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Transcriptomics insight into occupational exposure to engineered nanoparticles

Z. Simova, M. Sima, D. Pelclova, P. Klusackova, V. Zdimal, J. Schwarz, L. Maskova, J. Klema, S. Dvorackova, P. Rossner, A. Rossnerova

. 2025 ; 20 (14) : 1713-1727. [pub] 20250703

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc25022490

AIM: To investigate the effect of acute (daily) inhalation of nanoparticles (NPs) on the transcriptomic profile of male nanocomposite research workers with a history of long-term exposure (years). MATERIALS & METHODS: Whole genome mRNA and miRNA expression changes were analyzed from blood samples collected before and after machining or welding. Exposure in the work environment was assessed using stationary and personal monitoring. RESULTS: Following PM0.1 exposure, a significant decrease in the expression of DDIT4 and FKBP5, genes involved in the stress response, was detected in exposed workers. In the Machining group, the DDIT4 expression correlated with the exposure dose. Increased levels of miR30-d-5p and miR-3613-5p (both involved in carcinogenesis) in welders were associated with the NP exposure dose, highlighting their potential suitability as inhalation exposure markers. CONCLUSION: The results from this pilot transcriptomic analysis (mRNA and miRNA) indicate that exposure to NPs contributes to immune system deregulation and alters the pathways related to cancer. Therefore, the use of protective equipment, as well as obtaining more data by additional research, is highly recommended.

Citace poskytuje Crossref.org

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$a Sima, Michal $u Department of Toxicology and Molecular Epidemiology, Institute of Experimental Medicine CAS, Prague, Czech Republic
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$a Pelclova, Daniela $u Department of Occupational Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic
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$a Klusackova, Pavlina $u Department of Occupational Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic
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$a Zdimal, Vladimir $u Department of Aerosol Chemistry and Physics, Institute of Chemical Process Fundamentals CAS, Prague, Czech Republic
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$a Schwarz, Jaroslav $u Department of Aerosol Chemistry and Physics, Institute of Chemical Process Fundamentals CAS, Prague, Czech Republic
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$a Maskova, Ludmila $u Department of Aerosol Chemistry and Physics, Institute of Chemical Process Fundamentals CAS, Prague, Czech Republic
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$a Klema, Jiri $u Department of Computer Science, Czech Technical University in Prague, Prague, Czech Republic
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$a Dvorackova, Stepanka $u Department of Machining & Assembly, Department of Engineering Technology, Department of Material Science, Faculty of Mechanical Engineering, Technical University in Liberec, Liberec, Czech Republic
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$a Rossner, Pavel $u Department of Toxicology and Molecular Epidemiology, Institute of Experimental Medicine CAS, Prague, Czech Republic
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