Studies on the production of daunomycinone-derived glycosides and related metabolites in Streptomyces coeruleorubidus and Streptomyces peucetius
Jazyk angličtina Země Spojené státy americké Médium print
Typ dokumentu časopisecké články
PubMed
892669
DOI
10.1007/bf02877657
Knihovny.cz E-zdroje
- MeSH
- chromatografie na tenké vrstvě MeSH
- daunomycin analogy a deriváty biosyntéza izolace a purifikace MeSH
- fermentace MeSH
- glykosidy biosyntéza MeSH
- kultivační média MeSH
- ponoření MeSH
- Streptomyces metabolismus MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- daunomycin MeSH
- glykosidy MeSH
- kultivační média MeSH
Strains of Streptomyces coeruleorubidus ISP 5145, JA 10092 and 39-146, differing mutually in antibiotic activity, were found to produce identical spectrum of metabolites (at least nine antibiotically active glycosides, 13-dihydrodaunomycinone, epsilon-rhodomycinone and a larger number of unidentified compounds); only trace quantities of daunomycin and daunomycinone could be detected. A fraction of glycosides with a higher RF (0.4-0.7), isolated from strain 39-146, could be transformed to daunomycin by mild hydrolysis and to daunomycinone by total hydrolysis. Streptomyces peucetius IMI 101 335 differed from Streptomyces coeruleorubidus in an increased production of epsilon-rhodomycinone and a lower content of glycosides; the zone of daunomycin was most pronounced among the glycoside spots. Streptomyces coeruleorubidus 39-146 exhibited the highest activity in a medium containing 3.5% soluble starch, 3.0% soybean meal, 0.3% NaCl and 0.3% CaCo3; glucose was a more useful carbon source for the remaining strains. The activity of Streptomyces coeruleoribidus was inhibited by 1-propanol, Na-propionate, 5,5-diethylbarbiturate and bacitracin. Ferrous sulphate stimulated the production of glycosides only in strain JA 10092, decreasing simultaneously the production of aglycones.
Zobrazit více v PubMed
Antibiotiki. 1970 May;15(5):403-6 PubMed
Antibiotiki. 1966 Sep;11(9):763-7 PubMed
Ann N Y Acad Sci. 1974 May 10;235(0):601-12 PubMed
Arzneimittelforschung. 1975 Mar;25(3):368-74 PubMed
Biotechnol Bioeng. 1969 Nov;11(6):1101-10 PubMed
Folia Microbiol (Praha). 1977;22(3):182-8 PubMed
Antibiotiki. 1966 Oct;11(10):872-7 PubMed
Folia Microbiol (Praha). 1976;21(1):43-9 PubMed
Antibiotiki. 1976 Apr;21(4):299-301 PubMed
Folia Microbiol (Praha). 1977;22(2):139-59 PubMed
Propionate and the production of monensins in Streptomyces cinnamonensis
Biotransformations of anthracyclinones in Streptomyces coeruleorubidus and Streptomyces galilaeus
7-Deoxy-13-dihydrodaunomycinone in cultures of Streptomyces coeruleorubidus
Improved yields of daunomycinone glycosides in developmental mutants of Streptomyces coeruleorubidus
Spontaneous and induced variability in Streptomyces nogalater producing nogalamycin
Strain improvement in Streptomyces galilaeus, a producer of anthracycline antibiotics galirubins