Effect of papaverine on the longitudinal and circular smooth muscle of the guinea-pig caecum
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články
PubMed
135990
Knihovny.cz E-zdroje
- MeSH
- cékum * MeSH
- extracelulární prostor metabolismus MeSH
- hladké svalstvo účinky léků MeSH
- morčata MeSH
- papaverin farmakologie MeSH
- svalová kontrakce účinky léků MeSH
- vápník metabolismus MeSH
- zvířata MeSH
- Check Tag
- morčata MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- papaverin MeSH
- vápník MeSH
Electrical and mechanical activity of smooth muscle of the guinea-pig caecum was recorded by means of the sucrose-gap technique. The responses of longitudinal and circular smooth muscle to acetycholine were differently affected by changes of extracellular calcium concentration (0.8, 2.5 and 7.5 mM). The contractions of both preparations were depressed at high Ca++ concentrations, whereas at low Ca++ concentrations only contractions of the circular smooth muscle were augmented. The stimulatory effect of acetylcholine was decreased by papaverine in both preparations at all three concentrations of Ca++. This inhibition was the greater the lower the concentration of extracellular Ca++ and this process was more pronounced in the circular muscle. The ability of papaverine to counteract the effect of lowered concentrations of extracellular Ca++ on membrane excitability may well explain its inhibitory effect upon intestinal smooth muscle.