Studies on the production of daunomycinone-derived glycosides and related metabolites in Streptomyces coeruleorubidus and Streptomyces peucetius

. 1977 ; 22 (4) : 275-85.

Jazyk angličtina Země Spojené státy americké Médium print

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/pmid00892669

Strains of Streptomyces coeruleorubidus ISP 5145, JA 10092 and 39-146, differing mutually in antibiotic activity, were found to produce identical spectrum of metabolites (at least nine antibiotically active glycosides, 13-dihydrodaunomycinone, epsilon-rhodomycinone and a larger number of unidentified compounds); only trace quantities of daunomycin and daunomycinone could be detected. A fraction of glycosides with a higher RF (0.4-0.7), isolated from strain 39-146, could be transformed to daunomycin by mild hydrolysis and to daunomycinone by total hydrolysis. Streptomyces peucetius IMI 101 335 differed from Streptomyces coeruleorubidus in an increased production of epsilon-rhodomycinone and a lower content of glycosides; the zone of daunomycin was most pronounced among the glycoside spots. Streptomyces coeruleorubidus 39-146 exhibited the highest activity in a medium containing 3.5% soluble starch, 3.0% soybean meal, 0.3% NaCl and 0.3% CaCo3; glucose was a more useful carbon source for the remaining strains. The activity of Streptomyces coeruleoribidus was inhibited by 1-propanol, Na-propionate, 5,5-diethylbarbiturate and bacitracin. Ferrous sulphate stimulated the production of glycosides only in strain JA 10092, decreasing simultaneously the production of aglycones.

Zobrazit více v PubMed

Antibiotiki. 1970 May;15(5):403-6 PubMed

Antibiotiki. 1966 Sep;11(9):763-7 PubMed

Ann N Y Acad Sci. 1974 May 10;235(0):601-12 PubMed

Arzneimittelforschung. 1975 Mar;25(3):368-74 PubMed

Biotechnol Bioeng. 1969 Nov;11(6):1101-10 PubMed

Folia Microbiol (Praha). 1977;22(3):182-8 PubMed

Antibiotiki. 1966 Oct;11(10):872-7 PubMed

Folia Microbiol (Praha). 1976;21(1):43-9 PubMed

Antibiotiki. 1976 Apr;21(4):299-301 PubMed

Folia Microbiol (Praha). 1977;22(2):139-59 PubMed

Nejnovějších 20 citací...

Zobrazit více v
Medvik | PubMed

Streptomycetes producing daunomycin and related compounds: do we know enough about them after 25 years?

. 1989 ; 34 (4) : 324-49.

Propionate and the production of monensins in Streptomyces cinnamonensis

. 1988 ; 33 (6) : 440-6.

Compounds isolated at the Department of Biogenesis of Natural Substances, Institute of Microbiology, Czechoslovak Academy of Sciences, in 1954-1983

. 1984 ; 29 (1) : 51-89.

Intra- and interspecific cosynthetic activity of mutants of Streptomyces coeruleorubidus and Streptomyces galilaeus impaired in the biosynthesis of anthracyclines

. 1979 ; 24 (2) : 128-35.

Effect of aeration efficiency and carbon source on the production of anthracyclines in Streptomyces galilaeus

. 1979 ; 24 (4) : 301-7.

Biotransformations of anthracyclinones in Streptomyces coeruleorubidus and Streptomyces galilaeus

. 1979 ; 24 (2) : 117-27.

7-Deoxy-13-dihydrodaunomycinone in cultures of Streptomyces coeruleorubidus

. 1978 ; 23 (3) : 246-8.

Development mutants of Streptomyces coeruleorubidus, a producer of anthracyclines: isolation and preliminary characterization

. 1978 ; 23 (3) : 177-82.

Mutants of Streptomyces coeruleorubidus impaired in the biosynthesis of daunomycinone glycosides and related metabolites

. 1978 ; 23 (4) : 255-60.

Improved yields of daunomycinone glycosides in developmental mutants of Streptomyces coeruleorubidus

. 1978 ; 23 (4) : 249-54.

Spontaneous and induced variability in Streptomyces nogalater producing nogalamycin

. 1977 ; 22 (4) : 286-94.

Strain improvement in Streptomyces galilaeus, a producer of anthracycline antibiotics galirubins

. 1977 ; 22 (5) : 321-8.

Najít záznam

Citační ukazatele

Nahrávání dat ...

    Možnosti archivace