Na-G-penicillin penetration into rat cerebral cortex and formation of an epileptic focus
Jazyk angličtina Země Česko Médium print
Typ dokumentu časopisecké články
PubMed
149321
Knihovny.cz E-zdroje
- MeSH
- krysa rodu Rattus MeSH
- mozková kůra metabolismus MeSH
- penicilin G metabolismus MeSH
- záchvaty chemicky indukované metabolismus MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- penicilin G MeSH
Fluorescein isothiocyanate-labelled Na-G-penicillin was applied to the intact dura of 11 rats and the cortical layers were determined to which this epileptogenic substance must penetrate for electrophysiologically demonstrable focal activity to be induced. In 10 animals labelled penicillin was demonstrated in cortical layers I--III and in one animal in layers I and II. This concurs with the results obtained in 12 other animals in which activity was recorded from three depths of the cerebral cortex with semimicroelectrodes.
Epilepsy Research in the Institute of Physiology of the Czech Academy of Sciences in Prague
