Variability in the production of nogalamycin by Streptomyces nogalater var. nogalater was followed in untreated and mutagenized populations of the standard strain NRRL 3035 and its spontaneous variant K-18 using the method of agar blocks with subsequent tests under submerged conditions. In both strains the most active variants were obtained by natural selection without mutagenic treatment; in this way productivity increased by 108% after two selection steps. Treatment with UV-radiation did not yield variants with a highly increased activity. Gamma-radiation extended the variability but, at the same, substantially increased the number of non-producing and low-producing isolates. Relatively high yields of (+)-variants were obtained after treatment with nitrous acid but their activity did not reach that observed in the most active spontaneous variants.

See more in PubMed

Folia Microbiol (Praha). 1974;19(2):133-8 PubMed

Folia Microbiol (Praha). 1977;22(5):321-8 PubMed

Folia Microbiol (Praha). 1971;16(3):218-24 PubMed

Folia Microbiol (Praha). 1971;16(3):197-204 PubMed

Tetrahedron Lett. 1968 Feb;6:663-8 PubMed

Antibiotiki (Mosc). 1958 Mar-Apr;3(2):18-21 PubMed

Antimicrob Agents Chemother (Bethesda). 1965;5:836-44 PubMed

Antibiotiki. 1966 Oct;11(10):872-7 PubMed

Tr Latv Padomju Soc Repub Zinat Akad Mikrobiol Inst. 1961;10:159-63 PubMed

Ann N Y Acad Sci. 1954 Oct 29;60(1):136-51 PubMed

J Appl Bacteriol. 1974 Dec;37(4):515-23 PubMed

Folia Microbiol (Praha). 1977;22(2):139-59 PubMed

Antibiotiki. 1974 Jun;19(6):509-14 PubMed

Folia Microbiol (Praha). 1977;22(4):275-85 PubMed

Antibiotiki. 1972 Jan;17(1):8-11 PubMed

Folia Microbiol (Praha). 1976;21(4):285-93 PubMed

Antibiotiki. 1974 Apr;19(4):315-9 PubMed

Compounds isolated at the Department of Biogenesis of Natural Substances, Institute of Microbiology, Czechoslovak Academy of Sciences, in 1954-1983

Mutants of Streptomyces coeruleorubidus impaired in the biosynthesis of daunomycinone glycosides and related metabolites

Strain improvement in Streptomyces galilaeus, a producer of anthracycline antibiotics galirubins