Toxic and reactogenic properties of pertussis bacteria (experimental and clinical studies)
Language English Country Czech Republic Media print
Document type Clinical Trial, Comparative Study, Journal Article
PubMed
171306
Knihovny.cz E-resources
- MeSH
- Toxins, Biological biosynthesis toxicity MeSH
- Bordetella pertussis metabolism pathogenicity MeSH
- Species Specificity MeSH
- Drug Evaluation MeSH
- Clinical Trials as Topic MeSH
- Infant MeSH
- Lethal Dose 50 MeSH
- Humans MeSH
- Lymphocytes drug effects MeSH
- Mice MeSH
- Adrenal Glands pathology MeSH
- Pertussis Vaccine toxicity MeSH
- Leukocyte Count MeSH
- Drug Evaluation, Preclinical MeSH
- Body Weight drug effects MeSH
- Vaccination adverse effects MeSH
- Animals MeSH
- Check Tag
- Infant MeSH
- Humans MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Clinical Trial MeSH
- Comparative Study MeSH
- Names of Substances
- Toxins, Biological MeSH
- Pertussis Vaccine MeSH
The results of the study revealed correlation between the reactogenicity of pertussis vaccines in epidemiological observations and the toxic properties of pertussis bacteria in experiment. Quantitative and qualitative differences were found between the toxic factors in pertussis bacteria depending on their type-specific serological activity. Serotype 1.0.3 microbes exhibit more pronounced toxicity which accounts for the greater reactogenicity of vaccines prepared from this serotype as compared with the preparation produced from the serotype 1.2.3. The obtained results suggest the necessity of considering the greater toxicity of the serotype 1.0.3 in the preparation of pertussis vaccines.
