho, A. Amin, RG. Anversa, FB. Almeida, PL. Cardozo, G. Carello-Collar, EV. Carsana, RO. Folarin, S. Guerreiro, OK. Ijomone, SK. Lawal, I. Matias, SI. Mbagwu, SA. Niño, BF. Olabiyi, SY. Olatunji, TA. Olasehinde,...
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, přehledy
PubMed
40692178
DOI
10.1111/jnc.70160
Knihovny.cz E-zdroje
- MeSH
- lidé MeSH
- mozek * metabolismus MeSH
- neurochemie * metody trendy MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
The field of Neurochemistry spent decades trying to understand how the brain works, from nano to macroscale and across diverse species. Technological advancements over the years allowed researchers to better visualize and understand the cellular processes underpinning central nervous system (CNS) function. This review provides an overview of how novel models, and tools have allowed Neurochemistry researchers to investigate new and exciting research questions. We discuss the merits and demerits of different in vivo models (e.g., Caenorhabditis elegans, Drosophila melanogaster, Ratus norvegicus, and Mus musculus) as well as in vitro models (e.g., primary cells, induced pluripotent stem cells, and immortalized cells) to study Neurochemical events. We also discuss how these models can be paired with cutting-edge genetic manipulation (e.g., CRISPR-Cas9 and engineered viral vectors) and imaging techniques, such as super-resolution microscopy and new biosensors, to study cellular processes of the CNS. These technological advancements provide new insight into Neurochemical events in physiological and pathological contexts, paving the way for the development of new treatments (e.g., cell and gene therapies or small molecules) that aim to treat neurological disorders by reverting the CNS to its homeostatic state.
Centre for Discovery Brain Sciences University of Edinburgh Edinburgh UK
CNRS Inserm Institut de Biologie Paris Seine Sorbonne Université Paris France
Department of Anatomy Faculty of Basic Medical Sciences Nnamdi Azikiwe University Anambra Nigeria
Department of Anatomy University of Medical Sciences Ondo Nigeria
Department of Biology Faculty of Sciences Universidad de Chile Santiago Chile
Department of Clinical Chemistry Faculty of Medical Technology Mahidol University Bangkok Thailand
Department of Medical Biotechnology and Translational Medicine University of Milan Milan Italy
Discipline of Microbiology School of Life Sciences University of Kwazulu Natal Durban South Africa
Division of BioMedical Sciences University of Global Health Equity Butaro Rwanda
Food Chemistry Faculty of Mathematics and Natural Science University of Wuppertal Wuppertal Germany
Geroscience Center for Brain Health and Metabolism Santiago Chile
ICVS 3B's PT Government Associate Laboratory Braga Portugal
Institute of Biomedical Sciences Federal University of Rio de Janeiro Rio de Janeiro Brazil
Institute of Chemistry University of Tartu Tartu Estonia
Life and Health Sciences Research Institute School of Medicine University of Minho Braga Portugal
Medical Faculty Institute of Molecular Psychiatry University of Bonn Bonn Germany
Muir Maxwell Epilepsy Centre University of Edinburgh Edinburgh UK
School of Nursing Faculty of Health Sciences University of Botswana Garborone Botswana
Simons Initiative for the Developing Brain University of Edinburgh Edinburgh UK
Citace poskytuje Crossref.org
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